José Manuel García-Heredia
José Manuel García-Heredia
Instituto de Biomedicina de Sevilla, Universidad de Sevilla
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Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
JM García-Heredia, I Díaz-Moreno, PM Nieto, M Orzáez, S Kocanis, ...
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1797 (6-7), 981-993, 2010
Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch
JM García-Heredia, A Díaz-Quintana, M Salzano, M Orzáez, ...
JBIC Journal of Biological Inorganic Chemistry 16, 1155-1168, 2011
Role of mitochondria in cancer stem cell resistance
JM García-Heredia, A Carnero
Cells 9 (7), 1693, 2020
Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures
JM García-Heredia, M Hervás, MA De la Rosa, JA Navarro
Planta 228, 89-97, 2008
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB
JM Garcia-Heredia, A Lucena-Cacace, EM Verdugo-Sivianes, M Pérez, ...
Clinical Cancer Research 23 (14), 3871-3883, 2017
Decoding Warburg's hypothesis: Tumor-related mutations in the mitochondrial respiratory chain
JM Garcia-Heredia, A Carnero
Oncotarget 6 (39), 41582, 2015
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
JM García-Heredia, EMV Sivianes, A Lucena-Cacace, S Molina-Pinelo, ...
Oncotarget 7 (39), 63611, 2016
Effect of Nitration on the Physicochemical and Kinetic Features of Wild-Type and Monotyrosine Mutants of Human Respiratory Cytochrome c
V Rodríguez-Roldán, JM García-Heredia, JA Navarro, MAD Rosa, ...
Biochemistry 47 (47), 12371-12379, 2008
Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin
I Díaz-Moreno, JM García-Heredia, A Díaz-Quintana, M Teixeira, A Miguel
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1807 (12), 1616-1623, 2011
Perturbation of the Redox Site Structure of Cytochrome c Variants upon Tyrosine Nitration
HK Ly, T Utesch, I Díaz-Moreno, JM Garcia-Heredia, MA De La Rosa, ...
The Journal of Physical Chemistry B 116 (19), 5694-5702, 2012
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
JM García-Heredia, I Díaz-Moreno, A Díaz-Quintana, M Orzáez, ...
FEBS letters 586 (2), 154-158, 2012
Cytochrome c signalosome in mitochondria
I Díaz-Moreno, JM García-Heredia, A Díaz-Quintana, MA De la Rosa
European Biophysics Journal 40, 1301-1315, 2011
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
S Muñoz-Galván, B Felipe-Abrio, M García-Carrasco, J Domínguez-Piñol, ...
Journal of Experimental & Clinical Cancer Research 38, 1-14, 2019
Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance
L Macías-García, M Martínez-Ballesteros, JM Luna-Romera, ...
Artificial Intelligence in Medicine 110, 101976, 2020
A comparative kinetic analysis of the reactivity of plant, horse, and human respiratory cytochrome c towards cytochrome c oxidase
V Rodríguez-Roldán, JM García-Heredia, JA Navarro, M Hervás, ...
Biochemical and biophysical research communications 346 (3), 1108-1113, 2006
Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources
M Martínez-Ballesteros, García-Heredia, J M., IA Nepomuceno-Chamorro, ...
Information Fusion 36, 114-129, 2017
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
JM García-Heredia, A Carnero
Oncotarget 8 (58), 98580, 2017
Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1)
M Perez, J Peinado-Serrano, JM Garcia-Heredia, I Felipe-Abrio, C Tous, ...
Oncotarget 7 (41), 67033, 2016
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma
I Ferrer, Á Quintanal-Villalonga, S Molina-Pinelo, JM Garcia-Heredia, ...
Journal of Experimental & Clinical Cancer Research 37, 1-13, 2018
Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer
EM Verdugo-Sivianes, L Navas, S Molina-Pinelo, I Ferrer, ...
Oncotarget 8 (62), 105196, 2017
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