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Dr Paul S Sharp
Dr Paul S Sharp
Medicine Discovery Catapult
Dirección de correo verificada de md.catapult.org.uk - Página principal
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LRP-1-mediated intracellular antibody delivery to the Central Nervous System
X Tian, S Nyberg, PS Sharp, J Madsen, N Daneshpour, SP Armes, ...
Scientific reports 5 (1), 11990, 2015
1552015
Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer
H Foster, PS Sharp, T Athanasopoulos, C Trollet, IR Graham, K Foster, ...
Molecular therapy 16 (11), 1825-1832, 2008
1402008
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
PS Sharp, MT Akbar, S Bouri, A Senda, K Joshi, HJ Chen, DS Latchman, ...
Neurobiology of disease 30 (1), 42-55, 2008
1322008
Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)
RJ Mead, EJ Bennett, AJ Kennerley, P Sharp, C Sunyach, P Kasher, ...
PloS one 6 (8), e23244, 2011
1032011
Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice
A Malerba, PS Sharp, IR Graham, V Arechavala-Gomeza, K Foster, ...
Molecular Therapy 19 (2), 345-354, 2011
1032011
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy
PS Sharp, H Bye-a-Jee, DJ Wells
Molecular Therapy 19 (1), 165-171, 2011
912011
Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice
HM Kaneb, PS Sharp, N Rahmani-Kondori, DJ Wells
PloS one 6 (9), e24189, 2011
862011
The effect of peripheral nerve injury on disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis
PS Sharp, JRT Dick, L Greensmith
Neuroscience 130 (4), 897-910, 2005
832005
Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function
P Sharp, M Krishnan, O Pullar, R Navarrete, D Wells, J de Belleroche
Experimental neurology 198 (2), 511-518, 2006
652006
Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function
P Sharp, M Krishnan, O Pullar, R Navarrete, D Wells, J de Belleroche
Experimental neurology 198 (2), 511-518, 2006
652006
Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease
KE Ameen‐Ali, SB Wharton, JE Simpson, PR Heath, P Sharp, J Berwick
Neuropathology and Applied Neurobiology 43 (7), 553-570, 2017
622017
Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime
PS Sharp, K Shaw, L Boorman, S Harris, AJ Kennerley, M Azzouz, ...
Scientific reports 5 (1), 12621, 2015
542015
Key aspects of neurovascular control mediated by specific populations of inhibitory cortical interneurons
L Lee, L Boorman, E Glendenning, C Christmas, P Sharp, P Redgrave, ...
Cerebral Cortex 30 (4), 2452-2464, 2020
532020
Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle
M Brockington, S Torelli, PS Sharp, K Liu, S Cirak, SC Brown, DJ Wells, ...
PLoS One 5 (12), e14434, 2010
452010
Site specific modification of adeno-associated virus enables both fluorescent imaging of viral particles and characterization of the capsid interactome
JS Chandran, PS Sharp, E Karyka, JMC Aves-Cruzeiro, I Coldicott, ...
Scientific reports 7 (1), 14766, 2017
332017
A novel automated rodent tracker (ART), demonstrated in a mouse model of amyotrophic lateral sclerosis
BM Hewitt, MH Yap, EF Hodson-Tole, AJ Kennerley, PS Sharp, RA Grant
Journal of neuroscience methods 300, 147-156, 2018
312018
The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer’s disease
KE Ameen-Ali, JE Simpson, SB Wharton, PR Heath, PS Sharp, G Brezzo, ...
Journal of Alzheimer's Disease 68 (2), 609-624, 2019
302019
Abnormalities in whisking behaviour are associated with lesions in brain stem nuclei in a mouse model of amyotrophic lateral sclerosis
RA Grant, PS Sharp, AJ Kennerley, J Berwick, A Grierson, T Ramesh, ...
Behavioural brain research 259, 274-283, 2014
272014
Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model
I de Lázaro, P Sharp, C Gurcan, A Ceylan, M Stylianou, T Kisby, Y Chen, ...
Advanced Therapeutics 4 (1), 2000109, 2021
212021
Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical
PS Sharp, KE Ameen-Ali, L Boorman, S Harris, S Wharton, C Howarth, ...
Journal of Cerebral Blood Flow & Metabolism 40 (11), 2289-2303, 2020
212020
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
Artículos 1–20