|Aspects of the general biology of adenosine A2A signaling|
BB Fredholm, Y Chern, R Franco, M Sitkovsky
Progress in neurobiology 83 (5), 263-276, 2007
|A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease|
HY Hsiao, YC Chen, HM Chen, PH Tu, Y Chern
Human molecular genetics 22 (9), 1826-1842, 2013
|CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model|
SY Chou, YC Lee, HM Chen, MC Chiang, HL Lai, HH Chang, YC Wu, ...
Journal of neurochemistry 93 (2), 310-320, 2005
|Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease|
TC Ju, HM Chen, JT Lin, CP Chang, WC Chang, JJ Kang, CP Sun, ...
Journal of Cell Biology 194 (2), 209-227, 2011
|Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response|
HL Lai, TH Yang, RO Messing, YH Ching, SC Lin, Y Chern
Journal of Biological Chemistry 272 (8), 4970-4977, 1997
|Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism|
WC Shen, HY Li, GC Chen, Y Chern, P Tu
Autophagy 11 (4), 685-700, 2015
|Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models|
YT Lin, Y Chern, CKJ Shen, HL Wen, YC Chang, H Li, TH Cheng, ...
PloS one 6 (8), e22924, 2011
|Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease|
JJ Siew, HM Chen, HY Chen, HL Chen, CM Chen, BW Soong, YR Wu, ...
Nature communications 10 (1), 1-18, 2019
|Activation of protein kinase A and atypical protein kinase C by A2A adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells|
NK Huang, YW Lin, CL Huang, RO Messing, Y Chern
Journal of Biological Chemistry 276 (17), 13838-13846, 2001
|Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage …|
HC Cheng, HM Shih, Y Chern
Journal of Biological Chemistry 277 (37), 33930-33942, 2002
|Adenosine receptor neurobiology: overview|
JF Chen, C Lee, Y Chern
International review of neurobiology 119, 1-49, 2014
|Regulation of adenylyl cyclase in the central nervous system|
Cellular signalling 12 (4), 195-204, 2000
|Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells.|
Y Chern, HL Lai, JC Fong, Y Liang
Molecular pharmacology 44 (5), 950-958, 1993
|Dysregulation of C/EBPα by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease|
MC Chiang, HM Chen, YH Lee, HH Chang, YC Wu, BW Soong, CM Chen, ...
Human molecular genetics 16 (5), 483-498, 2007
|Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease|
HY Hsiao, FL Chiu, CM Chen, YR Wu, HM Chen, YC Chen, HC Kuo, ...
Human molecular genetics 23 (16), 4328-4344, 2014
|Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes|
SY Chou, JY Weng, HL Lai, F Liao, SH Sun, PH Tu, DW Dickson, Y Chern
Journal of Neuroscience 28 (13), 3277-3290, 2008
|Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma|
MC Chiang, CM Chen, MR Lee, HW Chen, HM Chen, YS Wu, CH Hung, ...
Human molecular genetics 19 (20), 4043-4058, 2010
|PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease|
MC Chiang, Y Chern, RN Huang
Neurobiology of disease 45 (1), 322-328, 2012
|Spt4 is selectively required for transcription of extended trinucleotide repeats|
CR Liu, CR Chang, Y Chern, TH Wang, WC Hsieh, WC Shen, CY Chang, ...
Cell 148 (4), 690-701, 2012
|Neurovascular abnormalities in humans and mice with Huntington's disease|
CY Lin, YH Hsu, MH Lin, TH Yang, HM Chen, YC Chen, HY Hsiao, ...
Experimental neurology 250, 20-30, 2013