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Frank Otto Gombert
Frank Otto Gombert
GPRS Gombert Pharma Research Solutions, Selmod GmbH/LLC, CH 4053 Basel, Switzerland
Correu electrònic verificat a gpr-solutions.ch - Pàgina d'inici
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Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa
N Srinivas, P Jetter, BJ Ueberbacher, M Werneburg, K Zerbe, ...
Science 327 (5968), 1010-1013, 2010
5802010
The design, structures and therapeutic potential of protein epitope mimetics
JA Robinson, S DeMarco, F Gombert, K Moehle, D Obrecht
Drug discovery today 13 (21-22), 944-951, 2008
1522008
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
SJ DeMarco, H Henze, A Lederer, K Moehle, R Mukherjee, B Romagnoli, ...
Bioorganic & medicinal chemistry 14 (24), 8396-8404, 2006
1072006
Rapid identification of phosphopeptide ligands for SH2 domains
K Müller, FO Gombert, U Manning, F Grossmüller, P Graff, H Zaegel, ...
J BioI Chern 271 (271), 16500-16505, 1996
96*1996
Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3
M Wiederkehr-Adam, P Ernst, K Müller, E Bieck, FO Gombert, J Ottl, ...
Journal of Biological Chemistry 278 (18), 16117-16128, 2003
772003
Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies
V Ovod, A Lagerstedt, A Ranki, FO Gombert, R Spohnt, M Tähtinen, ...
Aids 6 (1), 25-34, 1992
661992
Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics
D Obrecht, JA Robinson, F Bernardini, C Bisang, SJ DeMarco, K Moehle, ...
Current medicinal chemistry 16 (1), 42-65, 2009
572009
Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026
G Moncunill, M Armand-Ugon, I Clotet-Codina, E Pauls, E Ballana, ...
Molecular Pharmacology 73 (4), 1264-1273, 2008
552008
Antigenic epitopes of NEF proteins from different HIV-1 strains as recognized by sera from patients with manifest and latent HIV infection
FO Gombert, W Blecha, M Tähtinen, A Ranki, S Pfeifer, W Tröger, R Braun, ...
Virology 176 (2), 458-466, 1990
471990
Characterization of human monoclonal antibodies directed against the pp65-kD matrix antigen of human cytomegalovirus.
M Ohlin, VA Sundqvist, G Gilljam, U Ruden, FO Gombert, B Wahren, ...
Clinical and experimental immunology 84 (3), 508, 1991
421991
Template fixed beta-hairpin loop mimetics and their use in phage display
JW Vrijbloed, D Obrecht, S Locurio, FO Gombert, C Ludin, F Jung
US Patent 7,994,118, 2011
252011
Template-fixed peptidomimetics with CXCR7 modulating activity
FO Gombert, A Lederer, D Obrecht, B Romagnoli, C Bisang, C Ludin
US Patent 8,629,112, 2014
222014
Template-fixed δ-hairpin peptidomimetics with CXCR4 antagonizing activity
J Zumbrunn, SJ DeMarco, S Lociuro, JW Vrijbloed, F Gombert, ...
US Patent 7,786,078, 2010
21*2010
Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
SJ DeMarco, K Moehle, H Henze, O Sellier, F Jung, F Gombert, D Obrecht, ...
US Patent 8,658,604, 2014
192014
Synthetic peptide segments from the Escherichia coli porin OmpF constitute leukocyte activators
HM Vordermeier, P Hoffmann, FO Gombert, G Jung, WG Bessler
Infection and immunity 58 (8), 2719-2724, 1990
191990
Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
D Obrecht, F Gombert, A Lederer, B Romagnoli, C Bisang
US Patent 8,865,656, 2014
16*2014
Template-fixed peptidomimetics with antimicrobial activity
JW Vrijbloed, D Obrecht, JA Robinson, S Locurio, F Gombert, C Ludin, ...
US Patent 7,855,179, 2010
162010
Alanine and D-amino acid scan of human parathyroid hormone
FO Gombert, R Gamse, JHM Feyen, F Cardinaux
PEPTIDES-AMERICAN SYMPOSIUM- 14, 661-662, 1996
161996
Template fixed beta-hairpin loop mimetics and their use in phage display
JW Vrijbloed, D Obrecht, S Locurio, FO Gombert, C Ludin, F Jung
US Patent 8,796,183, 2014
152014
Template-fixed peptidomimetics as medicaments against HIV and cancer
J Zumbrunn, SJ DeMarco, S Lociuro, JW Vrijbloed, F Gombert, ...
US Patent 7,838,496, 2010
152010
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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