| SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦ M Pacholec, JE Bleasdale, B Chrunyk, D Cunningham, D Flynn, ... Journal of Biological Chemistry 285 (11), 8340-8351, 2010 | 1055 | 2010 |
| A model for the mechanism of human topoisomerase I L Stewart, MR Redinbo, X Qiu, WGJ Hol, JJ Champoux Science 279 (5356), 1534-1541, 1998 | 899 | 1998 |
| Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia D Cunningham, DE Danley, KF Geoghegan, MC Griffor, JL Hawkins, ... Nature structural & molecular biology 14 (5), 413-419, 2007 | 558 | 2007 |
| Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules X Qiu, A Mistry, MJ Ammirati, BA Chrunyk, RW Clark, Y Cong, JS Culp, ... Nature structural & molecular biology 14 (2), 106-113, 2007 | 318 | 2007 |
| Delineating the role of cooperativity in the design of potent PROTACs for BTK A Zorba, C Nguyen, Y Xu, J Starr, K Borzilleri, J Smith, H Zhu, KA Farley, ... Proceedings of the National Academy of Sciences 115 (31), E7285-E7292, 2018 | 314 | 2018 |
| Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol D Cao, M Wang, X Qiu, D Liu, H Jiang, N Yang, RM Xu Genes & development 29 (12), 1316-1325, 2015 | 216 | 2015 |
| Discovery of a novel and potent class of FabI-directed antibacterial agents DJ Payne, WH Miller, V Berry, J Brosky, WJ Burgess, E Chen, ... Antimicrobial agents and chemotherapy 46 (10), 3118-3124, 2002 | 203 | 2002 |
| Crystal structure of β-ketoacyl-acyl carrier protein synthase III: a key condensing enzyme in bacterial fatty acid biosynthesis X Qiu, CA Janson, AK Konstantinidis, S Nwagwu, C Silverman, WW Smith, ... Journal of Biological Chemistry 274 (51), 36465-36471, 1999 | 201 | 1999 |
| Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK MA Seefeld, WH Miller, KA Newlander, WJ Burgess, WE DeWolf, ... Journal of medicinal chemistry 46 (9), 1627-1635, 2003 | 199 | 2003 |
| Unique fold and active site in cytomegalovirus protease X Qiu, JS Culp, AG DiLella, B Hellmig, SS Hoog, CA Janson, WW Smith, ... Nature 383 (6597), 275-279, 1996 | 199 | 1996 |
| Crystal structure of the herpes simplex virus 1 DNA polymerase S Liu, JD Knafels, JS Chang, GA Waszak, ET Baldwin, MR Deibel, ... Journal of Biological Chemistry 281 (26), 18193-18200, 2006 | 196 | 2006 |
| Refined structures of β-ketoacyl-acyl carrier protein synthase III X Qiu, CA Janson, WW Smith, M Head, J Lonsdale, AK Konstantinidis Journal of molecular biology 307 (1), 341-356, 2001 | 189 | 2001 |
| Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms MF Calabrese, F Rajamohan, MS Harris, NL Caspers, R Magyar, ... Structure 22 (8), 1161-1172, 2014 | 179 | 2014 |
| Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors X Qiu, CA Janson, WW Smith, SM Green, P McDevitt, K Johanson, ... Protein Science 10 (10), 2008-2016, 2001 | 165 | 2001 |
| Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein L Zhang, F Yan, S Zhang, D Lei, MA Charles, G Cavigiolio, M Oda, ... Nature chemical biology 8 (4), 342-349, 2012 | 155 | 2012 |
| Molecular basis for triclosan activity involves a flipping loop in the active site X Qiu, SS Abdel‐Meguid, CA Janson, RI Court, MG Smyth, DJ Payne Protein Science 8 (11), 2529-2532, 1999 | 150 | 1999 |
| Crystal structure of human osteoclast cathepsin K complex with E-64 B Zhao, CA Janson, BY Amegadzie, K D'Alessio, C Griffin, CR Hanning, ... Nature structural biology 4 (2), 109-111, 1997 | 150 | 1997 |
| Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI) WH Miller, MA Seefeld, KA Newlander, IN Uzinskas, WJ Burgess, ... Journal of medicinal chemistry 45 (15), 3246-3256, 2002 | 149 | 2002 |
| Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. BE Maryanoff, X Qiu, KP Padmanabhan, A Tulinsky, HR Almond Jr, ... Proceedings of the National Academy of Sciences 90 (17), 8048-8052, 1993 | 149 | 1993 |
| 1, 4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) DA Heerding, G Chan, WE DeWolf Jr, AP Fosberry, CA Janson, ... Bioorganic & medicinal chemistry letters 11 (16), 2061-2065, 2001 | 148 | 2001 |
Sherin Abdel-MeguidShifa Biomedical CorporationVerified email at shifabiomedical.com
