|FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation|
JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao, J Ruan, X Luo, X Lou, ...
Nature immunology 21 (7), 736-745, 2020
|DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation|
LR Hollingsworth, H Sharif, AR Griswold, P Fontana, J Mintseris, ...
Nature 592 (7856), 778-783, 2021
|Mechanism and regulation of gasdermin-mediated cell death|
S Xia, LR Hollingsworth, H Wu
Cold Spring Harbor Perspectives in Biology 12 (3), a036400, 2020
|Bromodomain inhibitors correct bioenergetic deficiency caused by mitochondrial disease complex I mutations|
JJ Barrow, E Balsa, F Verdeguer, CDJ Tavares, MS Soustek, ...
Molecular cell 64 (1), 163-175, 2016
|Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes|
LR Hollingsworth, L David, Y Li, AR Griswold, J Ruan, H Sharif, P Fontana, ...
Nature Communications 12 (1), 1-13, 2021
|Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment|
H Sharif, LR Hollingsworth, AR Griswold, JC Hsiao, Q Wang, ...
Immunity 54 (7), 1392-1404. e10, 2021
|HIV-1 env gp41 transmembrane domain dynamics are modulated by lipid, water, and ion interactions|
LR Hollingsworth, JA Lemkul, DR Bevan, AM Brown
Biophysical journal 115 (1), 84-94, 2018
|Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region|
LR Hollingsworth IV, AM Brown, RD Gandour, DR Bevan
Plos one 13 (1), e0190658, 2018
|Molecular evolution of genes encoding allergen proteins in the peanuts genus Arachis: Structural and functional implications|
KW Hilu, SA Friend, V Vallanadu, AM Brown, LR Hollingsworth IV, ...
Plos one 14 (11), e0222440, 2019
|Molecular mechanisms for the regulation and assembly of the NLRP1 and CARD8 inflammasomes|
Harvard University, 2022
|Purification of the NLRP1-DPP9 Complex from Expi293F Cells|
|Speak out against tuition waiver taxes|
LR Hollingsworth IV, P Veeraraghavan, KJ Wu, DE McCoy, A Van Dervort, ...
Science 358 (6369), 1395-1395, 2017
|Utilizing Computational Techniques to Accelerate Discovery in Peanut Allergenicity: A Case Study|
LR Hollingsworth IV, AM Brown, DR Bevan
Proceedings of the Practice and Experience in Advanced Research Computing …, 2017