FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao, J Ruan, X Luo, X Lou, ... Nature immunology 21 (7), 736-745, 2020 | 424 | 2020 |
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation LR Hollingsworth, H Sharif, AR Griswold, P Fontana, J Mintseris, ... Nature 592 (7856), 778-783, 2021 | 88 | 2021 |
Mechanism and regulation of gasdermin-mediated cell death S Xia, LR Hollingsworth, H Wu Cold Spring Harbor Perspectives in Biology 12 (3), a036400, 2020 | 83 | 2020 |
Bromodomain inhibitors correct bioenergetic deficiency caused by mitochondrial disease complex I mutations JJ Barrow, E Balsa, F Verdeguer, CDJ Tavares, MS Soustek, ... Molecular cell 64 (1), 163-175, 2016 | 52 | 2016 |
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes LR Hollingsworth, L David, Y Li, AR Griswold, J Ruan, H Sharif, P Fontana, ... Nature Communications 12 (1), 1-13, 2021 | 44* | 2021 |
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment H Sharif, LR Hollingsworth, AR Griswold, JC Hsiao, Q Wang, ... Immunity 54 (7), 1392-1404. e10, 2021 | 35 | 2021 |
HIV-1 env gp41 transmembrane domain dynamics are modulated by lipid, water, and ion interactions LR Hollingsworth, JA Lemkul, DR Bevan, AM Brown Biophysical journal 115 (1), 84-94, 2018 | 14 | 2018 |
Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region LR Hollingsworth IV, AM Brown, RD Gandour, DR Bevan Plos one 13 (1), e0190658, 2018 | 6 | 2018 |
Molecular evolution of genes encoding allergen proteins in the peanuts genus Arachis: Structural and functional implications KW Hilu, SA Friend, V Vallanadu, AM Brown, LR Hollingsworth IV, ... Plos one 14 (11), e0222440, 2019 | 2 | 2019 |
Molecular mechanisms for the regulation and assembly of the NLRP1 and CARD8 inflammasomes LR Hollingsworth Harvard University, 2022 | | 2022 |
Purification of the NLRP1-DPP9 Complex from Expi293F Cells LR Hollingsworth | | 2021 |
Speak out against tuition waiver taxes LR Hollingsworth IV, P Veeraraghavan, KJ Wu, DE McCoy, A Van Dervort, ... Science 358 (6369), 1395-1395, 2017 | | 2017 |
Utilizing Computational Techniques to Accelerate Discovery in Peanut Allergenicity: A Case Study LR Hollingsworth IV, AM Brown, DR Bevan Proceedings of the Practice and Experience in Advanced Research Computing …, 2017 | | 2017 |