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Hugh Welles
Hugh Welles
Director of synthetic immunotherapy development
Dirección de correo verificada de barinthusbio.com
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Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human …
KC Conlon, E Lugli, HC Welles, SA Rosenberg, AT Fojo, JC Morris, ...
Journal of clinical oncology 33 (1), 74-82, 2015
6962015
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
M Roederer, BF Keele, SD Schmidt, RD Mason, HC Welles, W Fischer, ...
Nature 505 (7484), 502-508, 2014
1532014
Immune-complexed adenovirus induce AIM2-mediated pyroptosis in human dendritic cells
K Eichholz, T Bru, TTP Tran, P Fernandes, H Welles, FJD Mennechet, ...
PLoS pathogens 12 (9), e1005871, 2016
742016
Lack of Mycobacterium tuberculosis–specific interleukin‐17A–producing CD4+ T cells in active disease
M Perreau, V Rozot, HC Welles, F Belluti‐Enders, S Vigano, M Maillard, ...
European journal of immunology 43 (4), 939-948, 2013
732013
Targeted isolation of antibodies directed against major sites of SIV Env vulnerability
RD Mason, HC Welles, C Adams, BK Chakrabarti, J Gorman, T Zhou, ...
PLoS Pathogens 12 (4), e1005537, 2016
612016
DNA/NYVAC vaccine regimen induces HIV-specific CD4 and CD8 T-cell responses in intestinal mucosa
M Perreau, HC Welles, A Harari, O Hall, R Martin, M Maillard, G Dorta, ...
Journal of virology 85 (19), 9854-9862, 2011
612011
Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge
HC Welles, MF Jennewein, RD Mason, S Narpala, L Wang, C Cheng, ...
PLoS pathogens 14 (12), e1007395, 2018
442018
Blocking α4β7 integrin binding to SIV does not improve virologic control
N Iwamoto, RD Mason, K Song, J Gorman, HC Welles, J Arthos, C Cicala, ...
Science 365 (6457), 1033-1036, 2019
312019
The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces
I Vujkovic-Cvijin, HC Welles, CWY Ha, L Huq, S Mistry, JM Brenchley, ...
Science translational medicine 14 (658), eabl3927, 2022
282022
The number of Toll-like receptor 9-agonist motifs in the adenovirus genome correlates with induction of dendritic cell maturation by adenovirus immune complexes
M Perreau, HC Welles, C Pellaton, B Gjoksi, L Potin, R Martin, A Harari, ...
Journal of virology 86 (11), 6279-6285, 2012
282012
Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous simian immunodeficiency virus vaccine challenge study
FH Lee, R Mason, H Welles, GH Learn, BF Keele, M Roederer, KJ Bar
Journal of Virology 89 (24), 12388-12400, 2015
112015
Cryo-EM structures of prefusion SIV envelope trimer
J Gorman, C Wang, RD Mason, AF Nazzari, HC Welles, T Zhou, ...
Nature structural & molecular biology 29 (11), 1080-1091, 2022
82022
Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4
HC Welles, HAD King, L Nettey, N Cavett, J Gorman, T Zhou, Y Tsybovsky, ...
PLoS Pathogens 18 (6), e1010574, 2022
62022
Modulation of human memory T‐cell function by different antigen‐presenting cells
M Perreau, HC Welles, A Harari, T Calandra, T Roger, G Pantaleo
European journal of immunology 42 (3), 799-802, 2012
42012
A high throughput lentivirus sieving assay identifies neutralization resistant Envelope sequences and predicts in vivo sieving
N Iwamoto, R Mason, J Hu, A Ransier, H Welles, K Song, D Douek, ...
Journal of immunological methods 464, 64-73, 2019
22019
The Number of TLR9-Agonist Motifs in the Adenovirus Genome Correlates with Induction of DC Maturation by Adenovirus Immune Complexes
M Perreau, HC Welles, C Pellaton, B Gjoksi, L Potin, R Martin
J Virol 86 (11), 6279-85, 2012
22012
Correction: Targeted isolation of antibodies directed against major sites of SIV Env vulnerability
RD Mason, HC Welles, C Adams, BK Chakrabarti, J Gorman, T Zhou, ...
Plos Pathogens 12 (5), e1005674, 2016
12016
Results from the first-in-human phase I trials of recombinant human Interleukin 15 (rhIL-15) administered as a daily 30 minute intravenous infusion (IVB) for 12 consecutive …
KC Conlon, E Lugli, SA Rosenberg, JC Morris, T Fleisher, H Welles, ...
Cancer research 74 (19_Supplement), 2575-2575, 2014
12014
Mo1597: SYSTEMIC ANTI-MICROBIOTA IMMUNOGLOBULIN G AS A BIOMARKER TO IDENTIFY TRANSLOCATING, PRO-INFLAMMATORY GUT BACTERIA IN IBD
I Vujkovic-Cvijin, H Welles, CW Ha, L Huq, S Mistry, J Brenchley, ...
Gastroenterology 162 (7), S-832, 2022
2022
Systemic IgG repertoire as a biomarker for translocating gut microbiota members
I Vujkovic-Cvijin, H Welles, CWY Ha, L Huq, S Mistry, JM Brenchley, ...
bioRxiv, 2021.08. 17.456549, 2021
2021
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Artículos 1–20