| Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo S EL Andaloussi, T Lehto, I Mäger, K Rosenthal-Aizman, II Oprea, ... Nucleic acids research 39 (9), 3972-3987, 2011 | 327 | 2011 |
| PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation K Ezzat, S EL Andaloussi, EM Zaghloul, T Lehto, S Lindberg, ... Nucleic acids research 39 (12), 5284-5298, 2011 | 288 | 2011 |
| Cell-penetrating peptides for the delivery of nucleic acids T Lehto, K Kurrikoff, Ü Langel Expert Opinion on Drug Delivery 9 (7), 823-836, 2012 | 231 | 2012 |
| Peptides for nucleic acid delivery T Lehto, K Ezzat, MJA Wood, SEL Andaloussi Advanced drug delivery reviews 106, 172-182, 2016 | 224 | 2016 |
| Delivery of oligonucleotide‐based therapeutics: challenges and opportunities SM Hammond, A Aartsma‐Rus, S Alves, SE Borgos, RAM Buijsen, ... EMBO Molecular Medicine 13 (4), e13243, 2021 | 211 | 2021 |
| Delivery is key: lessons learnt from developing splice‐switching antisense therapies C Godfrey, LR Desviat, B Smedsrød, F Piétri‐Rouxel, MA Denti, P Disterer, ... EMBO molecular medicine 9 (5), 545-557, 2017 | 158 | 2017 |
| Delivery of nucleic acids with a stearylated (RxR) 4 peptide using a non-covalent co-incubation strategy T Lehto, R Abes, N Oskolkov, J Suhorutšenko, DM Copolovici, I Mäger, ... Journal of Controlled Release 141 (1), 42-51, 2010 | 151 | 2010 |
| Sensitive and rapid detection of Chlamydia trachomatis by recombinase polymerase amplification directly from urine samples K Krõlov, J Frolova, O Tudoran, J Suhorutsenko, T Lehto, H Sibul, I Mäger, ... The Journal of Molecular Diagnostics 16 (1), 127-135, 2014 | 149 | 2014 |
| A peptide-based vector for efficient gene transfer in vitro and in vivo T Lehto, OE Simonson, I Mäger, K Ezzat, H Sork, DM Copolovici, JR Viola, ... Molecular Therapy 19 (8), 1457-1467, 2011 | 138 | 2011 |
| Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides K Ezzat, Y Aoki, T Koo, G McClorey, L Benner, A Coenen-Stass, ... Nano letters 15 (7), 4364-4373, 2015 | 103 | 2015 |
| The role of endocytosis on the uptake kinetics of luciferin-conjugated cell-penetrating peptides I Mäger, K Langel, T Lehto, E Eiríksdóttir, Ü Langel Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (3), 502-511, 2012 | 102 | 2012 |
| PepFect14 peptide vector for efficient gene delivery in cell cultures KL Veiman, I Mäger, K Ezzat, H Margus, T Lehto, K Langel, K Kurrikoff, ... Molecular pharmaceutics 10 (1), 199-210, 2013 | 101 | 2013 |
| Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells T Lehto, A Castillo Alvarez, S Gauck, MJ Gait, T Coursindel, MJA Wood, ... Nucleic acids research 42 (5), 3207-3217, 2014 | 97 | 2014 |
| Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles JP Bost, H Barriga, MN Holme, A Gallud, M Maugeri, D Gupta, T Lehto, ... ACS nano 15 (9), 13993-14021, 2021 | 92 | 2021 |
| Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand DJ Lee, E Kessel, D Edinger, D He, PM Klein, LV von Voithenberg, ... Biomaterials 77, 98-110, 2016 | 73 | 2016 |
| Chemically modified cell-penetrating peptides for the delivery of nucleic acids M Mäe, SE Andaloussi, T Lehto, Ü Langel Expert opinion on drug delivery 6 (11), 1195-1205, 2009 | 68 | 2009 |
| Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions K Ezzat, EM Zaghloul, SEL Andaloussi, T Lehto, R El-Sayed, T Magdy, ... Journal of Controlled Release 162 (1), 1-8, 2012 | 65 | 2012 |
| mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells S Bevers, SAA Kooijmans, E Van de Velde, MJW Evers, S Seghers, ... Molecular Therapy, 2022 | 61 | 2022 |
| Cellular internalization kinetics of (luciferin-) cell-penetrating peptide conjugates E Eiríksdóttir, I Mäger, T Lehto, S El Andaloussi, U Langel Bioconjugate chemistry 21 (9), 1662-1672, 2010 | 57 | 2010 |
| Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia DJ Lee, E Kessel, T Lehto, X Liu, N Yoshinaga, K Padari, YC Chen, ... Bioconjugate chemistry 28 (9), 2393-2409, 2017 | 53 | 2017 |
