Involvement of microRNA in AU-rich element-mediated mRNA instability Q Jing, S Huang, S Guth, T Zarubin, A Motoyama, J Chen, F Di Padova, ... Cell 120 (5), 623-634, 2005 | 1105 | 2005 |
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38δ Y Jiang, H Gram, M Zhao, L New, J Gu, L Feng, F Di Padova, RJ Ulevitch, ... Journal of Biological Chemistry 272 (48), 30122-30128, 1997 | 751 | 1997 |
MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α B Ge, H Gram, F Di Padova, B Huang, L New, RJ Ulevitch, Y Luo, J Han Science 295 (5558), 1291-1294, 2002 | 696 | 2002 |
In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. H Gram, LA Marconi, CF Barbas 3rd, TA Collet, RA Lerner, AS Kang Proceedings of the National Academy of Sciences 89 (8), 3576-3580, 1992 | 590 | 1992 |
Regulation of the MEF2 family of transcription factors by p38 M Zhao, L New, VV Kravchenko, Y Kato, H Gram, F Di Padova, EN Olson, ... Molecular and cellular biology 19 (1), 21-30, 1999 | 584 | 1999 |
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1 MI Koenders, E Lubberts, B Oppers-Walgreen, L van den Bersselaar, ... The American journal of pathology 167 (1), 141-149, 2005 | 374 | 2005 |
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2 U Knauf, C Tschopp, H Gram Molecular and cellular biology 21 (16), 5500-5511, 2001 | 309 | 2001 |
Eukaryotic expression systems: a comparison S Geisse, H Gram, B Kleuser, HP Kocher Protein expression and purification 8 (3), 271-282, 1996 | 289 | 1996 |
A randomized controlled trial with an anti‐CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis JJ Haringman, DM Gerlag, TJM Smeets, D Baeten, F Van den Bosch, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2006 | 287 | 2006 |
Generation of Rabbit Monoclonal Antibody Fragments from a Combinatorial Phage Display Library and Their Production in the Yeast Pichia pastoris R Ridder, R Schmitz, F Legay, H Gram Bio/technology 13 (3), 255-260, 1995 | 286 | 1995 |
The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis R Alten, H Gram, LA Joosten, WB Berg, J Sieper, S Wassenberg, ... Arthritis research & therapy 10, 1-9, 2008 | 259 | 2008 |
Neutralization of interleukin‐1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice F Clausen, A Hånell, M Björk, L Hillered, AK Mir, H Gram, N Marklund European Journal of Neuroscience 30 (3), 385-396, 2009 | 226 | 2009 |
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice D Gomez, RA Baylis, BG Durgin, AAC Newman, GF Alencar, S Mahan, ... Nature medicine 24 (9), 1418-1429, 2018 | 219 | 2018 |
Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody A Chakraborty, S Tannenbaum, C Rordorf, PJ Lowe, D Floch, H Gram, ... Clinical pharmacokinetics 51, e1-e18, 2012 | 197 | 2012 |
Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display R Schmitz, G Baumann, H Gram Journal of molecular biology 260 (5), 664-677, 1996 | 194 | 1996 |
Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity O Osborn, SE Brownell, M Sanchez-Alavez, D Salomon, H Gram, T Bartfai Cytokine 44 (1), 141-148, 2008 | 187 | 2008 |
Neutralization of interleukin‐1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice F Clausen, A Hånell, C Israelsson, J Hedin, T Ebendal, AK Mir, H Gram, ... European Journal of Neuroscience 34 (1), 110-123, 2011 | 179 | 2011 |
Regulation of TNF expression by multiple mitogen-activated protein kinase pathways W Zhu, JS Downey, J Gu, F Di Padova, H Gram, J Han The Journal of Immunology 164 (12), 6349-6358, 2000 | 165 | 2000 |
Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1 M Brauchle, D Glück, F Di Padova, J Han, H Gram Experimental cell research 258 (1), 135-144, 2000 | 115 | 2000 |
IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor-and toll-like receptor 7-mediated signaling and gene expression M Koziczak-Holbro, C Joyce, A Glück, B Kinzel, M Müller, C Tschopp, ... Journal of biological chemistry 282 (18), 13552-13560, 2007 | 110 | 2007 |