David Lagares, Ph.D
David Lagares, Ph.D
Harvard Medical School
Verified email at - Homepage
Cited by
Cited by
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
F Liu, D Lagares, KM Choi, L Stopfer, A Marinković, V Vrbanac, CK Probst, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 308 (4 …, 2015
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
Y Zhang, F Vasheghani, Y Li, M Blati, K Simeone, H Fahmi, B Lussier, ...
Annals of the rheumatic diseases 74 (7), 1432-1440, 2015
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
B Hinz, D Lagares
Nature Reviews Rheumatology 16 (1), 11-31, 2020
Fibrosis—a lethal component of systemic sclerosis
YY Ho, D Lagares, AM Tager, M Kapoor
Nature Reviews Rheumatology 10 (7), 390-402, 2014
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
F Vasheghani, Y Zhang, YH Li, M Blati, H Fahmi, B Lussier, P Roughley, ...
Annals of the rheumatic diseases 74 (3), 569-578, 2015
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
D Lagares, O Busnadiego, RA García‐Fernández, M Kapoor, S Liu, ...
Arthritis & Rheumatism 64 (5), 1653-1664, 2012
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
D Lagares, A Santos, PE Grasberger, F Liu, CK Probst, RA Rahimi, ...
Science translational medicine 9 (420), eaal3765, 2017
Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis
AJ Haak, E Kostallari, D Sicard, G Ligresti, KM Choi, N Caporarello, ...
Science translational medicine 11 (516), eaau6296, 2019
Matrix stiffness: the conductor of organ fibrosis
A Santos, D Lagares
Current rheumatology reports 20, 1-13, 2018
Role of endothelin in the cardiovascular system
F Rodríguez-Pascual, O Busnadiego, D Lagares, S Lamas
Pharmacological research 63 (6), 463-472, 2011
Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability
F Rodríguez-Pascual, M Redondo-Horcajo, N Magán-Marchal, D Lagares, ...
Molecular and cellular biology, 2008
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
D Lagares, A Santos, A Franklin, AM Tager, A Pardo, BS Shea, B Wu, ...
Nature medicine, 2017
The Rho kinase isoforms ROCK1 and ROCK2 each contribute to the development of experimental pulmonary fibrosis
RS Knipe, CK Probst, D Lagares, A Franklin, JJ Spinney, PL Brazee, ...
American journal of respiratory cell and molecular biology 58 (4), 471-481, 2018
Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy
AR de Molina, D Gallego-Ortega, J Sarmentero-Estrada, D Lagares, ...
The international journal of biochemistry & cell biology 40 (9), 1753-1763, 2008
LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling
O Busnadiego, J González-Santamaría, D Lagares, J Guinea-Viniegra, ...
Molecular and cellular biology 33 (12), 2388-2401, 2013
Mechano-therapeutics: targeting mechanical signaling in fibrosis and tumor stroma
DJ Tschumperlin, D Lagares
Pharmacology & therapeutics 212, 107575, 2020
Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis
D Lagares, RA García‐Fernández, CL Jiménez, N Magán‐Marchal, ...
Arthritis & Rheumatism 62 (3), 878-889, 2010
Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis
W Merkt, M Bueno, AL Mora, D Lagares
Seminars in cell & developmental biology 101, 104-110, 2020
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
T Sato, S Verma, CDC Andrade, M Omeara, N Campbell, JS Wang, ...
Nature communications 11 (1), 3282, 2020
Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth …
N Sakai, J Chun, JS Duffield, D Lagares, T Wada, AD Luster, AM Tager
Kidney international 91 (3), 628-641, 2017
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