Persistent epigenetic differences associated with prenatal exposure to famine in humans BT Heijmans, EW Tobi, AD Stein, H Putter, GJ Blauw, ES Susser, ... Proceedings of the National Academy of Sciences 105 (44), 17046-17049, 2008 | 3562 | 2008 |
DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific EW Tobi, LH Lumey, RP Talens, D Kremer, H Putter, AD Stein, ... Human molecular genetics 18 (21), 4046-4053, 2009 | 1316 | 2009 |
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... Nature genetics 53 (9), 1300-1310, 2021 | 1193* | 2021 |
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze, PC Tsai, JS Ried, ... Nature 541 (7635), 81-86, 2017 | 851 | 2017 |
DNA methylation aging clocks: challenges and recommendations CG Bell, R Lowe, PD Adams, AA Baccarelli, S Beck, JT Bell, ... Genome biology 20, 1-24, 2019 | 681 | 2019 |
DNA methylation signatures link prenatal famine exposure to growth and metabolism EW Tobi, JJ Goeman, R Monajemi, H Gu, H Putter, Y Zhang, RC Slieker, ... Nature communications 5 (1), 5592, 2014 | 601 | 2014 |
Periconceptional maternal folic acid use of 400 µg per day is related to increased methylation of the IGF2 gene in the very young child RP Steegers-Theunissen, SA Obermann-Borst, D Kremer, J Lindemans, ... PloS one 4 (11), e7845, 2009 | 553 | 2009 |
Disease variants alter transcription factor levels and methylation of their binding sites MJ Bonder, R Luijk, D Zhernakova, M Moed, P Deelen, M Vermaat, ... Nature genetics 49 (1), 131–138, 2017 | 451 | 2017 |
Identification of context-dependent expression quantitative trait loci in whole blood DV Zhernakova, P Deelen, M Vermaat, M Van Iterson, M Van Galen, ... Nature genetics 49 (1), 139-145, 2017 | 444 | 2017 |
From promises to practical strategies in epigenetic epidemiology J Mill, BT Heijmans Nature Reviews Genetics 14 (8), 585-594, 2013 | 388 | 2013 |
Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs RP Talens, K Christensen, H Putter, G Willemsen, L Christiansen, ... Aging cell 11 (4), 694-703, 2012 | 377 | 2012 |
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology RP Talens, DI Boomsma, EW Tobi, D Kremer, JW Jukema, G Willemsen, ... The FASEB Journal 24 (9), 3135-3144, 2010 | 368 | 2010 |
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation N Kato, M Loh, F Takeuchi, N Verweij, X Wang, W Zhang, TN Kelly, ... Nature genetics 47 (11), 1282-1293, 2015 | 357 | 2015 |
Reduced insulin/IGF‐1 signalling and human longevity D Van Heemst, M Beekman, SP Mooijaart, BT Heijmans, BW Brandt, ... Aging cell 4 (2), 79-85, 2005 | 356 | 2005 |
Genetic and environmental influences interact with age and sex in shaping the human methylome J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ... Nature communications 7 (1), 11115, 2016 | 353 | 2016 |
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ... Aging cell 10 (4), 686-698, 2011 | 319 | 2011 |
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study RGJ Westendorp, D Van Heemst, MP Rozing, M Frölich, SP Mooijaart, ... Journal of the American Geriatrics Society 57 (9), 1634-1637, 2009 | 305 | 2009 |
The epigenome: archive of the prenatal environment BT Heijmans, EW Tobi, LH Lumey, PE Slagboom Epigenetics 4 (8), 526-531, 2009 | 302 | 2009 |
Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution M van Iterson, EW van Zwet, Bios Consortium, BT Heijmans Genome biology 18, 1-13, 2017 | 298 | 2017 |
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes JAM Wessels, JK de Vries‐Bouwstra, BT Heijmans, PE Slagboom, ... Arthritis & Rheumatism 54 (4), 1087-1095, 2006 | 296 | 2006 |