| The E2F1–3 transcription factors are essential for cellular proliferation L Wu, C Timmers, B Maiti, HI Saavedra, L Sang, GT Chong, F Nuckolls, ... Nature 414 (6862), 457-462, 2001 | 760 | 2001 |
| Extra-embryonic function of Rb is essential for embryonic development and viability L Wu, A De Bruin, HI Saavedra, M Starovic, A Trimboli, Y Yang, J Opavska, ... Nature 421 (6926), 942-947, 2003 | 442 | 2003 |
| Myc requires distinct E2F activities to induce S phase and apoptosis G Leone, R Sears, E Huang, R Rempel, F Nuckolls, CH Park, ... Molecular cell 8 (1), 105-113, 2001 | 325 | 2001 |
| Aberrant regulation of survivin by the RB/E2F family of proteins Y Jiang, HI Saavedra, MP Holloway, G Leone, RA Altura Journal of Biological Chemistry 279 (39), 40511-40520, 2004 | 233 | 2004 |
| The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway HI Saavedra, JA Knauf, JM Shirokawa, J Wang, B Ouyang, R Elisei, ... Oncogene 19 (34), 3948-3954, 2000 | 224 | 2000 |
| Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice A De Bruin, L Wu, HI Saavedra, P Wilson, Y Yang, TJ Rosol, M Weinstein, ... Proceedings of the National Academy of Sciences 100 (11), 6546-6551, 2003 | 167 | 2003 |
| Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance M Marina, HI Saavedra Frontiers in bioscience (Landmark edition) 19, 352, 2014 | 134 | 2014 |
| E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop C Timmers, N Sharma, R Opavsky, B Maiti, L Wu, J Wu, D Orringer, ... Molecular and cellular biology, 2007 | 132 | 2007 |
| Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb HI Saavedra, L Wu, A De Bruin, C Timmers, TJ Rosol, M Weinstein, ... | 127 | 2002 |
| MAPK mediates RAS-induced chromosome instability HI Saavedra, K Fukasawa, CW Conn, PJ Stambrook Journal of Biological Chemistry 274 (53), 38083-38090, 1999 | 112 | 1999 |
| Inactivation of E2F3 results in centrosome amplification HI Saavedra, B Maiti, C Timmers, R Altura, Y Tokuyama, K Fukasawa, ... Cancer cell 3 (4), 333-346, 2003 | 105 | 2003 |
| Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells AM Adon, X Zeng, MK Harrison, S Sannem, H Kiyokawa, P Kaldis, ... Molecular and cellular biology, 2010 | 104 | 2010 |
| The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2 X Zeng, FY Shaikh, MK Harrison, AM Adon, AJ Trimboli, KA Carroll, ... Oncogene 29 (36), 5103-5112, 2010 | 92 | 2010 |
| Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation N Sharma, C Timmers, P Trikha, HI Saavedra, A Obery, G Leone Journal of biological chemistry 281 (47), 36124-36131, 2006 | 89 | 2006 |
| Conditional apoptosis induced by oncogenic ras in thyroid cells JM Shirokawa, R Elisei, JA Knauf, T Hara, J Wang, HI Saavedra, JA Fagin Molecular Endocrinology 14 (11), 1725-1738, 2000 | 69 | 2000 |
| Alloantigen gene therapy for squamous cell carcinoma of the head and neck: results of a phase 1 trial LL Gleich, JL Gluckman, S Armstrong, PW Biddinger, MA Miller, ... Archives of Otolaryngology–Head & Neck Surgery 124 (10), 1097-1104, 1998 | 66 | 1998 |
| Management implications of evaluating the N2 and N3 neck after organ preservation therapy MD Strasser, LL Gleich, MA Miller, HI Saavedra, JL Gluckman The Laryngoscope 109 (11), 1776-1780, 1999 | 60 | 1999 |
| TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer JL King, B Zhang, Y Li, KP Li, JJ Ni, HI Saavedra, JT Dong Oncogenesis 7 (9), 69, 2018 | 59 | 2018 |
| E2F activators signal and maintain centrosome amplification in breast cancer cells MY Lee, CS Moreno, HI Saavedra Molecular and Cellular Biology, 2014 | 56 | 2014 |
| Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model MK Harrison Pitner, HI Saavedra PLoS One 8 (6), e65971, 2013 | 46 | 2013 |
