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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell–and patient-derived tumor organoids
L Huang, A Holtzinger, I Jagan, M BeGora, I Lohse, N Ngai, C Nostro, ...
Nature medicine 21 (11), 1364-1371, 2015
5272015
Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia
DT Marie-Egyptienne, I Lohse, RP Hill
Cancer letters 341 (1), 63-72, 2013
2262013
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies
H Yang, S Kurtenbach, Y Guo, I Lohse, MA Durante, J Li, Z Li, H Al-Ali, ...
Blood, The Journal of the American Society of Hematology 131 (3), 328-341, 2018
1152018
Effect of high dose per pulse flattening filter-free beams on cancer cell survival
I Lohse, S Lang, J Hrbacek, S Scheidegger, S Bodis, NS Macedo, J Feng, ...
Radiotherapy and Oncology 101 (1), 226-232, 2011
1002011
Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle
MJ Ernsting, B Hoang, I Lohse, E Undzys, P Cao, T Do, B Gill, M Pintilie, ...
Journal of controlled release 206, 122-130, 2015
992015
Quantitative proteomic analysis of serum exosomes from patients with locally advanced pancreatic cancer undergoing chemoradiotherapy
M An, I Lohse, Z Tan, J Zhu, J Wu, H Kurapati, MA Morgan, TS Lawrence, ...
Journal of proteome research 16 (4), 1763-1772, 2017
852017
BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts
I Lohse, A Borgida, P Cao, M Cheung, M Pintilie, T Bianco, S Holter, ...
British journal of cancer 113 (3), 425-432, 2015
682015
Assessment of hypoxia in the stroma of patient-derived pancreatic tumor xenografts
I Lohse, C Lourenco, E Ibrahimov, M Pintilie, MS Tsao, DW Hedley
Cancers 6 (1), 459-471, 2014
602014
mRNA-to-protein translation in hypoxia
NT Chee, I Lohse, SP Brothers
Molecular cancer 18 (1), 1-13, 2019
522019
Unraveling biophysical interactions of radiation pneumonitis in non-small-cell lung cancer via Bayesian network analysis
Y Luo, I El Naqa, DL McShan, D Ray, I Lohse, MM Matuszak, D Owen, ...
Radiotherapy and Oncology 123 (1), 85-92, 2017
502017
Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
I Lohse, J Rasowski, P Cao, M Pintilie, T Do, MS Tsao, RP Hill, ...
Oncotarget 7 (23), 33571, 2016
462016
Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study
RT Swords, D Azzam, H Al-Ali, I Lohse, CH Volmar, JM Watts, A Perez, ...
Leukemia research 64, 34-41, 2018
432018
Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts
I Lohse, J Mason, PC Mary, M Pintilie, M Bray, DW Hedley
Oncotarget 8 (2), 3064, 2017
402017
Fbxw7 deletion accelerates KrasG12D-Driven pancreatic tumorigenesis via Yap accumulation
Q Zhang, Y Zhang, JD Parsels, I Lohse, TS Lawrence, MP di Magliano, ...
Neoplasia 18 (11), 666-673, 2016
322016
Effects of combined treatment with ionizing radiation and the PARP inhibitor olaparib in BRCA mutant and wild type patient-derived pancreatic cancer xenografts
I Lohse, R Kumareswaran, P Cao, B Pitcher, S Gallinger, RG Bristow, ...
PLoS One 11 (12), e0167272, 2016
262016
Pathogenesis and treatment of pancreatic cancer related pain
I Lohse, SP Brothers
Anticancer research 40 (4), 1789-1796, 2020
252020
The CPT1C 5′ UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK
I Lohse, P Reilly, K Zaugg
PLoS one 6 (9), e21486, 2011
242011
Precision medicine in the treatment stratification of AML patients: challenges and progress
I Lohse, K Statz-Geary, SP Brothers, C Wahlestedt
Oncotarget 9 (102), 37790, 2018
192018
Naturally occurring compounds as pancreatic cancer therapeutics
I Lohse, E Wildermuth, SP Brothers
Oncotarget 9 (83), 35448, 2018
172018
BET bromodomain inhibitors which permit treg function enable a combinatorial strategy to suppress GVHD in pre-clinical allogeneic HSCT
SN Copsel, CO Lightbourn, H Barreras, I Lohse, D Wolf, CS Bader, ...
Frontiers in immunology 9, 3104, 2019
152019
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