| Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA A Ryo, F Suizu, Y Yoshida, K Perrem, YC Liou, G Wulf, R Rottapel, ... Molecular cell 12 (6), 1413-1426, 2003 | 838 | 2003 |
| Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling F Pages, M Ragueneau, R Rottapel, A Truneh, J Nunes, J Imbert, D Olive Nature 369 (6478), 327-329, 1994 | 505 | 1994 |
| The MAGUK family protein CARD11 is essential for lymphocyte activation H Hara, T Wada, C Bakal, I Kozieradzki, S Suzuki, N Suzuki, M Nghiem, ... Immunity 18 (6), 763-775, 2003 | 405 | 2003 |
| Essential gene profiles in breast, pancreatic, and ovarian cancer cells R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... Cancer discovery 2 (2), 172-189, 2012 | 375 | 2012 |
| W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. AD Reith, R Rottapel, E Giddens, C Brady, L Forrester, A Bernstein Genes & development 4 (3), 390-400, 1990 | 372 | 1990 |
| The c-kit receptor ligand functions as a mast cell chemoattractant CJ Meininger, H Yano, R Rottapel, A Bernstein, KM Zsebo, BR Zetter | 368 | 1992 |
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat Molecular systems biology 10 (7), 733, 2014 | 364 | 2014 |
| The Steel/W Transduction Pathway: Kit Autophosphorylation and Its Association with a Unique Subset of Cytoplasmic Signaling Proteins Is Induced by the Steel … R Rottapel, M Reedijk, DE Williams, SD Lyman, DM Anderson, T Pawson, ... Molecular and cellular biology 11 (6), 3043-3051, 1991 | 302 | 1991 |
| A point mutation in CD28 distinguishes proliferative signals from survival signals K Okkenhaug, L Wu, KM Garza, J La Rose, W Khoo, B Odermatt, TW Mak, ... Nature immunology 2 (4), 325-332, 2001 | 272 | 2001 |
| SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain M Kozlowski, L Larose, F Lee, DM Le, R Rottapel, KA Siminovitch Molecular and cellular biology 18 (4), 2089-2099, 1998 | 272 | 1998 |
| Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease S Guettler, J LaRose, E Petsalaki, G Gish, A Scotter, T Pawson, ... Cell 147 (6), 1340-1354, 2011 | 253 | 2011 |
| Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation P De Sepulveda, K Okkenhaug, J La Rose, RG Hawley, P Dubreuil, ... The EMBO journal 18 (4), 904-915, 1999 | 246 | 1999 |
| Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation P De Sepulveda, S Ilangumaran, R Rottapel Journal of Biological Chemistry 275 (19), 14005-14008, 2000 | 226 | 2000 |
| Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins ID Dimitriou, L Clemenza, AJ Scotter, G Chen, FM Guerra, R Rottapel Immunological reviews 224 (1), 265-283, 2008 | 210 | 2008 |
| The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor. F Galland, A Karamysheva, MJ Pebusque, JP Borg, R Rottapel, ... Oncogene 8 (5), 1233-1240, 1993 | 208 | 1993 |
| Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region PM Chan, S Ilangumaran, J La Rose, A Chakrabartty, R Rottapel Molecular and cellular biology 23 (9), 3067-3078, 2003 | 207 | 2003 |
| Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism N Levaot, O Voytyuk, I Dimitriou, F Sircoulomb, A Chandrakumar, ... Cell 147 (6), 1324-1339, 2011 | 198 | 2011 |
| CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly RG Jones, AR Elford, MJ Parsons, L Wu, CM Krawczyk, WC Yeh, ... The Journal of experimental medicine 196 (3), 335-348, 2002 | 197 | 2002 |
| CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer F Garçon, DT Patton, JL Emery, E Hirsch, R Rottapel, T Sasaki, ... Blood, The Journal of the American Society of Hematology 111 (3), 1464-1471, 2008 | 174 | 2008 |
| Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence R Haq, JD Brenton, M Takahashi, D Finan, R Rottapel, B Zanke Cancer research 62 (17), 5076-5082, 2002 | 174 | 2002 |
