Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics Y Sun, SY Lau, ZW Lim, SC Chang, F Ghadessy, A Partridge, A Miserez Nature Chemistry 14 (3), 274-283, 2022 | 137 | 2022 |
Kv1. 3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases S Chhabra, SC Chang, HM Nguyen, R Huq, MR Tanner, LM Londono, ... The FASEB Journal 28 (9), 3952, 2014 | 88 | 2014 |
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA) S Lim, R Khoo, KM Peh, J Teo, SC Chang, S Ng, GL Beilhartz, RA Melnyk, ... Proceedings of the National Academy of Sciences 117 (11), 5791-5800, 2020 | 79 | 2020 |
Development of highly selective Kv1. 3-blocking peptides based on the sea anemone peptide ShK MW Pennington, SC Chang, S Chauhan, R Huq, RB Tajhya, S Chhabra, ... Marine Drugs 13 (1), 529-542, 2015 | 71 | 2015 |
A potent and selective peptide blocker of the Kv1. 3 channel: prediction from free-energy simulations and experimental confirmation MH Rashid, G Heinzelmann, R Huq, RB Tajhya, SC Chang, S Chhabra, ... PloS one 8 (11), e78712, 2013 | 69 | 2013 |
CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice Z Her, JHL Tan, YS Lim, SY Tan, XY Chan, WWS Tan, M Liu, KSM Yong, ... Frontiers in immunology 11, 580968, 2020 | 61 | 2020 |
N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel … SC Chang, R Huq, S Chhabra, C Beeton, MW Pennington, BJ Smith, ... The FEBS journal 282 (12), 2247-2259, 2015 | 38 | 2015 |
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria SC Chang, CA Galea, EWW Leung, RB Tajhya, C Beeton, ... Toxicon 60 (5), 840-850, 2012 | 32 | 2012 |
Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin ST Ong, S Bajaj, MR Tanner, SC Chang, B Krishnarjuna, XR Ng, ... ACS pharmacology & translational science 3 (4), 720-736, 2020 | 19 | 2020 |
Conformational flexibility in the binding surface of the potassium channel blocker ShK I Sher, SC Chang, Y Li, S Chhabra, AG Palmer III, RS Norton, JH Chill ChemBioChem 15 (16), 2402-2410, 2014 | 12 | 2014 |
Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death SC Chang, P Gopal, S Lim, X Wei, A Chandramohan, R Mangadu, ... Cell Chemical Biology 29 (11), 1601-1615. e7, 2022 | 9 | 2022 |
ShK toxin: history, structure and therapeutic applications for autoimmune diseases SC Chang, S Bajaj, KG Chandy WikiJournal of Science 1 (1), 1-13, 2018 | 8 | 2018 |
STUB1 is an intracellular checkpoint for interferon gamma sensing S Ng, S Lim, ACN Sim, R Mangadu, A Lau, C Zhang, SB Martinez, ... Scientific Reports 12 (1), 14087, 2022 | 6 | 2022 |
Kv1. 3-Blocking Peptides from Parasitic Worms Exhibit Immunomodulatory Function HM Nguyen, S Chhabra, SC Chang, RU Huq, MR Tanner, LM Londono, ... Biophysical Journal 106 (2), 739a, 2014 | 2 | 2014 |
Novel potassium channel blockers for the treatment of multiple sclerosis and other autoimmune diseases SC Chang Monash University, 2014 | 1 | 2014 |
Potassium channel blockers and use thereof in the treatment of autoimmune diseases RS Norton, SC Chang, MW Pennington, C Beeton, BJ Smith US Patent 10,246,496, 2019 | | 2019 |
Biophysical and structural characterization of a putative K+ channel from Mycobacterium tuberculosis-a potential drug target S Bajaj, J Ng Jun Heng, KG Chandy, A El Sahili, J Lescar, SC Chang, ... | | 2018 |
Cover Picture: Conformational Flexibility in the Binding Surface of the Potassium Channel Blocker ShK (ChemBioChem 16/2014) I Sher, SC Chang, Y Li, S Chhabra, AG Palmer III, RS Norton, JH Chill ChemBioChem 15 (16), 2317-2317, 2014 | | 2014 |