ivan topisirovic
ivan topisirovic
Professor, McGill, Lady Davis Institute
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
MJA DJ Klionsky, K Abdelmohsen, A Abe
Autophagy 12 (1), 2016
Targeting the translation machinery in cancer
M Bhat, N Robichaud, L Hulea, N Sonenberg, J Pelletier, I Topisirovic
Nature reviews Drug discovery 14 (4), 261-278, 2015
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ...
Science 328 (5982), 1172-1176, 2010
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
M Morita, SP Gravel, V Chenard, K Sikström, L Zheng, T Alain, V Gandin, ...
Cell metabolism 18 (5), 698-711, 2013
Dissecting the role of mTOR: lessons from mTOR inhibitors
RJO Dowling, I Topisirovic, BD Fonseca, N Sonenberg
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 433-439, 2010
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
M Morita, SP Gravel, L Hulea, O Larsson, M Pollak, J St-Pierre, ...
Cell cycle 14 (4), 473-480, 2015
Cap and cap‐binding proteins in the control of gene expression
I Topisirovic, YV Svitkin, N Sonenberg, AJ Shatkin
Wiley Interdisciplinary Reviews: RNA 2 (2), 277-298, 2011
eIF4E is a central node of an RNA regulon that governs cellular proliferation
B Culjkovic, I Topisirovic, L Skrabanek, M Ruiz-Gutierrez, KLB Borden
The Journal of cell biology 175 (3), 415-426, 2006
mTOR as a central regulator of lifespan and aging
D Papadopoli, K Boulay, L Kazak, M Pollak, FA Mallette, I Topisirovic, ...
F1000Research 8, 2019
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap
A Kentsis, I Topisirovic, B Culjkovic, L Shao, KLB Borden
Proceedings of the National Academy of Sciences 101 (52), 18105-18110, 2004
Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities
I Topisirovic, M Ruiz-Gutierrez, KLB Borden
Cancer research 64 (23), 8639-8642, 2004
mTOR controls mitochondrial dynamics and cell survival via MTFP1
M Morita, J Prudent, K Basu, V Goyon, S Katsumura, L Hulea, D Pearl, ...
Molecular cell 67 (6), 922-935. e5, 2017
Signaling pathways involved in the regulation of mRNA translation
PP Roux, I Topisirovic
Molecular and cellular biology, 2018
Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis
I Topisirovic, ML Guzman, MJ McConnell, JD Licht, B Culjkovic, ...
Molecular and cellular biology, 2003
Regulation of mRNA translation by signaling pathways
PP Roux, I Topisirovic
Cold Spring Harbor perspectives in biology 4 (11), a012252, 2012
eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′ UTR
B Culjkovic, I Topisirovic, L Skrabanek, M Ruiz-Gutierrez, KLB Borden
The Journal of cell biology 169 (2), 245-256, 2005
Translational control of immune responses: from transcripts to translatomes
CA Piccirillo, E Bjur, I Topisirovic, N Sonenberg, O Larsson
Nature immunology 15 (6), 503-511, 2014
S6K1 plays a critical role in early adipocyte differentiation
LS Carnevalli, K Masuda, F Frigerio, O Le Bacquer, SH Um, V Gandin, ...
Developmental cell 18 (5), 763-774, 2010
nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs
V Gandin, L Masvidal, L Hulea, SP Gravel, M Cargnello, S McLaughlan, ...
Genome research 26 (5), 636-648, 2016
Distinct perturbation of the translatome by the antidiabetic drug metformin
O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ...
Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012
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