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Nikesh Patel
Nikesh Patel
Verified email at leeds.ac.uk
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Cited by
Year
The HBV RNA pre-genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly
N Patel, SJ White, RF Thompson, R Bingham, EU Weiss, DP Maskell, ...
Nature Microbiology, 2017
852017
Revealing the density of encoded functions in a viral RNA
N Patel, EC Dykeman, RHA Coutts, GP Lomonossoff, DJ Rowlands, ...
Proceedings of the National Academy of Sciences 112 (7), 2227-2232, 2015
772015
Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein
S Tetter, N Terasaka, A Steinauer, RJ Bingham, S Clark, AJP Scott, ...
Science 372 (6547), 1220-1224, 2021
652021
Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends
N Patel, JM Atack, LD Finger, JC Exell, P Thompson, S Tsutakawa, ...
Nucleic acids research 40 (10), 4507-4519, 2012
562012
Rewriting nature’s assembly manual for a ssRNA virus
N Patel, E Wroblewski, G Leonov, SEV Phillips, R Tuma, R Twarock, ...
Proceedings of the National Academy of Sciences 114 (46), 12255-12260, 2017
522017
Bacteriophage MS2 genomic RNA encodes an assembly instruction manual for its capsid
PG Stockley, SJ White, E Dykeman, I Manfield, O Rolfsson, N Patel, ...
Bacteriophage 6 (1), e1157666, 2016
512016
Observation of unpaired substrate DNA in the flap endonuclease-1 active site
L David Finger, N Patel, A Beddows, L Ma, JC Exell, E Jardine, AC Jones, ...
Nucleic acids research 41 (21), 9839-9847, 2013
362013
An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies
F Fatehi, RJ Bingham, EC Dykeman, N Patel, PG Stockley, R Twarock
Viruses 13 (1), 11, 2021
172021
Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases
A Beddows, N Patel, LD Finger, JM Atack, DM Williams, JA Grasby
Chemical Communications 48 (71), 8895-8897, 2012
162012
Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing
N Patel, JC Exell, E Jardine, B Ombler, LD Finger, B Ciani, JA Grasby
Journal of Biological Chemistry 288 (47), 34239-34248, 2013
152013
In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus
N Patel, S Clark, EU Weiß, CP Mata, J Bohon, ER Farquhar, DP Maskell, ...
Communications biology 4 (1), 1-12, 2021
52021
Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands
N Patel, F Abulwerdi, F Fatehi, I Manfield, S Le Grice, JS Schneekloth, ...
bioRxiv, 2021
5*2021
Virus like particle
G Leonov, S White, P Stockley, N Patel, E Wroblewski, D Maskell, ...
US Patent App. 16/617,098, 2020
2020
An Intracellular Model of Hepatitis B Viral Infection: An In Sil-ico Platform for Comparing Therapeu-tic Strategies. Viruses 2021, 13, 11
F Fatehi, RJ Bingham, EC Dykeman, N Patel, PG Stockley, R Twarock
s Note: MDPI stays neu-tral with regard to jurisdictional claims in …, 2020
2020
Viral Genome Conformations and Contacts across Different Lifecycle Stages
PG Stockley, N Patel, EL Wroblewski, AJP Scott, CP Mata, ...
Multidisciplinary Digital Publishing Institute Proceedings 50 (1), 109, 2020
2020
Virus like particle
G LEONOV, S White, P Stockley, N PATEL, E WROBLEWSKI, ...
2018
A30 Recombination & evolution in two viral families: effective steps or a random walk?
R Bingham, G Leonov, N Patel, E Weiss, S White, E Dykeman, P Stockley, ...
Virus Evolution 3 (suppl_1), 2017
2017
Anti-viral therapy
R Twarock, E Dykeman, P Stockley, S White, A Barker, N Patel, S Butcher, ...
US Patent App. 14/916,945, 2016
2016
Mechanistic and Structural studies of the Helical Arch of Flap Endonuclease
N Patel
University of Sheffield, 2012
2012
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Articles 1–19