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An enolase inhibitor for the targeted treatment of ENO1-deleted cancers YH Lin, N Satani, N Hammoudi, VC Yan, Y Barekatain, S Khadka, ... Nature metabolism 2 (12), 1413-1426, 2020 | 47 | 2020 |
Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools A Bianchi-Smiraglia, A Bagati, EE Fink, S Moparthy, JA Wawrzyniak, ... Oncogene 36 (1), 84-96, 2017 | 40 | 2017 |
Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity A Bianchi-Smiraglia, JA Wawrzyniak, A Bagati, EK Marvin, J Ackroyd, ... Cell Death & Differentiation 22 (11), 1858-1864, 2015 | 37 | 2015 |
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine Y Barekatain, JJ Ackroyd, VC Yan, S Khadka, L Wang, KC Chen, ... Nature communications 12 (1), 4228, 2021 | 26 | 2021 |
Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo ST Gammon, F Pisaneschi, ML Bandi, MG Smith, Y Sun, Y Rao, F Muller, ... Cells 8 (12), 1487, 2019 | 22 | 2019 |
Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity B Ladd, JJ Ackroyd, JK Hicks, CE Canman, SA Flanagan, DS Shewach DNA repair 12 (12), 1114-1121, 2013 | 18 | 2013 |
Eradication of ENO1-deleted Glioblastoma through Collateral Lethality YH Lin, N Satani, N Hammoudi, JJ Ackroyd, S Khadka, VC Yan, ... BioRxiv, 331538, 2018 | 16 | 2018 |
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma S Khadka, K Arthur, Y Barekatain, E Behr, M Washington, J Ackroyd, ... Cancer & Metabolism 9 (1), 27, 2021 | 12 | 2021 |
Pharmacokinetics of orally administered GS-441524 in dogs VC Yan, CD Pham, MJ Yan, AJ Yan, S Khadka, K Arthur, JJ Ackroyd, ... bioRxiv, 2021 | 10 | 2021 |
Drug metabolism and homologous recombination repair in radiosensitization with gemcitabine MM Im, SA Flanagan, JJ Ackroyd, DS Shewach Radiation research 183 (1), 114-123, 2015 | 10 | 2015 |
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Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 … TL Pulliam, D Awad, JJ Han, MM Murray, JJ Ackroyd, P Goli, JS Oakhill, ... Cells 11 (12), 1890, 2022 | 7 | 2022 |
Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers VC Yan, CD Pham, ES Ballato, KL Yang, K Arthur, S Khadka, ... Journal of Medicinal Chemistry 65 (20), 13813-13832, 2022 | 3 | 2022 |
Robust detection of oncometabolic aberrations by 1H–13C heteronuclear single quantum correlation in intact biological specimens Y Barekatain, VC Yan, K Arthur, JJ Ackroyd, S Khadka, J De Groot, ... Communications Biology 3 (1), 328, 2020 | 3 | 2020 |
Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas Y Barekatain, VC Yan, JJ Ackroyd, AH Poral, T Tran, DK Georgiou, ... bioRxiv, 769885, 2019 | 1 | 2019 |
Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity D Awad, PHA Cao, TL Pulliam, M Spradlin, E Subramani, TV Tellman, ... Cancer Research 84 (5), 703-724, 2024 | | 2024 |
Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism S Khadka, YH Lin, J Ackroyd, YA Chen, Y Sheng, W Qian, S Guo, Y Chen, ... bioRxiv, 2023 | | 2023 |