Clary Clish
Clary Clish
Senior Director, Metabolomics, Broad Institute of MIT and Harvard
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Metabolite profiles and the risk of developing diabetes
TJ Wang, MG Larson, RS Vasan, S Cheng, EP Rhee, E McCabe, ...
Nature medicine 17 (4), 448-453, 2011
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, ...
Nature 496 (7444), 238-242, 2013
Regulation of ferroptotic cancer cell death by GPX4
WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ...
Cell 156 (1-2), 317-331, 2014
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
K Düvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, ...
Molecular cell 39 (2), 171-183, 2010
Lipid mediator class switching during acute inflammation: signals in resolution
BD Levy, CB Clish, B Schmidt, K Gronert, CN Serhan
Nature immunology 2 (7), 612-619, 2001
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2–nonsteroidal antiinflammatory drugs and …
CN Serhan, CB Clish, J Brannon, SP Colgan, N Chiang, K Gronert
The Journal of experimental medicine 192 (8), 1197-1204, 2000
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
M Jain, R Nilsson, S Sharma, N Madhusudhan, T Kitami, AL Souza, ...
Science 336 (6084), 1040-1044, 2012
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α
L Zhong, A D'Urso, D Toiber, C Sebastian, RE Henry, DD Vadysirisack, ...
Cell 140 (2), 280-293, 2010
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
J Lloyd-Price, C Arze, AN Ananthakrishnan, M Schirmer, J Avila-Pacheco, ...
Nature 569 (7758), 655-662, 2019
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes
AD Kostic, D Gevers, H Siljander, T Vatanen, T Hyötyläinen, ...
Cell host & microbe 17 (2), 260-273, 2015
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization
LWS Finley, A Carracedo, J Lee, A Souza, A Egia, J Zhang, ...
Cancer cell 19 (3), 416-428, 2011
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
EM Palsson-McDermott, AM Curtis, G Goel, MAR Lauterbach, FJ Sheedy, ...
Cell metabolism 21 (1), 65-80, 2015
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
V Rothhammer, ID Mascanfroni, L Bunse, MC Takenaka, JE Kenison, ...
Nature medicine 22 (6), 586-597, 2016
Gut microbiome structure and metabolic activity in inflammatory bowel disease
EA Franzosa, A Sirota-Madi, J Avila-Pacheco, N Fornelos, HJ Haiser, ...
Nature microbiology 4 (2), 293-305, 2019
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
K Birsoy, R Possemato, FK Lorbeer, EC Bayraktar, P Thiru, B Yucel, ...
Nature 508 (7494), 108-112, 2014
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress
F Vazquez, JH Lim, H Chim, K Bhalla, G Girnun, K Pierce, CB Clish, ...
Cancer cell 23 (3), 287-301, 2013
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
SM Davidson, T Papagiannakopoulos, BA Olenchock, JE Heyman, ...
Cell metabolism 23 (3), 517-528, 2016
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
EP Rhee, S Cheng, MG Larson, GA Walford, GD Lewis, E McCabe, ...
The Journal of clinical investigation 121 (4), 1402-1411, 2011
Targeted metabolomics
LD Roberts, AL Souza, RE Gerszten, CB Clish
Current protocols in molecular biology 98 (1), 30.2. 1-30.2. 24, 2012
Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis
M Guasch-Ferré, A Hruby, E Toledo, CB Clish, MA Martínez-González, ...
Diabetes care 39 (5), 833-846, 2016
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Artículos 1–20