aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation R Francis, G McGrath, J Zhang, DA Ruddy, M Sym, J Apfeld, M Nicoll, ... Developmental cell 3 (1), 85-97, 2002 | 1179 | 2002 |
Radial glial identity is promoted by Notch1 signaling in the murine forebrain N Gaiano, JS Nye, G Fishell Neuron 26 (2), 395-404, 2000 | 902 | 2000 |
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells S Hitoshi, T Alexson, V Tropepe, D Donoviel, AJ Elia, JS Nye, RA Conlon, ... Genes & development 16 (7), 846-858, 2002 | 847 | 2002 |
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. R Kopan, EH Schroeter, H Weintraub, JS Nye Proceedings of the National Academy of Sciences 93 (4), 1683-1688, 1996 | 629 | 1996 |
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD R Kopan, JS Nye, H Weintraub Development 120 (9), 2385-2396, 1994 | 628 | 1994 |
Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor. A Verma, JS Nye, SH Snyder Proceedings of the National Academy of Sciences 84 (8), 2256-2260, 1987 | 382 | 1987 |
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells JS Nye, R Kopan, R Axel Development 120 (9), 2421-2430, 1994 | 374 | 1994 |
Glycogen synthase kinase-3β modulates notch signaling and stability DR Foltz, MC Santiago, BE Berechid, JS Nye Current Biology 12 (12), 1006-1011, 2002 | 342 | 2002 |
Safety and efficacy of galantamine in subjects with mild cognitive impairment B Winblad, S Gauthier, L Scinto, H Feldman, GK Wilcock, L Truyen, ... Neurology 70 (22), 2024-2035, 2008 | 325 | 2008 |
Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives J Pitha, T Irie, PB Sklar, JS Nye Life sciences 43 (6), 493-502, 1988 | 304 | 1988 |
Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors CB Chambers, Y Peng, H Nguyen, N Gaiano, G Fishell, JS Nye Development 128 (5), 689-702, 2001 | 244 | 2001 |
Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1 JL Franklin, BE Berechid, FB Cutting, A Presente, CB Chambers, DR Foltz, ... Current Biology 9 (24), 1448-1457, 1999 | 192 | 1999 |
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice R Mancuso, G Fryatt, M Cleal, J Obst, E Pipi, J Monzón-Sandoval, E Ribe, ... Brain 142 (10), 3243-3264, 2019 | 169 | 2019 |
Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality Y Zhu, C Qi, Y Jia, JS Nye, MS Rao, JK Reddy Journal of Biological Chemistry 275 (20), 14779-14782, 2000 | 163 | 2000 |
Human cortical neuronal cell line: establishment from a patient with unilateral megalencephaly GV Ronnett, LD Hester, JS Nye, K Connors, SH Snyder Science 248 (4955), 603-605, 1990 | 163 | 1990 |
Developmental signalling: vertebrate ligands for Notch JS Nye, R Kopan Current Biology 5 (9), 966-969, 1995 | 155 | 1995 |
Inflammatory biomarkers in Alzheimer's disease plasma AR Morgan, S Touchard, C Leckey, C O'Hagan, AJ Nevado-Holgado, ... Alzheimer's & dementia 15 (6), 776-787, 2019 | 140 | 2019 |
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis BTD Tobe, AM Crain, AM Winquist, B Calabrese, H Makihara, W Zhao, ... Proceedings of the National Academy of Sciences 114 (22), E4462-E4471, 2017 | 136 | 2017 |
Mutant lambda phage repressor with a specific defect in its positive control function. L Guarente, JS Nye, A Hochschild, M Ptashne Proceedings of the National Academy of Sciences 79 (7), 2236-2239, 1982 | 132 | 1982 |
Innovative solutions to novel drug development in mental health TR Insel, V Voon, JS Nye, VJ Brown, BM Altevogt, ET Bullmore, ... Neuroscience & Biobehavioral Reviews 37 (10), 2438-2444, 2013 | 123 | 2013 |