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Lluis Ballell
Lluis Ballell
Johnson & Johnson
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Year
Fueling open‐source drug discovery: 177 small‐molecule leads against tuberculosis
L Ballell, RH Bates, RJ Young, D Alvarez‐Gomez, E Alvarez‐Ruiz, ...
ChemMedChem 8 (2), 313-321, 2013
3562013
New small-molecule synthetic antimycobacterials
L Ballell, RA Field, K Duncan, RJ Young
Antimicrobial agents and chemotherapy 49 (6), 2153-2163, 2005
2492005
Identification of novel imidazo [1, 2-a] pyridine inhibitors targeting M. tuberculosis QcrB
KA Abrahams, JAG Cox, VL Spivey, NJ Loman, MJ Pallen, ...
PloS one 7 (12), e52951, 2012
2002012
Tetrahydropyrazolo [1, 5-a] pyrimidine-3-carboxamide and N-benzyl-6′, 7′-dihydrospiro [piperidine-4, 4′-thieno [3, 2-c] pyran] analogues with bactericidal efficacy against …
MJ Remuiñán, E Pérez-Herrán, J Rullás, C Alemparte, M Martínez-Hoyos, ...
PloS one 8 (4), e60933, 2013
1522013
New thiopyrazolo [3, 4-d] pyrimidine derivatives as anti-mycobacterial agents
L Ballell, RA Field, GAC Chung, RJ Young
Bioorganic & medicinal chemistry letters 17 (6), 1736-1740, 2007
1522007
β-Lactams against tuberculosis—new trick for an old dog?
AH Diacon, L van der Merwe, M Barnard, F von Groote-Bidlingmaier, ...
New England Journal of Medicine 375 (4), 393-394, 2016
1502016
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium …
L Encinas, H O’Keefe, M Neu, MJ Remuiñán, AM Patel, A Guardia, ...
Journal of Medicinal Chemistry 57 (4), 1276-1288, 2014
1212014
Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic
N Dhar, V Dubée, L Ballell, G Cuinet, JE Hugonnet, F Signorino-Gelo, ...
Antimicrobial agents and chemotherapy 59 (2), 1308-1319, 2015
1132015
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection
G Poce, RH Bates, S Alfonso, M Cocozza, GC Porretta, L Ballell, J Rullas, ...
PloS one 8 (2), e56980, 2013
1132013
A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus
C Dupont, A Viljoen, F Dubar, M Blaise, A Bernut, A Pawlik, C Bouchier, ...
Molecular microbiology 101 (3), 515-529, 2016
1082016
Identification of KasA as the cellular target of an anti-tubercular scaffold
KA Abrahams, C Chung, S Ghidelli-Disse, J Rullas, MJ Rebollo-López, ...
Nature communications 7 (1), 12581, 2016
912016
Repurposing clinically approved cephalosporins for tuberculosis therapy
S Ramón-García, R González del Río, AS Villarejo, GD Sweet, ...
Scientific reports 6 (1), 34293, 2016
882016
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis
Y Park, A Pacitto, T Bayliss, LAT Cleghorn, Z Wang, T Hartman, K Arora, ...
ACS infectious diseases 3 (1), 18-33, 2017
852017
A new chemical probe for proteomics of carbohydrate-binding proteins
L Ballell, KJ Alink, M Slijper, C Versluis, RMJ Liskamp, RJ Pieters
ChemBioChem 6 (2), 291-295, 2004
822004
Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis
R Sink, I Sosic, M Zivec, R Fernandez-Menendez, S Turk, S Pajk, ...
Journal of medicinal chemistry 58 (2), 613-624, 2015
772015
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
CA Machutta, CS Kollmann, KE Lind, X Bai, PF Chan, J Huang, L Ballell, ...
Nature communications 8 (1), 16081, 2017
722017
THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria
JAG Cox, KA Abrahams, C Alemparte, S Ghidelli-Disse, J Rullas, ...
Nature microbiology 1 (2), 1-10, 2016
692016
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor
M Martínez-Hoyos, E Perez-Herran, G Gulten, L Encinas, ...
EBioMedicine 8, 291-301, 2016
662016
Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase
SM Batt, M Cacho Izquierdo, J Castro Pichel, CJ Stubbs, ...
ACS Infectious Diseases 1 (12), 615-626, 2015
632015
Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen
A Ordas, RJ Raterink, F Cunningham, HJ Jansen, MI Wiweger, ...
Antimicrobial agents and chemotherapy 59 (2), 753-762, 2015
632015
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