Jeffrey S. Flier
Jeffrey S. Flier
Dean, Harvard Medical School
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Adipose tissue as an endocrine organ
EE Kershaw, JS Flier
The Journal of Clinical Endocrinology & Metabolism 89 (6), 2548-2556, 2004
Obesity and insulin resistance
BB Kahn, JS Flier
The Journal of clinical investigation 106 (4), 473-481, 2000
TLR4 links innate immunity and fatty acid–induced insulin resistance
H Shi, MV Kokoeva, K Inouye, I Tzameli, H Yin, JS Flier
The Journal of clinical investigation 116 (11), 3015-3025, 2006
Role of leptin in the neuroendocrine response to fasting
RS Ahima, D Prabakaran, C Mantzoros, D Qu, B Lowell, E Maratos-Flier, ...
Nature 382 (6588), 250-252, 1996
Obesity and the regulation of energy balance
BM Spiegelman, JS Flier
cell 104 (4), 531-543, 2001
RS Ahima, JS Flier
Annual review of physiology 62 (1), 413-437, 2000
A transgenic model of visceral obesity and the metabolic syndrome
L Szidonya, L Hunyady
Trends in Endocrinology & Metabolism 13 (3), 98, 2002
Adipose tissue as an endocrine organ
RS Ahima, JS Flier
Trends in Endocrinology & Metabolism 11 (8), 327-332, 2000
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
RC Frederich, A Hamann, S Anderson, B Löllmann, BB Lowell, JS Flier
Nature medicine 1 (12), 1311-1314, 1995
Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
MK Badman, P Pissios, AR Kennedy, G Koukos, JS Flier, E Maratos-Flier
Cell metabolism 5 (6), 426-437, 2007
Adipogenesis and obesity: rounding out the big picture
BM Spiegelman, JS Flier
Cell 87 (3), 377-389, 1996
Obesity wars: molecular progress confronts an expanding epidemic
JS Flier
Cell 116 (2), 337-350, 2004
The organization, promoter analysis, and expression of the human PPARγ gene
L Fajas, D Auboeuf, E Raspé, K Schoonjans, AM Lefebvre, R Saladin, ...
Journal of Biological Chemistry 272 (30), 18779-18789, 1997
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
S Kleiner, N Douris, EC Fox, RJ Mepani, F Verdeguer, J Wu, ...
Genes & development 26 (3), 271-281, 2012
The syndromes of insulin resistance and acanthosis nigricans: insulin-receptor disorders in man
CR Kahn, JS Flier, RS Bar, JA Archer, P Gorden, MM Martin, J Roth
New England Journal of Medicine 294 (14), 739-745, 1976
Mice lacking melanin-concentrating hormone are hypophagic and lean
M Shimada, NA Tritos, BB Lowell, JS Flier, E Maratos-Flier
Nature 396 (6712), 670-674, 1998
Distributions of leptin receptor mRNA isoforms in the rat brain
JK Elmquist, C Bjørbæk, RS Ahima, JS Flier, CB Saper
Journal of Comparative Neurology 395 (4), 535-547, 1998
Identification of SOCS-3 as a potential mediator of central leptin resistance
C Bjørbæk, JK Elmquist, JD Frantz, SE Shoelson, JS Flier
Molecular cell 1 (4), 619-625, 1998
Insulin resistance—mechanisms, syndromes, and implications
DE Moller, JS Flier
New England Journal of Medicine 325 (13), 938-948, 1991
Divergent signaling capacities of the long and short isoforms of the leptin receptor
C Bjørbæk, S Uotani, B Da Silva, JS Flier
Journal of Biological Chemistry 272 (51), 32686-32695, 1997
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