Josefa Leon Lopez
Josefa Leon Lopez
Senior Investigator, Hospital Universitario San Cecilio, Granada
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Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
R Reiter, D Tan, J Mayo, R Sainz, J Leon, Z Czarnocki
Acta Biochimica Polonica 50 (4), 1129-1146, 2003
Melatonin mitigates mitochondrial malfunction
J Leon, D Acuña‐Castroviejo, G Escames, DX Tan, RJ Reiter
Journal of pineal research 38 (1), 1-9, 2005
Melatonin, mitochondria, and cellular bioenergetics
D Acuña‐Castroviejo, M Martín, M Macías, G Escames, J León, H Khaldy, ...
Journal of pineal research 30 (2), 65-74, 2001
Melatonin but not vitamins C and E maintains glutathione homeostasis in t‐butyl hydroperoxide‐induced mitochondrial oxidative stress
M Martín, M Macías, G Escames, J León, D Acuña-Castroviejo
The FASEB Journal 14 (12), 1677-1679, 2000
Melatonin and mitochondrial function
J Leon, D Acuña-Castroviejo, RM Sainz, JC Mayo, DX Tan, RJ Reiter
Life sciences 75 (7), 765-790, 2004
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
JC Mayo, RM Sainz, DX Tan, R Hardeland, J Leon, C Rodriguez, ...
Journal of neuroimmunology 165 (1-2), 139-149, 2005
Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria
M Martı́n, M Macı́as, J León, G Escames, H Khaldy, D Acuña-Castroviejo
The international journal of biochemistry & cell biology 34 (4), 348-357, 2002
Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage.
KU Reiter RJ, Tan DX, Gitto E, Sainz RM, Mayo JC, Leon J, Manchester LC ...
Polish Journal of Pharmacology 56 (2), 159-170, 2004
When melatonin gets on your nerves: its beneficial actions in experimental models of stroke
RJ Reiter, D Tan, J Leon, Ü Kilic, E Kilic
Experimental biology and medicine 230 (2), 104-117, 2005
Melatonin counteracts lipopolysaccharide‐induced expression and activity of mitochondrial nitric oxide synthase in rats
G Escames, J León, M Macías, H Khaldy, D Acuña-Castroviejo
The FASEB Journal 17 (8), 1-22, 2003
Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism
RM Sainz, JC Mayo, D Tan, J León, L Manchester, RJ Reiter
The Prostate 63 (1), 29-43, 2005
Inhibition of neuronal nitric oxide synthase activity by N1‐acetyl‐5‐methoxykynuramine, a brain metabolite of melatonin
J León, G Escames, MI Rodríguez, LC López, V Tapias, A Entrena, ...
Journal of neurochemistry 98 (6), 2023-2033, 2006
Melatonin, mitochondrial homeostasis and mitochondrial-related diseases
D Castroviejo, G Escames, A Carazo, J León, H Khaldy, RJ Reiter
Current topics in medicinal chemistry 2 (2), 133-151, 2002
Mitochondrial regulation by melatonin and its metabolites
D Acuña-Castroviejo, G Escames, J LeÓn, A Carazo, H Khaldy
Developments in tryptophan and serotonin metabolism, 549-557, 2003
Melatonin counteracts inducible mitochondrial nitric oxide synthase‐dependent mitochondrial dysfunction in skeletal muscle of septic mice
G Escames, LC López, V Tapias, P Utrilla, RJ Reiter, AB Hitos, J León, ...
Journal of pineal research 40 (1), 71-78, 2006
Structure-related inhibition of calmodulin-dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines
J León, M Macías, G Escames, E Camacho, H Khaldy, M Martín, ...
Molecular pharmacology 58 (5), 967-975, 2000
Calreticulin–melatonin: An unexpected relationship
M Macías, G Escames, J Leon, A Coto, Y Sbihi, A Osuna, ...
European journal of biochemistry 270 (5), 832-840, 2003
Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence
G Escames, D Acuña‐Castroviejo, LC López, D Tan, MD Maldonado, ...
Journal of pharmacy and pharmacology 58 (9), 1153-1165, 2006
Genetic variation in interleukin 28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV‐infected children
Á Ruiz‐Extremera, JA Muñoz‐Gámez, MA Salmerón‐Ruiz, PM de Rueda, ...
Hepatology 53 (6), 1830-1838, 2011
Circadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and of melatonin treatment
H Khaldy, J León, G Escames, L Bikjdaouene, JJ García, ...
Neuroendocrinology 75 (3), 201-208, 2002
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