Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells PM Tedeschi, EK Markert, M Gounder, H Lin, D Dvorzhinski, SC Dolfi, ... Cell death & disease 4 (10), e877-e877, 2013 | 276 | 2013 |
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates SC Dolfi, LLY Chan, J Qiu, PM Tedeschi, JR Bertino, KM Hirshfield, ... Cancer & metabolism 1, 1-13, 2013 | 183 | 2013 |
Overexpression of the mitochondrial folate and glycine–serine pathway: a new determinant of methotrexate selectivity in tumors A Vazquez, PM Tedeschi, JR Bertino Cancer research 73 (2), 478-482, 2013 | 88 | 2013 |
Mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) overexpression is associated with tumor cell proliferation and is a novel target for drug development PM Tedeschi, A Vazquez, JE Kerrigan, JR Bertino Molecular Cancer Research 13 (10), 1361-1366, 2015 | 75 | 2015 |
NAD+ Kinase as a Therapeutic Target in Cancer PM Tedeschi, N Bansal, JE Kerrigan, EE Abali, KW Scotto, JR Bertino Clinical cancer research 22 (21), 5189-5195, 2016 | 70 | 2016 |
Functional annotation of rare gene aberration drivers of pancreatic cancer YH Tsang, T Dogruluk, PM Tedeschi, J Wardwell-Ozgo, H Lu, M Espitia, ... Nature communications 7 (1), 10500, 2016 | 63 | 2016 |
In cancer, all roads lead to NADPH GM Rather, AA Pramono, Z Szekely, JR Bertino, PM Tedeschi Pharmacology & therapeutics 226, 107864, 2021 | 41 | 2021 |
Enhanced degradation of dihydrofolate reductase through inhibition of NAD kinase by nicotinamide analogs YC Hsieh, P Tedeschi, RAB Lawal, D Banerjee, K Scotto, JE Kerrigan, ... Molecular pharmacology 83 (2), 339-353, 2013 | 32 | 2013 |
Suppression of cytosolic NADPH pool by thionicotinamide increases oxidative stress and synergizes with chemotherapy PM Tedeschi, HX Lin, M Gounder, JE Kerrigan, EE Abali, K Scotto, ... Molecular pharmacology 88 (4), 720-727, 2015 | 28 | 2015 |
Quantification of folate metabolism using transient metabolic flux analysis PM Tedeschi, N Johnson-Farley, H Lin, LM Shelton, T Ooga, G Mackay, ... Cancer & metabolism 3, 1-14, 2015 | 22 | 2015 |
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts PM Tedeschi, YK Kathari, IN Farooqi, JR Bertino Cancer chemotherapy and pharmacology 74, 1029-1032, 2014 | 17 | 2014 |
MTHFD2-a new twist? PM Tedeschi, KW Scotto, J Kerrigan, JR Bertino Oncotarget 7 (7), 7368, 2016 | 8 | 2016 |
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis 2013; 4: e877 PM Tedeschi | 6 | 2013 |
The castrate resistant PC-3 cell line with neuroendocrine features is enriched in tumor initiating cells and is resistant to enzalutamide and abiraterone but sensitive to … N Bansal, L Wu, NJ Farley, P Tedeschi, JR Bertino Cancer Research 75 (15_Supplement), 4208-4208, 2015 | 2 | 2015 |
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination PM Tedeschi, YK Kathari, N Johnson-Farley, JR Bertino Cancer chemotherapy and pharmacology 75, 1247-1252, 2015 | 2 | 2015 |
Cell proliferation and tissue remodeling are major determinants of cancer metabolism and the response to drugs targeting metabolism E Markert, P Tedeschi, S Dolphi, K Hirshfield, J Bertino, Z Oltvai, ... Cancer & Metabolism 2, 1-1, 2014 | 1 | 2014 |
Abstract PR06: Functional prioritization of rare gene aberration drivers of cancer K Scott, YH Tsang, T Dogruluk, P Tedeschi, J Bertino, G Mills Cancer Research 75 (22_Supplement_1), PR06-PR06, 2015 | | 2015 |
Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination PM Tedeschi, YK Kathari, I Farooqi, JR Bertino Cancer Research 74 (19_Supplement), 843-843, 2014 | | 2014 |
Abstract C151: Contribution of serine, folate, and glycine metabolism to the ATP, NADPH, and purine requirements of cancer cells. PM Tedeschi, EK Markert, M Gounder, HX Lin, SC Dolfi, LLY Chan, J Qiu, ... Molecular Cancer Therapeutics 12 (11_Supplement), C151-C151, 2013 | | 2013 |
Abstract A266: Leucovorin rescue of high dose pralatrexate in mesothelioma xenografts. PM Tedeschi, I Farooqi, Y Kathari, JR Bertino Molecular Cancer Therapeutics 12 (11_Supplement), A266-A266, 2013 | | 2013 |