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karel miettinen
karel miettinen
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The seco-iridoid pathway from Catharanthus roseus
K Miettinen, L Dong, N Navrot, T Schneider, V Burlat, J Pollier, L Woittiez, ...
Nature communications 5 (1), 3606, 2014
4532014
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
A Van Moerkercke, P Steensma, F Schweizer, J Pollier, I Gariboldi, ...
Proceedings of the National Academy of Sciences 112 (26), 8130-8135, 2015
1982015
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules
J Reed, MJ Stephenson, K Miettinen, B Brouwer, A Leveau, P Brett, ...
Metabolic Engineering 42, 185-193, 2017
1702017
Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated …
AJ Simkin, K Miettinen, P Claudel, V Burlat, G Guirimand, V Courdavault, ...
Phytochemistry 85, 36-43, 2013
1562013
An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids
P Arendt, K Miettinen, J Pollier, R De Rycke, N Callewaert, A Goossens
Metabolic engineering 40, 165-175, 2017
1532017
The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis
K Miettinen, J Pollier, D Buyst, P Arendt, R Csuk, S Sommerwerk, T Moses, ...
Nature communications 8 (1), 14153, 2017
1482017
The basic helix‐loop‐helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus
A Van Moerkercke, P Steensma, I Gariboldi, J Espoz, PC Purnama, ...
The Plant Journal 88 (1), 3-12, 2016
1112016
Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: similar activity but difference in subcellular localization
L Dong, K Miettinen, M Goedbloed, FWA Verstappen, A Voster, ...
Metabolic engineering 20, 198-211, 2013
912013
Iridoid synthase activity is common among the plant progesterone 5β-reductase family
J Munkert, J Pollier, K Miettinen, A Van Moerkercke, R Payne, F Müller-Uri, ...
Molecular plant 8 (1), 136-152, 2015
842015
The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis
K Miettinen, S Inigo, L Kreft, J Pollier, C De Bo, A Botzki, F Coppens, ...
Nucleic acids research 46 (D1), D586-D594, 2018
532018
Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol
NL Hansen, K Miettinen, Y Zhao, C Ignea, A Andreadelli, MH Raadam, ...
Microbial Cell Factories 19, 1-17, 2020
362020
A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
K Miettinen, N Leelahakorn, A Almeida, Y Zhao, LR Hansen, ...
Nature communications 13 (1), 3664, 2022
252022
Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins
V Tzin, JH Snyder, DS Yang, DV Huhman, BS Watson, SN Allen, Y Tang, ...
Metabolomics 15, 1-20, 2019
252019
Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol
MZ Saiman, K Miettinen, NR Mustafa, YH Choi, R Verpoorte, AE Schulte
Plant Cell, Tissue and Organ Culture (PCTOC) 134, 41-53, 2018
252018
Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks
C Ignea, MH Raadam, A Koutsaviti, Y Zhao, YT Duan, M Harizani, ...
Nature Communications 13 (1), 5188, 2022
242022
An Independent Evolutionary Origin for Insect Deterrent Cucurbitacins in Iberis amara
L Dong, A Almeida, J Pollier, B Khakimov, JE Bassard, K Miettinen, ...
Molecular Biology and Evolution 38 (11), 4659-4673, 2021
102021
Biosynthesis and biotechnological production of the anti-obesity agent celastrol
Y Zhao, NL Hansen, YT Duan, M Prasad, MS Motawia, BL Møller, ...
Nature Chemistry 15 (9), 1236-1246, 2023
92023
Elucidation of the secoiridoid pathway in Catharanthus roseus
K Miettinen
Chem. Pharm. Bull.(Tokyo) 55, 159-222, 2007
42007
Corrigendum: The seco-iridoid pathway from Catharanthus roseus
K Miettinen, L Dong, N Navrot, T Schneider, V Burlat, J Pollier, L Woittiez, ...
Nature Communications 5 (4175), 1, 2014
2014
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