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Joshua Dempster
Joshua Dempster
Group Lead in Computational Science, Broad Institute
Dirección de correo verificada de broadinstitute.org
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Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325-330, 2018
7982018
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ...
Nature Communications 9 (1), 2018
3262018
Extracting biological insights from the project achilles genome-scale CRISPR screens in cancer cell lines
JM Dempster, J Rossen, M Kazachkova, J Pan, G Kugener, DE Root, ...
BioRxiv, 720243, 2019
2872019
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
JM Dempster, C Pacini, S Pantel, FM Behan, T Green, J Krill-Burger, ...
Nature communications 10 (1), 5817, 2019
1772019
Integrated cross-study datasets of genetic dependencies in cancer
C Pacini, JM Dempster, I Boyle, E Gonçalves, H Najgebauer, E Karakoc, ...
Nature communications 12 (1), 1661, 2021
1692021
Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects
JM Dempster, I Boyle, F Vazquez, DE Root, JS Boehm, WC Hahn, ...
Genome biology 22, 1-23, 2021
1532021
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
JR Prensner, OM Enache, V Luria, K Krug, KR Clauser, JM Dempster, ...
Nature biotechnology 39 (6), 697-704, 2021
942021
Targetable vulnerabilities in T-and NK-cell lymphomas identified through preclinical models
SY Ng, N Yoshida, AL Christie, M Ghandi, NV Dharia, J Dempster, ...
Nature communications 9 (1), 2024, 2018
932018
A first-generation pediatric cancer dependency map
NV Dharia, G Kugener, LM Guenther, CF Malone, AD Durbin, AL Hong, ...
Nature genetics 53 (4), 529-538, 2021
822021
Synthetic lethal interaction of SHOC2 depletion with MEK inhibition in RAS-driven cancers
R Sulahian, JJ Kwon, KH Walsh, E Pailler, TL Bosse, M Thaker, ...
Cell reports 29 (1), 118-134. e8, 2019
702019
Understanding degenerate ground states of a protected quantum circuit in the presence of disorder
JM Dempster, B Fu, DG Ferguson, DI Schuster, J Koch
Physical Review B 90 (9), 094518, 2014
662014
Aggregation of heterogeneously charged colloids
JM Dempster, M Olvera de la Cruz
Acs Nano 10 (6), 5909-5915, 2016
472016
Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer
DP Bondeson, BR Paolella, A Asfaw, MV Rothberg, TA Skipper, ...
Nature cancer 3 (6), 681-695, 2022
262022
Paramagnetic filaments in a fast precessing field: Planar versus helical conformations
P Vázquez-Montejo, JM Dempster, MO de la Cruz
Physical Review Materials 1 (6), 064402, 2017
262017
Contractile actuation and dynamical gel assembly of paramagnetic filaments in fast precessing fields
JM Dempster, P Vázquez-Montejo, MO De La Cruz
Physical Review E 95 (5), 052606, 2017
252017
BAF complex maintains glioma stem cells in pediatric H3K27M glioma
E Panditharatna, JG Marques, T Wang, MC Trissal, I Liu, L Jiang, A Beck, ...
Cancer discovery 12 (12), 2880-2905, 2022
232022
Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
CF Malone, NV Dharia, G Kugener, AB Forman, MV Rothberg, ...
Cancer discovery 11 (9), 2282-2299, 2021
232021
Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics
JM Dempster, JM Krill-Burger, JM McFarland, A Warren, JS Boehm, ...
BioRxiv, 2020.02. 21.959627, 2020
232020
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nat Commun. 2018; 9 (1): 4610
JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ...
Epub 2018/11/06. https://doi. org/10.1038/s41467-018-06916-5 PubMed Central …, 0
19
Comparative optimization of combinatorial CRISPR screens
R Li, O Klingbeil, D Monducci, MJ Young, DJ Rodriguez, Z Bayyat, ...
Nature Communications 13 (1), 2469, 2022
172022
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Artículos 1–20