| Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9 D Paquet, D Kwart, A Chen, A Sproul, S Jacob, S Teo, KM Olsen, A Gregg, ... Nature 533 (7601), 125-129, 2016 | 1002 | 2016 |
| Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin N Exner, B Treske, D Paquet, K Holmström, C Schiesling, S Gispert, ... Journal of Neuroscience 27 (45), 12413-12418, 2007 | 620 | 2007 |
| A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation D Paquet, R Bhat, A Sydow, EM Mandelkow, S Berg, S Hellberg, J Fälting, ... The Journal of clinical investigation 119 (5), 1382-1395, 2009 | 304 | 2009 |
| A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP β-CTFs, not Aβ D Kwart, A Gregg, C Scheckel, EA Murphy, D Paquet, M Duffield, J Fak, ... Neuron 104 (2), 256-270. e5, 2019 | 246 | 2019 |
| Precise and efficient scarless genome editing in stem cells using CORRECT D Kwart, D Paquet, S Teo, M Tessier-Lavigne Nature protocols 12 (2), 329-354, 2017 | 116 | 2017 |
| Detection of deleterious on-target effects after HDR-mediated CRISPR editing I Weisheit, JA Kroeger, R Malik, J Klimmt, D Crusius, A Dannert, ... Cell reports 31 (8), 2020 | 106 | 2020 |
| In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system G Plucińska, D Paquet, A Hruscha, L Godinho, C Haass, B Schmid, ... Journal of Neuroscience 32 (46), 16203-16212, 2012 | 103 | 2012 |
| Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis FG Lafaille, O Harschnitz, YS Lee, P Zhang, ML Hasek, G Kerner, Y Itan, ... Nature medicine 25 (12), 1873-1884, 2019 | 99 | 2019 |
| Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish F van Bebber, D Paquet, A Hruscha, B Schmid, C Haass Neurobiology of disease 39 (3), 265-271, 2010 | 99 | 2010 |
| A reference human induced pluripotent stem cell line for large-scale collaborative studies CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendraat, L Peng, ... Cell Stem Cell 29 (12), 1685-1702. e22, 2022 | 76 | 2022 |
| Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy J Giustiniani, B Chambraud, E Sardin, O Dounane, K Guillemeau, ... Proceedings of the National Academy of Sciences 111 (12), 4584-4589, 2014 | 70 | 2014 |
| Parkin is protective against proteotoxic stress in a transgenic zebrafish model ME Fett, A Pilsl, D Paquet, F Van Bebber, C Haass, J Tatzelt, B Schmid, ... PloS one 5 (7), e11783, 2010 | 67 | 2010 |
| Autophagy induction by bexarotene promotes mitophagy in presenilin 1 familial Alzheimer’s disease iPSC-derived neural stem cells P Martín-Maestro, A Sproul, H Martinez, D Paquet, M Gerges, S Noggle, ... Molecular neurobiology 56, 8220-8236, 2019 | 56 | 2019 |
| Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency A Reifschneider, S Robinson, B van Lengerich, J Gnörich, T Logan, ... The EMBO Journal 41 (4), e109108, 2022 | 43 | 2022 |
| Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo D Paquet, B Schmid, C Haass Neurodegenerative Diseases 7 (1-3), 99-102, 2010 | 41 | 2010 |
| Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype C Soldati, I Lopez‐Fabuel, LG Wanderlingh, M Garcia‐Macia, ... EMBO molecular medicine 13 (10), e13742, 2021 | 34 | 2021 |
| TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease A Scotto Rosato, EK Krogsaeter, D Jaślan, C Abrahamian, S Montefusco, ... EMBO molecular medicine 14 (9), e15377, 2022 | 24 | 2022 |
| Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping I Weisheit, JA Kroeger, R Malik, B Wefers, P Lichtner, W Wurst, ... Nature protocols 16 (3), 1714-1739, 2021 | 24 | 2021 |
| Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia A Gottschlich, M Thomas, R Grünmeier, S Lesch, L Rohrbacher, V Igl, ... Nature biotechnology 41 (11), 1618-1632, 2023 | 23 | 2023 |
| Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer’s disease J Klimmt, A Dannert, D Paquet Current Opinion in Neurobiology 61, 96-104, 2020 | 14 | 2020 |
Scott A. NoggleThe New York Stem Cell FoundationVerified email at nyscf.org
