| Fragment screening to predict druggability (ligandability) and lead discovery success FNB Edfeldt, RHA Folmer, AL Breeze Drug discovery today 16 (7-8), 284-287, 2011 | 239 | 2011 |
| Isotope-filtered NMR methods for the study of biomolecular structure and interactions AL Breeze Progress in nuclear magnetic resonance spectroscopy 36 (4), 323-372, 2000 | 239 | 2000 |
| Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase GW Booker, AL Breeze, AK Downing, G Panayotou, I Gout, MD Waterfield, ... Nature 358 (6388), 684-687, 1992 | 213 | 1992 |
| The high‐resolution crystal structure of a 24‐kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin FTF Tsai, OMP Singh, T Skarzynski, AJ Wonacott, S Weston, A Tucker, ... Proteins: Structure, Function, and Bioinformatics 28 (1), 41-52, 1997 | 192 | 1997 |
| Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ... Journal of medicinal chemistry 55 (7), 3285-3306, 2012 | 184 | 2012 |
| Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release. JO Dolly, JV Halliwell, JD Black, RS Williams, A Pelchen-Matthews, ... Journal de physiologie 79 (4), 280-303, 1984 | 159 | 1984 |
| An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ... Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007 | 149 | 2007 |
| Small molecule binding sites on the Ras: SOS complex can be exploited for inhibition of Ras activation JJG Winter, M Anderson, K Blades, C Brassington, AL Breeze, C Chresta, ... Journal of medicinal chemistry 58 (5), 2265-2274, 2015 | 135 | 2015 |
| Solution structure of human calcitonin gene-related peptide by proton NMR and distance geometry with restrained molecular dynamics AL Breeze, TS Harvey, R Bazzo, ID Campbell Biochemistry 30 (2), 575-582, 1991 | 126 | 1991 |
| Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use H Patani, TD Bunney, N Thiyagarajan, RA Norman, D Ogg, J Breed, ... Oncotarget 7 (17), 24252, 2016 | 114 | 2016 |
| Prevention of MKK6-dependent activation by binding to p38α MAP kinase JE Sullivan, GA Holdgate, D Campbell, D Timms, S Gerhardt, J Breed, ... Biochemistry 44 (50), 16475-16490, 2005 | 110 | 2005 |
| Structure-based design of protein tyrosine phosphatase-1B inhibitors E Black, J Breed, AL Breeze, K Embrey, R Garcia, TW Gero, L Godfrey, ... Bioorganic & medicinal chemistry letters 15 (10), 2503-2507, 2005 | 110 | 2005 |
| Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4 JA Tucker, T Klein, J Breed, AL Breeze, R Overman, C Phillips, ... Structure 22 (12), 1764-1774, 2014 | 108 | 2014 |
| Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting B Farrell, AL Breeze Biochemical Society Transactions 46 (6), 1753-1770, 2018 | 91 | 2018 |
| Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain AR Black, AL Breeze, IB Othman, JO Dolly Biochemical Journal 237 (2), 397-404, 1986 | 84 | 1986 |
| Small‐Molecule Proteomimetic Inhibitors of the HIF‐1α–p300 Protein–Protein Interaction GM Burslem, HF Kyle, AL Breeze, TA Edwards, A Nelson, SL Warriner, ... ChemBioChem 15 (8), 1083-1087, 2014 | 76 | 2014 |
| Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase T Klein, N Vajpai, JJ Phillips, G Davies, GA Holdgate, C Phillips, ... Nature communications 6 (1), 7877, 2015 | 75 | 2015 |
| Real‐Time Monitoring of New Delhi Metallo‐β‐Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy J Ma, S McLeod, K MacCormack, S Sriram, N Gao, AL Breeze, J Hu Angewandte Chemie International Edition 53 (8), 2130-2133, 2014 | 74 | 2014 |
| Three-Dimensional Solution Structure and 13C Nuclear Magnetic Resonance Assignments of the Colicin E9 Immunity Protein Im9, MJ Osborne, AL Breeze, LY Lian, A Reilly, R James, C Kleanthous, ... Biochemistry 35 (29), 9505-9512, 1996 | 73 | 1996 |
| Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3‐kinase. AL Breeze, BV Kara, DG Barratt, M Anderson, JC Smith, RW Luke, ... The EMBO Journal 15 (14), 3579-3589, 1996 | 56 | 1996 |
