José Manuel Andreu
José Manuel Andreu
Centro de Investigaciones Biologicas CSIC Madrid, Spain
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Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition
JF Diaz, JM Andreu
Biochemistry 32 (11), 2747-2755, 1993
4981993
Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action
M Abal, JM Andreu, I Barasoain
Current cancer drug targets 3 (3), 193-203, 2003
4022003
Low-resolution structures of proteins in solution retrieved from X-ray scattering with a genetic algorithm
P Chacon, F Moran, JF Diaz, E Pantos, JM Andreu
Biophysical Journal 74 (6), 2760-2775, 1998
3331998
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for …
DE Pryor, A O'Brate, G Bilcer, JF Díaz, Y Wang, Y Wang, M Kabaki, ...
Biochemistry 41 (29), 9109-9115, 2002
2702002
Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines
TN Gaitanos, RM Buey, JF Díaz, PT Northcote, P Teesdale-Spittle, ...
Cancer research 64 (15), 5063-5067, 2004
2332004
Novel polyphenol oxidase mined from a metagenome expression library of bovine rumen: biochemical properties, structural analysis, and phylogenetic relationships
A Beloqui, M Pita, J Polaina, A Martínez-Arias, OV Golyshina, ...
Journal of Biological Chemistry 281 (32), 22933-22942, 2006
2242006
Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity
RM Buey, I Barasoain, E Jackson, A Meyer, P Giannakakou, I Paterson, ...
Chemistry & biology 12 (12), 1269-1279, 2005
2192005
Magnesium-induced linear self-association of the FtsZ bacterial cell division protein monomer: the primary steps for FtsZ assembly
G Rivas, A López, J Mingorance, MJ Ferrándiz, S Zorrilla, AP Minton, ...
Journal of Biological Chemistry 275 (16), 11740-11749, 2000
1982000
Conformational states of tubulin liganded to colchicine, tropolone methyl ether, and podophyllotoxin
JM Andreu, SN Timasheff
Biochemistry 21 (25), 6465-6476, 1982
1981982
Essential cell division protein FtsZ assembles into one monomer-thick ribbons under conditions resembling the crowded intracellular environment
JM González, M Jiménez, M Vélez, J Mingorance, JM Andreu, M Vicente, ...
Journal of Biological Chemistry 278 (39), 37664-37671, 2003
1842003
Interaction of tubulin with single ring analogs of colchicine
JM Andreu, SN Timasheff
Biochemistry 21 (3), 534-543, 1982
1681982
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
RM Buey, E Calvo, I Barasoain, O Pineda, MC Edler, R Matesanz, ...
Nature chemical biology 3 (2), 117-125, 2007
1632007
Low resolution structure of microtubules in solution: Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in …
JM Andreu, J Bordas, JF Diaz, JG de Ancos, R Gil, FJ Medrano, ...
Journal of molecular biology 226 (1), 169-184, 1992
1611992
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
AE Prota, K Bargsten, JF Diaz, M Marsh, C Cuevas, M Liniger, C Neuhaus, ...
Proceedings of the National Academy of Sciences 111 (38), 13817-13821, 2014
1542014
Molecular recognition of taxol by microtubules: Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site
JF Dı́az, R Strobe, Y Engelborghs, AA Souto, JM Andreu
Journal of Biological Chemistry 275 (34), 26265-26276, 2000
1542000
Reconstruction of protein form with X-ray solution scattering and a genetic algorithm
P Chacón, JF Dıaz, F Morán, JM Andreu
Journal of molecular biology 299 (5), 1289-1302, 2000
1532000
Changes in microtubule protofilament number induced by taxol binding to an easily accessible site: internal microtubule dynamics
JF Dı́az, JM Valpuesta, P Chacón, G Diakun, JM Andreu
Journal of Biological Chemistry 273 (50), 33803-33810, 1998
1531998
The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation
JM Andreu, C Schaffner-Barbero, S Huecas, D Alonso, ...
Journal of Biological Chemistry 285 (19), 14239-14246, 2010
1482010
Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer
D Schlieper, MA Oliva, JM Andreu, J Löwe
Proceedings of the National Academy of Sciences 102 (26), 9170-9175, 2005
1382005
Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity
RM Buey, JF Dı́az, JM Andreu, A O'Brate, P Giannakakou, KC Nicolaou, ...
Chemistry & biology 11 (2), 225-236, 2004
1352004
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Artículos 1–20