Alexander Breeze
Alexander Breeze
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Isotope-filtered NMR methods for the study of biomolecular structure and interactions
AL Breeze
Progress in nuclear magnetic resonance spectroscopy 36 (4), 323-372, 2000
Fragment screening to predict druggability (ligandability) and lead discovery success
FNB Edfeldt, RHA Folmer, AL Breeze
Drug discovery today 16 (7-8), 284-287, 2011
Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase
GW Booker, AL Breeze, AK Downing, G Panayotou, I Gout, MD Waterfield, ...
Nature 358 (6388), 684-687, 1992
The high‐resolution crystal structure of a 24‐kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin
FTF Tsai, OMP Singh, T Skarzynski, AJ Wonacott, S Weston, A Tucker, ...
Proteins: Structure, Function, and Bioinformatics 28 (1), 41-52, 1997
Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation
RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ...
Journal of medicinal chemistry 55 (7), 3285-3306, 2012
Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.
JO Dolly, JV Halliwell, JD Black, RS Williams, A Pelchen-Matthews, ...
Journal de physiologie 79 (4), 280-303, 1984
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes
JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ...
Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007
Small molecule binding sites on the Ras: SOS complex can be exploited for inhibition of Ras activation
JJG Winter, M Anderson, K Blades, C Brassington, AL Breeze, C Chresta, ...
Journal of medicinal chemistry 58 (5), 2265-2274, 2015
Solution structure of human calcitonin gene-related peptide by proton NMR and distance geometry with restrained molecular dynamics
AL Breeze, TS Harvey, R Bazzo, ID Campbell
Biochemistry 30 (2), 575-582, 1991
Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use
H Patani, TD Bunney, N Thiyagarajan, RA Norman, D Ogg, J Breed, ...
Oncotarget 7 (17), 24252, 2016
Prevention of MKK6-dependent activation by binding to p38α MAP kinase
JE Sullivan, GA Holdgate, D Campbell, D Timms, S Gerhardt, J Breed, ...
Biochemistry 44 (50), 16475-16490, 2005
Structure-based design of protein tyrosine phosphatase-1B inhibitors
E Black, J Breed, AL Breeze, K Embrey, R Garcia, TW Gero, L Godfrey, ...
Bioorganic & medicinal chemistry letters 15 (10), 2503-2507, 2005
Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4
JA Tucker, T Klein, J Breed, AL Breeze, R Overman, C Phillips, ...
Structure 22 (12), 1764-1774, 2014
Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain
AR Black, AL Breeze, IB Othman, JO Dolly
Biochemical Journal 237 (2), 397-404, 1986
Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting
B Farrell, AL Breeze
Biochemical Society Transactions 46 (6), 1753-1770, 2018
Three-Dimensional Solution Structure and 13C Nuclear Magnetic Resonance Assignments of the Colicin E9 Immunity Protein Im9,
MJ Osborne, AL Breeze, LY Lian, A Reilly, R James, C Kleanthous, ...
Biochemistry 35 (29), 9505-9512, 1996
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase
T Klein, N Vajpai, JJ Phillips, G Davies, GA Holdgate, C Phillips, ...
Nature communications 6 (1), 7877, 2015
Small‐Molecule Proteomimetic Inhibitors of the HIF‐1α–p300 Protein–Protein Interaction
GM Burslem, HF Kyle, AL Breeze, TA Edwards, A Nelson, SL Warriner, ...
ChemBioChem 15 (8), 1083-1087, 2014
Real‐Time Monitoring of New Delhi Metallo‐β‐Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy
J Ma, S McLeod, K MacCormack, S Sriram, N Gao, AL Breeze, J Hu
Angewandte Chemie International Edition 53 (8), 2130-2133, 2014
Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3‐kinase.
AL Breeze, BV Kara, DG Barratt, M Anderson, JC Smith, RW Luke, ...
The EMBO Journal 15 (14), 3579-3589, 1996
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