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Luis Toledo
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ATR prohibits replication catastrophe by preventing global exhaustion of RPA
LI Toledo, M Altmeyer, MB Rask, C Lukas, DH Larsen, LK Povlsen, ...
Cell 155 (5), 1088-1103, 2013
8732013
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
LI Toledo, M Murga, R Zur, R Soria, A Rodriguez, S Martinez, J Oyarzabal, ...
Nature structural & molecular biology 18 (6), 721-727, 2011
5192011
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
M Murga, S Campaner, AJ Lopez-Contreras, LI Toledo, R Soria, ...
Nature structural & molecular biology 18 (12), 1331-1335, 2011
4142011
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
T Gudjonsson, M Altmeyer, V Savic, L Toledo, C Dinant, M Grøfte, ...
Cell 150 (4), 697-709, 2012
3482012
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
M Cuadrado, B Martinez-Pastor, M Murga, LI Toledo, P Gutierrez-Martinez, ...
The Journal of experimental medicine 203 (2), 297-303, 2006
3002006
Activation of the ATR kinase by the RPA-binding protein ETAA1
P Haahr, S Hoffmann, MAX Tollenaere, T Ho, LI Toledo, M Mann, ...
Nature cell biology 18 (11), 1196-1207, 2016
2622016
Replication catastrophe: when a checkpoint fails because of exhaustion
L Toledo, KJ Neelsen, J Lukas
Molecular cell 66 (6), 735-749, 2017
2182017
ATR signaling can drive cells into senescence in the absence of DNA breaks
LI Toledo, M Murga, P Gutierrez-Martinez, R Soria, O Fernandez-Capetillo
Genes & development 22 (3), 297-302, 2008
2142008
Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs
LI Toledo, M Murga, O Fernandez-Capetillo
Molecular oncology 5 (4), 368-373, 2011
2092011
The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage
DH Larsen, F Hari, JA Clapperton, M Gwerder, K Gutsche, M Altmeyer, ...
Nature cell biology 16 (8), 792-803, 2014
1542014
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
M Altmeyer, L Toledo, T Gudjonsson, M Grøfte, MB Rask, C Lukas, ...
Molecular cell 52 (2), 206-220, 2013
772013
Physiological tolerance to ssDNA enables strand uncoupling during DNA replication
A Ercilla, J Benada, S Amitash, G Zonderland, G Baldi, K Somyajit, F Ochs, ...
Cell Reports 30 (7), 2416-2429. e7, 2020
532020
CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells
S Choi, LI Toledo, O Fernandez-Capetillo, CJ Bakkenist
DNA repair 10 (10), 1000, 2011
182011
Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse
A Ercilla, S Feu, S Aranda, A Llopis, SH Brynjólfsdóttir, CS Sørensen, ...
Cellular and Molecular Life Sciences 77, 735-749, 2020
162020
The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
G Zonderland, R Vanzo, SA Gadi, E Martín-Doncel, F Coscia, A Mund, ...
Molecular Cell 82 (18), 3350-3365. e7, 2022
112022
VCP/p97 extracts DNA polymerase α/Primase from chromatin to limit the activation of the replication stress response
S Rodríguez-Acebes, R Martín-Rufo, A Fernández-Llorente, ...
bioRxiv, 2022.07. 25.501345, 2022
22022
Quantitative chromatin protein dynamics during replication origin firing in human cells
SA Gadi, IA Hendriks, CF Nielsen, P Popova, ID Hickson, ML Nielsen, ...
bioRxiv, 2024.04. 25.590934, 2024
2024
Current Subject Limits
T Gudjonsson, M Altmeyer, V Savic, L Toledo, C Dinant, M Grøfte, ...
Cell 150, 4, 0
Genomic Instability
LI Toledo, M Altmeyer, MB Rask, C Lukas, DH Larsen, LK Povlsen
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