Cintia Roodveldt
Cintia Roodveldt
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The'evolvability'of promiscuous protein functions
A Aharoni, L Gaidukov, O Khersonsky, SMQ Gould, C Roodveldt, ...
Nature genetics 37 (1), 73-76, 2005
Enzyme promiscuity: evolutionary and mechanistic aspects
O Khersonsky, C Roodveldt, DS Tawfik
Current opinion in chemical biology 10 (5), 498-508, 2006
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
The latent promiscuity of newly identified microbial lactonases is linked to a recently diverged phosphotriesterase
L Afriat, C Roodveldt, G Manco, DS Tawfik
Biochemistry 45 (46), 13677-13686, 2006
High‐throughput Screens and Selections of Enzyme‐encoding Genes
A Aharoni, C Roodveldt, AD Griffiths, DS Tawfik
Enzyme Assays: High‐throughput Screening, Genetic Selection and Fingerprinting, 2005
Directed evolution of proteins for heterologous expression and stability
C Roodveldt, A Aharoni, DS Tawfik
Current opinion in structural biology 15 (1), 50-56, 2005
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, ...
Proceedings of the National Academy of Sciences 109 (31), 12479-12484, 2012
Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily
C Roodveldt, DS Tawfik
Biochemistry 44 (38), 12728-12736, 2005
Chaperone proteostasis in Parkinson's disease: Stabilization of the Hsp70/α‐synuclein complex by Hip
C Roodveldt, CW Bertoncini, A Andersson, AT Van Der Goot, ST Hsu, ...
The EMBO journal 28 (23), 3758-3770, 2009
Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state
C Roodveldt, DS Tawfik
Protein Engineering Design and Selection 18 (1), 51-58, 2005
Immunological features of α‐synuclein in Parkinson's disease
C Roodveldt, J Christodoulou, CM Dobson
Journal of cellular and molecular medicine 12 (5b), 1820-1829, 2008
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants
C Roodveldt, A Labrador-Garrido, E Gonzalez-Rey, ...
PloS one 5 (10), e13481, 2010
Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation
C Roodveldt, A Labrador-Garrido, E Gonzalez-Rey, CC Lachaud, ...
PloS one 8 (11), e79160, 2013
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, ...
PLoS One 8 (6), e67961, 2013
The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction
B Sot, A Rubio-Muñoz, A Leal-Quintero, J Martínez-Sabando, M Marcilla, ...
Scientific reports 7 (1), 40859, 2017
The ‘omics’ of amyotrophic lateral sclerosis
D Caballero-Hernandez, MG Toscano, M Cejudo-Guillen, ...
Trends in molecular medicine 22 (1), 53-67, 2016
Extracellular TDP‐43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase‐3/IL‐18 signaling in microglia
MM Leal‐Lasarte, JM Franco, A Labrador‐Garrido, D Pozo, C Roodveldt
The FASEB Journal 31 (7), 2797-2816, 2017
A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein
C Roodveldt, A Andersson, EJ De Genst, A Labrador-Garrido, AK Buell, ...
Biochemistry 51 (44), 8771-8778, 2012
Trypanosoma cruzi: identification of a galactose-binding protein that binds to cell surface of human erythrocytes and is involved in cell invasion by the parasite
AM Silber, IS Marcipar, C Roodveldt, PC Meckert, R Laguens, ...
Experimental parasitology 100 (4), 217-225, 2002
Immunization with α‐synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model
J Villadiego, A Labrador‐Garrido, JM Franco, M Leal‐Lasarte, ...
Glia 66 (1), 191-205, 2018
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