| Crystal structure of bacteriophage T7 RNA polymerase at 3.3 Å resolution R Sousa, YJ Chung, JP Rose, BC Wang Nature 364 (6438), 593-599, 1993 | 523 | 1993 |
| Structural basis of interdomain communication in the Hsc70 chaperone J Jiang, K Prasad, EM Lafer, R Sousa Molecular cell 20 (4), 513-524, 2005 | 377 | 2005 |
| A mutant T7 RNA polymerase as a DNA polymerase. R Sousa, R Padilla The EMBO journal 14 (18), 4609-4621, 1995 | 341 | 1995 |
| Structural basis of J cochaperone binding and regulation of Hsp70 J Jiang, EG Maes, AB Taylor, L Wang, AP Hinck, EM Lafer, R Sousa Molecular cell 28 (3), 422-433, 2007 | 273 | 2007 |
| Structure of the Hsp110: Hsc70 nucleotide exchange machine JP Schuermann, J Jiang, J Cuellar, O Llorca, L Wang, LE Gimenez, S Jin, ... Molecular cell 31 (2), 232-243, 2008 | 267 | 2008 |
| A model for the mechanism of polymerase translocation R Guajardo, R Sousa Journal of molecular biology 265 (1), 8-19, 1997 | 249 | 1997 |
| A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non‐canonical NTPs R Padilla, R Sousa Nucleic acids research 30 (24), e138-e138, 2002 | 240 | 2002 |
| Structural and mechanistic relationships between nucleic acid polymerases R Sousa Trends in biochemical sciences 21 (5), 186-190, 1996 | 228 | 1996 |
| Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates R Sousa, JJ Jendrisak US Patent 5,849,546, 1998 | 204 | 1998 |
| Use of glycerol, polyols and other protein structure stabilizing agents in protein crystallization R Sousa Acta Crystallographica Section D: Biological Crystallography 51 (3), 271-277, 1995 | 199 | 1995 |
| Efficient synthesis of nucleic acids heavily modified with non-canonical ribose 2′-groups using a mutant T7 RNA polymerase (RNAP) R Padilla, R Sousa Nucleic acids research 27 (6), 1561-1563, 1999 | 181 | 1999 |
| T7 RNA polymerase. R Sousa, S Mukherjee Progress in nucleic acid research and molecular biology 73, 1-41, 2003 | 172 | 2003 |
| In Situ Hybridization Mapping of Glucocorticoid Receptor Messenger Ribonucleic Acid in Rat Brain RJ Sousa, NH Tannery, EM Lafer Molecular Endocrinology 3 (3), 481-494, 1989 | 141 | 1989 |
| Mechanism of ribose 2 ‘-group discrimination by an RNA polymerase Y Huang, F Eckstein, R Padilla, R Sousa Biochemistry 36 (27), 8231-8242, 1997 | 137 | 1997 |
| Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1 L Shaner, R Sousa, KA Morano Biochemistry 45 (50), 15075-15084, 2006 | 127 | 2006 |
| Mutations in T7 RNA polymerase that support the proposal for a common polymerase active site structure. G Bonner, D Patra, EM Lafer, R Sousa The EMBO journal 11 (10), 3767-3775, 1992 | 127 | 1992 |
| Misincorporation by wild-type and mutant T7 RNA polymerases: identification of interactions that reduce misincorporation rates by stabilizing the catalytically incompetent open … J Huang, LG Brieba, R Sousa Biochemistry 39 (38), 11571-11580, 2000 | 125 | 2000 |
| The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin J Cuéllar, J Martín-Benito, SHW Scheres, R Sousa, F Moro, ... Nature structural & molecular biology 15 (8), 858-864, 2008 | 124 | 2008 |
| Model for the mechanism of bacteriophage T7 RNAP transcription initiation and termination R Sousa, D Patra, EM Lafer Journal of molecular biology 224 (2), 319-334, 1992 | 120 | 1992 |
| Synthesis and applications of RNAs with position-selective labelling and mosaic composition Y Liu, E Holmstrom, J Zhang, P Yu, J Wang, MA Dyba, D Chen, J Ying, ... Nature 522 (7556), 368-372, 2015 | 111 | 2015 |
