| Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors K Brejc, WJ Van Dijk, RV Klaassen, M Schuurmans, J Van Der Oost, ... Nature 411 (6835), 269-276, 2001 | 2237 | 2001 |
| A genomic and functional inventory of deubiquitinating enzymes SMB Nijman, MPA Luna-Vargas, A Velds, TR Brummelkamp, AMG Dirac, ... Cell 123 (5), 773-786, 2005 | 2128 | 2005 |
| Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures PHN Celie, SE van Rossum-Fikkert, WJ van Dijk, K Brejc, AB Smit, ... Neuron 41 (6), 907-914, 2004 | 970 | 2004 |
| Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein K Brejc, TK Sixma, PA Kitts, SR Kain, RY Tsien, M Ormö, SJ Remington Proceedings of the National Academy of Sciences 94 (6), 2306-2311, 1997 | 962 | 1997 |
| The crystal structure of DNA mismatch repair protein MutS binding to a G· T mismatch MH Lamers, A Perrakis, JH Enzlin, HHK Winterwerp, N de Wind, ... Nature 407 (6805), 711-717, 2000 | 782 | 2000 |
| Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli TK Sixma, SE Pronk, KH Kalk, ES Wartna, BAM van Zanten, B Witholt, ... Nature 351 (6325), 371-377, 1991 | 708 | 1991 |
| A glia-derived acetylcholine-binding protein that modulates synaptic transmission AB Smit, NI Syed, D Schaap, J van Minnen, J Klumperman, KS Kits, ... Nature 411 (6835), 261-268, 2001 | 684 | 2001 |
| RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling F Mattiroli, JHA Vissers, WJ van Dijk, P Ikpa, E Citterio, W Vermeulen, ... Cell 150 (6), 1182-1195, 2012 | 683 | 2012 |
| wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models A Perrakis, TK Sixma, KS Wilson, VS Lamzin Acta Crystallographica Section D: Biological Crystallography 53 (4), 448-455, 1997 | 645 | 1997 |
| Structure and E3‐ligase activity of the Ring–Ring complex of Polycomb proteins Bmi1 and Ring1b G Buchwald, P van der Stoop, O Weichenrieder, A Perrakis, ... The EMBO journal 25 (11), 2465-2474, 2006 | 490 | 2006 |
| Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage T Thorslund, A Ripplinger, S Hoffmann, T Wild, M Uckelmann, ... Nature 527 (7578), 389-393, 2015 | 409 | 2015 |
| Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin TK Sixma, KH Kalk, BAM van Zanten, Z Dauter, J Kingma, B Witholt, ... Journal of molecular biology 230 (3), 890-918, 1993 | 396 | 1993 |
| Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant PHN Celie, IE Kasheverov, DY Mordvintsev, RC Hogg, P van Nierop, ... Nature structural & molecular biology 12 (7), 582-588, 2005 | 388 | 2005 |
| RNF8‐and RNF168‐dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites FA Mallette, F Mattiroli, G Cui, LC Young, MJ Hendzel, G Mer, TK Sixma, ... The EMBO journal 31 (8), 1865-1878, 2012 | 382 | 2012 |
| Chemical synthesis of ubiquitin, ubiquitin‐based probes, and diubiquitin F El Oualid, R Merkx, R Ekkebus, DS Hameed, JJ Smit, A de Jong, ... Angewandte Chemie 122 (52), 10347-10351, 2010 | 327 | 2010 |
| Ubc9 sumoylation regulates SUMO target discrimination P Knipscheer, A Flotho, H Klug, JV Olsen, WJ van Dijk, A Fish, ... Molecular cell 31 (3), 371-382, 2008 | 267 | 2008 |
| SUMO modification of the ubiquitin-conjugating enzyme E2-25K A Pichler, P Knipscheer, E Oberhofer, WJ Van Dijk, R Körner, JV Olsen, ... Nature structural & molecular biology 12 (3), 264-269, 2005 | 266 | 2005 |
| Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase AC Faesen, AMG Dirac, A Shanmugham, H Ovaa, A Perrakis, TK Sixma Molecular cell 44 (1), 147-159, 2011 | 257 | 2011 |
| Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP C Ulens, RC Hogg, PH Celie, D Bertrand, V Tsetlin, AB Smit, TK Sixma Proceedings of the National Academy of Sciences 103 (10), 3615-3620, 2006 | 257 | 2006 |
| Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography TK Sixma, SME Pronk, KH Kalk, BAM van Zanten, AM Berghuis, WGJ Hol Nature 355 (6360), 561-564, 1992 | 251 | 1992 |
