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George A. Garcia
George A. Garcia
Professor of Medicinal Chemistry, University of Michigan
Dirección de correo verificada de umich.edu
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Oxygen isotope systematics of biologically mediated reactions of phosphate: I. Microbial degradation of organophosphorus compounds
RE Blake, JR O'neil, GA Garcia
Geochimica et Cosmochimica Acta 61 (20), 4411-4422, 1997
2941997
Rifamycins–obstacles and opportunities
PA Aristoff, GA Garcia, PD Kirchhoff, HDH Showalter
Tuberculosis 90 (2), 94-118, 2010
2212010
Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria
MM Meyer, A Roth, SM Chervin, GA Garcia, RR Breaker
Rna 14 (4), 685-695, 2008
1452008
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis
R Brenk, L Naerum, U Grädler, HD Gerber, GA Garcia, K Reuter, ...
Journal of medicinal chemistry 46 (7), 1133-1143, 2003
1282003
Effects of microbial activity on the δ18O of dissolved inorganic phosphate and textural features of synthetic apatites
RE Blake, JR O’Neil, GA Garcia
American Mineralogist 83 (11), 1516-1531, 1998
1211998
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase
U Grädler, HD Gerber, DAM Goodenough-Lashua, GA Garcia, R Ficner, ...
Journal of molecular biology 306 (3), 455-467, 2001
1042001
tRNA-guanine transglycosylase from Escherichia coli: gross tRNA structural requirements for recognition
AW Curnow, FL Kung, KA Koch, GA Garcia
Biochemistry 32 (19), 5239-5246, 1993
1041993
Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis
V Molodtsov, NT Scharf, MA Stefan, GA Garcia, KS Murakami
Molecular microbiology 103 (6), 1034-1045, 2017
1002017
Enzyme-mediated precipitation of parent drugs from their phosphate prodrugs
T Heimbach, DM Oh, LY Li, N Rodrı́guez-Hornedo, G Garcia, D Fleisher
International journal of pharmaceutics 261 (1), 81-92, 2003
1002003
TRANSFER-RNA-GUANINE TRANSGLYCOSYLASE FROM ESCHERICHIA-COLI-MINIMAL TRANSFER-RNA STRUCTURE AND SEQUENCE REQUIREMENTS FOR RECOGNITION
AW Curnow, GA Garcia
JOURNAL OF BIOLOGICAL CHEMISTRY 270 (29), 17264-17267, 1995
92*1995
tRNA-guanine Transglycosylase from Escherichia coli Minimal tRNA Structure and Sequence Requirements for Recognition
AW Curnow, GA Garcia
Journal of Biological Chemistry 270 (29), 17264-17267, 1995
921995
Characterization of the human tRNA-guanine transglycosylase: Confirmation of the heterodimeric subunit structure
YC Chen, VP Kelly, SV Stachura, GA Garcia
Rna 16 (5), 958-968, 2010
782010
Kinetics and mechanism of benzoylformate decarboxylase using carbon-13 and solvent deuterium isotope effects on benzoylformate and benzoylformate analogs
PM Weiss, GA Garcia, GL Kenyon, WW Cleland, PF Cook
Biochemistry 27 (6), 2197-2205, 1988
771988
X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins
V Molodtsov, IN Nawarathne, NT Scharf, PD Kirchhoff, HDH Showalter, ...
Journal of medicinal chemistry 56 (11), 4758-4763, 2013
642013
tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1
GC Hoops, LB Townsend, GA Garcia
Biochemistry 34 (46), 15381-15387, 1995
641995
Site-specific modification of Shigella flexneri virF mRNA by tRNA-guanine transglycosylase in vitro
JK Hurt, S Olgen, GA Garcia
Nucleic acids research 35 (14), 4905-4913, 2007
612007
Transglycosylation: a mechanism for RNA modification (and editing?)
GA Garcia, JD Kittendorf
Bioorganic chemistry 33 (3), 229-251, 2005
572005
Rifamycin inhibition of WT and Rif-resistant Mycobacterium tuberculosis and Escherichia coli RNA polymerases in vitro
SK Gill, GA Garcia
Tuberculosis 91 (5), 361-369, 2011
562011
tRNA–guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis
DAM Goodenough-Lashua, GA Garcia
Bioorganic chemistry 31 (4), 331-344, 2003
562003
tRNA-guanine transglycosylase from Escherichia coli: overexpression, purification and quaternary structure
GA Garcia, KA Koch, S Chong
Journal of molecular biology 231 (2), 489-497, 1993
521993
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Artículos 1–20