Gary B. Evans
Gary B. Evans
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Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase
A Lewandowicz, PC Tyler, GB Evans, RH Furneaux, VL Schramm
Journal of Biological Chemistry 278 (34), 31465-31468, 2003
1612003
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function
W Shi, LM Ting, GA Kicska, A Lewandowicz, PC Tyler, GB Evans, ...
Journal of Biological Chemistry 279 (18), 18103-18106, 2004
1562004
Femtomolar transition state analogue inhibitors of 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli
V Singh, GB Evans, DH Lenz, JM Mason, K Clinch, S Mee, GF Painter, ...
Journal of Biological Chemistry 280 (18), 18265-18273, 2005
1532005
Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes
K Nicolson, G Evans, PW O'Toole
FEMS microbiology letters 179 (2), 233-239, 1999
1511999
Purine-less Death in Plasmodium falciparumInduced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase
GA Kicska, PC Tyler, GB Evans, RH Furneaux, VL Schramm, K Kim
Journal of Biological Chemistry 277 (5), 3226-3231, 2002
1412002
Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins
LM Ting, W Shi, A Lewandowicz, V Singh, A Mwakingwe, MR Birck, ...
Journal of Biological Chemistry 280 (10), 9547-9554, 2005
1282005
Exploring structure− activity relationships of transition state analogues of human purine nucleoside phosphorylase
GB Evans, RH Furneaux, A Lewandowicz, VL Schramm, PC Tyler
Journal of medicinal chemistry 46 (15), 3412-3423, 2003
1162003
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase
GB Evans, RH Furneaux, A Lewandowicz, VL Schramm, PC Tyler
Journal of medicinal chemistry 46 (24), 5271-5276, 2003
1122003
Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum
GA Kicska, PC Tyler, GB Evans, RH Furneaux, K Kim, VL Schramm
Journal of Biological Chemistry 277 (5), 3219-3225, 2002
1092002
Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins
GB Evans, RH Furneaux, TL Hutchison, HS Kezar, PE Morris, ...
The Journal of organic chemistry 66 (17), 5723-5730, 2001
1022001
Quorum sensing controls adaptive immunity through the regulation of multiple CRISPR-Cas systems
AG Patterson, SA Jackson, C Taylor, GB Evans, GPC Salmond, ...
Molecular cell 64 (6), 1102-1108, 2016
1002016
Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction
GB Evans, RH Furneaux, PC Tyler, VL Schramm
Organic letters 5 (20), 3639-3640, 2003
952003
Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases
GB Evans, RH Furneaux, GJ Gainsford, VL Schramm, PC Tyler
Tetrahedron 56 (19), 3053-3062, 2000
952000
Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases
RW Miles, PC Tyler, GB Evans, RH Furneaux, DW Parkin, VL Schramm
Biochemistry 38 (40), 13147-13154, 1999
921999
Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases
GB Evans, RH Furneaux, B Greatrex, AS Murkin, VL Schramm, PC Tyler
Journal of medicinal chemistry 51 (4), 948-956, 2008
822008
Structural rationale for the affinity of pico-and femtomolar transition state analogues of Escherichia coli 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase
JE Lee, V Singh, GB Evans, PC Tyler, RH Furneaux, KA Cornell, ...
Journal of Biological Chemistry 280 (18), 18274-18282, 2005
792005
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase
GA Kicska, PC Tyler, GB Evans, RH Furneaux, W Shi, A Fedorov, ...
Biochemistry 41 (49), 14489-14498, 2002
792002
Picomolar transition state analogue inhibitors of human 5 ‘-methylthioadenosine phosphorylase and X-ray structure with MT-Immucillin-A
V Singh, W Shi, GB Evans, PC Tyler, RH Furneaux, SC Almo, ...
Biochemistry 43 (1), 9-18, 2004
782004
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase
I Basu, J Locker, MB Cassera, TJ Belbin, EF Merino, X Dong, I Hemeon, ...
Journal of Biological Chemistry 286 (6), 4902-4911, 2011
762011
Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases
K Clinch, GB Evans, GWJ Fleet, RH Furneaux, SW Johnson, DH Lenz, ...
Organic & biomolecular chemistry 4 (6), 1131-1139, 2006
752006
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