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Maxwell A. Stefan
Maxwell A. Stefan
Postdoctoral Research Scientist, Sandia National Laboratories
Dirección de correo verificada de sandia.gov
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Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis
V Molodtsov, NT Scharf, MA Stefan, GA Garcia, KS Murakami
Molecular microbiology 103 (6), 1034-1045, 2017
1002017
Source of the fitness defect in rifamycin-resistant Mycobacterium tuberculosis RNA polymerase and the mechanism of compensation by mutations in the β′ subunit
MA Stefan, FS Ugur, GA Garcia
Antimicrobial agents and chemotherapy 62 (6), 10.1128/aac. 00164-18, 2018
342018
Discovery of small-molecule inhibitors of SARS-CoV-2 proteins using a computational and experimental pipeline
EY Lau, OA Negrete, WFD Bennett, BJ Bennion, M Borucki, F Bourguet, ...
Frontiers in Molecular Biosciences 8, 678701, 2021
222021
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
MA Stefan, YK Light, JL Schwedler, PR McIlroy, CM Courtney, EA Saada, ...
MAbs 13 (1), 1958663, 2021
152021
High-throughput virtual screening of small molecule inhibitors for SARS-CoV-2 protein targets with deep fusion models
GA Stevenson, D Jones, H Kim, WFD Bennett, BJ Bennion, M Borucki, ...
Proceedings of the International Conference for High Performance Computing …, 2021
122021
High-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis
MA Stefan, GM Velazquez, GA Garcia
Scientific reports 10 (1), 21309, 2020
92020
Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function
JL Schwedler, MA Stefan, CE Thatcher, PR McIlroy, A Sinha, AM Phillips, ...
Mabs 16 (1), 2297451, 2024
12024
High-Throughput Virtual Screening of Small Molecule Inhibitors for SARS-CoV-2 Protein Targets with Deep Fusion Models (preprint)
GA Stevenson, D Jones, H Kim, WFD Bennett, BJ Bennion, M Borucki, ...
12021
Therapeutic efficacy of a potent anti-VEEV antibody is contingent on humoral and cell-mediated cytotoxic immunity.
J Schwedler, M Stefan, A Sinha, P Mcilroy, C Thatcher, C Kim, ...
Sandia National Lab.(SNL-CA), Livermore, CA (United States), 2022
2022
Characterization of SNL identified BBB-penetrating moieties (BBB PMs) for delivery of therapeutic cargo to the CNS.
C Sumner, J Schwedler, M Stefan, A Sinha, P Mcilroy, C Thatcher, CY Kim, ...
Sandia National Lab.(SNL-CA), Livermore, CA (United States), 2022
2022
DISCOVERY, DESIGN, AND ENGINEERING OF NANOBODY-BASED THERAPEUTICS FOR SARS-COV-2.
B Harmon, LTM Pham, P Mcilroy, A Sinha, J Jaryenneh, Y Light, ...
Sandia National Lab.(SNL-CA), Livermore, CA (United States); Sandia National …, 2022
2022
Protein Display to Discover and Engineer Viral Neutralizing Antibodies.
M Stefan, B Harmon, J Schwedler
Sandia National Lab.(SNL-NM), Albuquerque, NM (United States), 2021
2021
Development of Potent and Effective SARS-CoV-2 Neutralizing Nanobodies.
M Stefan, YK Light, J Schwedler, DR Weilhammer, BN Harmon
Sandia National Lab.(SNL-CA), Livermore, CA (United States), 2021
2021
Combining Computational Modeling with Library Screening to Adapt SARS-CoV-Neutralizing Antibody 80R to SARS-CoV-2
MS Kent, M Stefan, K Sale, C Hudson, D Martinez, M Juarros, B Harmon, ...
Biophysical Journal 120 (3), 21a, 2021
2021
Development of Potent and Effective Synthetic SARS-CoV-2 Neutralizing Nanobodies (preprint)
M Stefan, Y Light, J Schwedler, P McIlroy, C Courtney, E Saada, ...
2021
Rapidly Adapting Neutralizing Antibodies to Related Virus Types and Subtypes.
MS Kent, M Stefan, BN Harmon, D Gelperin, V Duva, A Wynne, ...
Sandia National Lab.(SNL-NM), Albuquerque, NM (United States); Sandia …, 2021
2021
Adapting Neutralizing Antibodies to Related Virus Types and Subtypes.
MS Kent, M Stefan, BN Harmon
Sandia National Lab.(SNL-NM), Albuquerque, NM (United States); Sandia …, 2020
2020
Deactivation of SARS-CoV-2 by Boronic Acid-Functionalized Polymer
GD Bachand, BN Harmon, BH Jones, PR Miller, JB Ricken, M Stefan
Sandia National Lab.(SNL-NM), Albuquerque, NM (United States); Sandia …, 2020
2020
Development of Blood Brain Barrier Penetrating Antibody Therapeutics for Encephalitic Alphaviruses.
M Stefan, J Schwedler, BN Harmon, D Weilhammer, M Diamond
Sandia National Lab.(SNL-CA), Livermore, CA (United States), 2019
2019
Characterizing differential expression of transmembrane protein 30A.
N Friedberg, J Schwedler, M Stefan, BN Harmon
Sandia National Lab.(SNL-CA), Livermore, CA (United States), 2019
2019
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Artículos 1–20