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Kimberly Scearce-Levie
Kimberly Scearce-Levie
Other namesKimberly Scearce
Cajal Neuroscience
Verified email at cajalneuro.com
Title
Cited by
Cited by
Year
Reducing endogenous tau ameliorates amyloid ß-induced deficits in an Alzheimer's disease mouse model
ED Roberson, K Scearce-Levie, JJ Palop, F Yan, IH Cheng, T Wu, ...
Science 316 (5825), 750-754, 2007
23152007
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration
D Zwilling, SY Huang, KV Sathyasaikumar, FM Notarangelo, P Guidetti, ...
Cell 145 (6), 863-874, 2011
5202011
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
IH Cheng, K Scearce-Levie, J Legleiter, JJ Palop, H Gerstein, N Bien-Ly, ...
Journal of Biological Chemistry 282 (33), 23818-23828, 2007
5012007
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
FM Harris, WJ Brecht, Q Xu, I Tesseur, L Kekonius, T Wyss-Coray, JD Fish, ...
Proceedings of the National Academy of Sciences 100 (19), 10966-10971, 2003
4332003
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
BA Rocha, K Scearce-Levie, JJ Lucas, N Hiroi, N Castanon, JC Crabbe, ...
Nature 393 (6681), 175-178, 1998
4151998
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations
Z Sheng, S Zhang, D Bustos, T Kleinheinz, CE Le Pichon, SL Dominguez, ...
Science translational medicine 4 (164), 164ra161-164ra161, 2012
3962012
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
RO Sanchez-Mejia, JW Newman, S Toh, GQ Yu, Y Zhou, B Halabisky, ...
Nature neuroscience 11 (11), 1311-1318, 2008
3852008
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease
J Chin, JJ Palop, J Puoliväli, C Massaro, N Bien-Ly, H Gerstein, ...
Journal of Neuroscience 25 (42), 9694-9703, 2005
3672005
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
YJ Yu, JK Atwal, Y Zhang, RK Tong, KR Wildsmith, C Tan, N Bien-Ly, ...
Science translational medicine 6 (261), 261ra154-261ra154, 2014
3652014
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
JK Atwal, Y Chen, C Chiu, DL Mortensen, WJ Meilandt, Y Liu, CE Heise, ...
Science translational medicine 3 (84), 84ra43-84ra43, 2011
2992011
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein …
L Esposito, J Raber, L Kekonius, F Yan, GQ Yu, N Bien-Ly, J Puoliväli, ...
Journal of Neuroscience 26 (19), 5167-5179, 2006
2792006
Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
JA Couch, YJ Yu, Y Zhang, JM Tarrant, RN Fuji, WJ Meilandt, H Solanoy, ...
Science translational medicine 5 (183), 183ra57-183ra57, 2013
2592013
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Aβ oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
WJ Meilandt, M Cisse, K Ho, T Wu, LA Esposito, K Scearce-Levie, ...
Journal of Neuroscience 29 (7), 1977-1986, 2009
1862009
Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice
JJ Lucas, A Yamamoto, K Scearce-Levie, F Saudou, R Hen
Journal of Neuroscience 18 (14), 5537-5544, 1998
1771998
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors
AA Estrada, X Liu, C Baker-Glenn, A Beresford, DJ Burdick, M Chambers, ...
Journal of medicinal chemistry 55 (22), 9416-9433, 2012
1562012
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
CE Le Pichon, WJ Meilandt, S Dominguez, H Solanoy, H Lin, H Ngu, ...
Science translational medicine 9 (403), eaag0394, 2017
1322017
Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors
AA Estrada, BK Chan, C Baker-Glenn, A Beresford, DJ Burdick, ...
Journal of medicinal chemistry 57 (3), 921-936, 2014
1322014
Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies
DW Shineman, GS Basi, JL Bizon, CA Colton, BD Greenberg, BA Hollister, ...
Alzheimer's research & therapy 3, 1-13, 2011
1322011
Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout mice
SC Dulawa, R Hen, K Scearce-Levie, MA Geyer
Psychopharmacology 132, 125-134, 1997
1321997
Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement
SH Lee, CE Le Pichon, O Adolfsson, V Gafner, M Pihlgren, H Lin, ...
Cell reports 16 (6), 1690-1700, 2016
1182016
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