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Shehab Ismail
Shehab Ismail
Dirección de correo verificada de kuleuven.be - Página principal
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Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling
G Zimmermann, B Papke, S Ismail, N Vartak, A Chandra, M Hoffmann, ...
Nature 497 (7451), 638-642, 2013
6862013
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins
A Chandra, HE Grecco, V Pisupati, D Perera, L Cassidy, F Skoulidis, ...
Nature cell biology 14 (2), 148-158, 2012
3922012
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
SA Ismail, YX Chen, A Rusinova, A Chandra, M Bierbaum, L Gremer, ...
Nature chemical biology 7 (12), 942-949, 2011
2952011
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium
SE Reid, EJ Kay, LJ Neilson, AT Henze, J Serneels, EJ McGhee, ...
The EMBO journal 36 (16), 2373-2389, 2017
1912017
Identification of pyrazolopyridazinones as PDEδ inhibitors
B Papke, S Murarka, HA Vogel, P Martín-Gago, M Kovacevic, DC Truxius, ...
Nature communications 7 (1), 11360, 2016
1652016
Structural basis for Arl3‐specific release of myristoylated ciliary cargo from UNC119
SA Ismail, YX Chen, M Miertzschke, IR Vetter, C Koerner, A Wittinghofer
The EMBO journal 31 (20), 4085-4094, 2012
1222012
Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
FG Kugeratski, SJ Atkinson, LJ Neilson, S Lilla, JRP Knight, J Serneels, ...
Science signaling 12 (567), eaan8247, 2019
1002019
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
JR Hernandez-Fernaud, E Ruengeler, A Casazza, LJ Neilson, E Pulleine, ...
Nature communications 8 (1), 14206, 2017
1002017
Post‐proteomic identification of a novel phage‐encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes
RK Aziz, SA Ismail, HW Park, M Kotb
Molecular microbiology 54 (1), 184-197, 2004
1002004
A PDE6δ‐KRas inhibitor chemotype with up to seven H‐bonds and picomolar affinity that prevents efficient inhibitor release by Arl2
P Martín‐Gago, EK Fansa, CH Klein, S Murarka, P Janning, M Schürmann, ...
Angewandte Chemie 129 (9), 2463-2468, 2017
932017
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism
SA Ismail, IR Vetter, B Sot, A Wittinghofer
Cell 141 (5), 812-821, 2010
832010
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site
G Zimmermann, C Schultz-Fademrecht, P Küchler, S Murarka, S Ismail, ...
Journal of medicinal chemistry 57 (12), 5435-5448, 2014
812014
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
EK Fansa, SK Kösling, E Zent, A Wittinghofer, S Ismail
Nature communications 7 (1), 11366, 2016
792016
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex
S Veltel, A Kravchenko, S Ismail, A Wittinghofer
Febs Letters 582 (17), 2501-2507, 2008
792008
ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition
S Alkanderi, E Molinari, R Shaheen, Y Elmaghloob, LA Stephen, ...
The American Journal of Human Genetics 103 (4), 612-620, 2018
762018
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo
D Wätzlich, I Vetter, K Gotthardt, M Miertzschke, YX Chen, A Wittinghofer, ...
EMBO reports 14 (5), 465-472, 2013
732013
Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
L Fort, JM Batista, PA Thomason, HJ Spence, JA Whitelaw, L Tweedy, ...
Nature cell biology 20 (10), 1159-1171, 2018
702018
Predicted incorporation of non‐native substrates by a polyketide synthase yields bioactive natural product derivatives
K Bravo‐Rodriguez, AF Ismail‐Ali, S Klopries, S Kushnir, S Ismail, ...
ChemBioChem 15 (13), 1991-1997, 2014
582014
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness
N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, SWG Tait, ...
Journal of Cell Biology 220 (12), e202006049, 2021
552021
Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase
SA Ismail, HW Park
Acta Crystallographica Section D: Biological Crystallography 61 (11), 1508-1513, 2005
552005
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