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Alexandre Wohlkonig
Alexandre Wohlkonig
Staff Scientist
Dirección de correo verificada de vub.be
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Type IIA topoisomerase inhibition by a new class of antibacterial agents
BD Bax, PF Chan, DS Eggleston, A Fosberry, DR Gentry, F Gorrec, ...
Nature 466 (7309), 935-940, 2010
8132010
A general protocol for the generation of Nanobodies for structural biology
E Pardon, T Laeremans, S Triest, SGF Rasmussen, A Wohlkönig, A Ruf, ...
Nature protocols 9 (3), 674-693, 2014
7072014
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
A Wohlkonig, PF Chan, AP Fosberry, P Homes, J Huang, M Kranz, ...
Nature structural & molecular biology 17 (9), 1152-1153, 2010
3282010
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420
N Blondiaux, M Moune, M Desroses, R Frita, M Flipo, V Mathys, ...
Science 355 (6330), 1206-1211, 2017
1382017
Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody
RNN Abskharon, G Giachin, A Wohlkonig, SH Soror, E Pardon, ...
Journal of the American Chemical Society 136 (3), 937-944, 2014
1302014
Structural Relationships in the Lysozyme Superfamily: Significant Evidence for Glycoside Hydrolase Signature Motifs
A Wohlkönig, J Huet, Y Looze, R Wintjens
PloS one 5 (11), e15388, 2010
1192010
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
T Uchański, S Masiulis, B Fischer, V Kalichuk, U López-Sánchez, ...
Nature methods 18 (1), 60-68, 2021
982021
Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1, 2, 4-Oxadiazole EthR …
M Flipo, M Desroses, N Lecat-Guillet, B Villemagne, N Blondiaux, ...
Journal of Medicinal Chemistry, 2011
932011
An improved yeast surface display platform for the screening of nanobody immune libraries
T Uchański, T Zögg, J Yin, D Yuan, A Wohlkönig, B Fischer, ...
Scientific reports 9 (1), 382, 2019
812019
Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking …
B Villemagne, M Flipo, N Blondiaux, C Crauste, S Malaquin, F Leroux, ...
Journal of medicinal chemistry 57 (11), 4876-4888, 2014
732014
Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors
A Joncour, N Desroy, C Housseman, X Bock, N Bienvenu, L Cherel, ...
Journal of Medicinal Chemistry 60 (17), 7371-7392, 2017
542017
Discovery of novel N-phenyl-phenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining High-Throughput Screening and Synthesis.
M Flipo, N Willand, N Lecat-Guillet, C Hounsou, D Matthieu, F Leroux, ...
Journal of Medicinal Chemistry, 2012
542012
Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies
F Dubar, R Wintjens, ÉS Martins-Duarte, RC Vommaro, W de Souza, ...
Med. Chem. Commun., 2011
452011
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands
X Carette, N Blondiaux, E Willery, S Hoos, N Lecat-Guillet, Z Lens, ...
Nucleic Acids Research, 2011
402011
Recombinant Human Prion Protein Inhibits Prion Propagation in vitro
J Yuan, YA Zhan, R Abskharon, X Xiao, MC Martinez, X Zhou, G Kneale, ...
Scientific reports 3 (1), 2911, 2013
392013
The peptidyl–prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins
H Hodak, A Wohlkönig, C Smet-Nocca, H Drobecq, JM Wieruszeski, ...
Journal of molecular biology 376 (2), 414-426, 2008
382008
Biphenyl 2,3′,4,5′,6‐pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes
F Vandeput, L Combettes, SJ Mills, K Backers, A Wohlkönig, JB Parys, ...
The FASEB journal 21 (7), 1481-1491, 2007
352007
Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission
E Dupré, A Wohlkonig, J Herrou, C Locht, F Jacob-Dubuisson, R Antoine
BMC microbiology 13, 1-12, 2013
292013
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
R Abskharon, F Wang, A Wohlkonig, J Ruan, S Soror, G Giachin, ...
PLoS Pathogens 15 (12), e1008139, 2019
282019
A novel expression system for production of soluble prion proteins in E. coli
RNN Abskharon, S Ramboarina, H El Hassan, W Gad, MI Apostol, ...
Microbial Cell Factories 11 (1), 6, 2012
282012
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
Artículos 1–20