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Karthik Lingineni
Karthik Lingineni
University of Florida, Center for Pharmacometrics and Systems Pharmacology
Dirección de correo verificada de ufl.edu
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The role of multidrug resistance protein (MRP-1) as an active efflux transporter on blood–brain barrier (BBB) permeability
K Lingineni, V Belekar, SR Tangadpalliwar, P Garg
Molecular diversity 21, 355-365, 2017
612017
Classification of breast cancer resistant protein (BCRP) inhibitors and non-inhibitors using machine learning approaches
V Belekar, K Lingineni, P Garg
Combinatorial Chemistry & High Throughput Screening 18 (5), 476-485, 2015
212015
Development of a model‐based clinical trial simulation platform to optimize the design of clinical trials for Duchenne muscular dystrophy
K Lingineni, V Aggarwal, JF Morales, DJ Conrado, D Corey, C Vong, ...
CPT: Pharmacometrics & Systems Pharmacology 11 (3), 318-332, 2022
172022
Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores
CD Thomas, SA Mosley, S Kim, K Lingineni, N El Rouby, TY Langaee, ...
CPT: Pharmacometrics & Systems Pharmacology 9 (12), 678-685, 2020
152020
Quantitative assessment of levonorgestrel binding partner interplay and drug‐drug interactions using physiologically based pharmacokinetic modeling
B Cicali, K Lingineni, R Cristofoletti, T Wendl, J Hoechel, H Wiesinger, ...
CPT: Pharmacometrics & Systems Pharmacology 10 (1), 48-58, 2021
112021
Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate
N Farhan, R Cristofoletti, S Basu, S Kim, K Lingineni, S Jiang, JD Brown, ...
CPT: Pharmacometrics & Systems Pharmacology 10 (3), 199-210, 2021
92021
Quantitative Benefit–Risk Assessment of P‐gp–Mediated Drug–Drug Interactions of Dabigatran Coadministered With Pharmacokinetic Enhancers in Patients With Renal Impairment
K Lingineni, N Farhan, S Kim, R Cristofoletti, LA Gordon, P Kumar, ...
Clinical Pharmacology & Therapeutics 109 (1), 193-200, 2021
92021
Evaluating the clinical impact of formulation variability: a metoprolol extended‐release case study
S Kim, VD Sharma, K Lingineni, N Farhan, L Fang, L Zhao, JD Brown, ...
The Journal of Clinical Pharmacology 59 (9), 1266-1274, 2019
92019
Predicting cost‐effectiveness of generic vs. brand dabigatran using pharmacometric estimates among patients with atrial fibrillation in the United States
CY Wang, PN Pham, S Kim, K Lingineni, S Schmidt, V Diaby, J Brown
Clinical and Translational Science 13 (2), 352-361, 2020
62020
Determining the exposure threshold for levonorgestrel efficacy using an integrated model based meta‐analysis approach
K Lingineni, A Chaturvedula, B Cicali, R Cristofoletti, T Wendl, J Hoechel, ...
Clinical Pharmacology & Therapeutics 111 (2), 509-518, 2022
52022
Development and verification of a body weight–directed disease trial model for glucose homeostasis
N Farhan, I Gebert, Y Xing, K Wieser, K Lingineni, X Ma, JY Chien, ...
The Journal of Clinical Pharmacology 61 (2), 234-243, 2021
32021
Development of a Translational Exposure‐Bracketing Approach to Streamline the Development of Hormonal Contraceptive Drug Products
B Cicali, L Da Silva, A Sarayani, K Lingineni, M Pressly, S Kim, T Wendl, ...
Clinical Pharmacology & Therapeutics 112 (4), 909-916, 2022
22022
A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence
SA Mosley, S Kim, N El Rouby, K Lingineni, VV Esteban, Y Gong, Y Chen, ...
Clinical and Translational Science 15 (7), 1764-1775, 2022
12022
P146 A clinical trial simulation tool to accelerate trial design in DMD: description of the traphical user interface features and applications
R Belfiore-Oshan, V Aggarwal, J Wilk, M Pauley, D Corey, K Romero, ...
Neuromuscular Disorders 33, S84, 2023
2023
VP. 85 C-Path's Duchenne Regulatory Science Consortium: Accelerating drug development for Duchenne muscular dystrophy
R Belfiore-Oshan, V Aggarwal, S Sivakumaran, D Corey, C Ollivier, ...
Neuromuscular Disorders 32, S128, 2022
2022
DMD–BIOMARKERS & OUTCOME MEASURES: P. 126 Development of a regulatory-ready clinical trial simulation tool for Duchenne muscular dystrophy
J Larkindale, S Kim, K LIngineni, J Morales, S Schmidt, D Corey, ...
Neuromuscular Disorders 30, S83, 2020
2020
MUSCLE IMAGING–MRI: P. 161 Development of clinical trial simulation tools for Duchenne muscular dystrophy using magnetic resonance biomarkers
K Vandenborne, S Kim, R Willcocks, J Morales, K Lingineni, A Barnard, ...
Neuromuscular Disorders 30, S93-S94, 2020
2020
PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELING OF CLOPIDOGREL AND ITS ACTIVE METABOLITE WHEN ADMINISTERED ALONE OR DURING CONCOMITANT ADMINISTRATION WITH ESOMEPRAZOLE …
V Michaud, K Lingineni, J Turgeon, S Schmidt
CLINICAL PHARMACOLOGY & THERAPEUTICS 107, S113-S113, 2020
2020
TOWARDS ACHIEVING REGULATORY ENDORSEMENT OF A DISEASE PROGRESSION MODEL-BASED CLINICAL TRIAL SIMULATION TOOL FOR DUCHENNE MUSCULAR DYSTROPHY-MODEL OF PROGRESSION OF FORCED …
K Lingineni, D Conrado, D Corey, M Hill, C Vong, J Burton, J Larkindale, ...
CLINICAL PHARMACOLOGY & THERAPEUTICS 107, S78-S78, 2020
2020
DEVELOPMENT AND VERIFICATION OF A LEVONORGESTREL PBPK MODEL FOR ENZYME-MEDIATED DRUG INTERACTION STUDIES.
B Cicali, R Cristofoletti, T Wendl, K Lingineni, J Hoechel, H Wiesinger, ...
CLINICAL PHARMACOLOGY & THERAPEUTICS 107, S64-S64, 2020
2020
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