Follow
Patrick Caffrey
Patrick Caffrey
Verified email at ucd.ie
Title
Cited by
Cited by
Year
Minimum information about a biosynthetic gene cluster
MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ...
Nature chemical biology 11 (9), 625-631, 2015
8332015
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
T Schwecke, JF Aparicio, I Molnar, A König, LE Khaw, SF Haydock, ...
Proceedings of the National Academy of Sciences 92 (17), 7839-7843, 1995
6121995
Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases
P Caffrey
ChemBioChem 4 (7), 654-657, 2003
4102003
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes
P Caffrey, S Lynch, E Flood, S Finnan, M Oliynyk
Chemistry & biology 8 (7), 713-723, 2001
3242001
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase
AFA Marsden, P Caffrey, JF Aparicio, MS Loughran, J Staunton, ...
Science 263 (5145), 378-380, 1994
2101994
Polyene antibiotic biosynthesis gene clusters
JF Aparicio, P Caffrey, JA Gil, SB Zotchev
Applied microbiology and biotechnology 61, 179-188, 2003
1872003
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea
P Caffrey, DJ Bevitt, J Staunton, PF Leadlay
FEBS letters 304 (2-3), 225-228, 1992
1831992
Evidence for a double-helical structure for modular polyketide synthases
J Staunton, P Caffrey, JF Aparicio, GA Roberts, SS Bethell, PF Leadlay
Nature structural biology 3 (2), 188-192, 1996
1821996
Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups
M Carmody, B Murphy, B Byrne, P Power, D Rai, B Rawlings, P Caffrey
Journal of Biological Chemistry 280 (41), 34420-34426, 2005
1222005
Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase.
JF Aparicio, P Caffrey, AF Marsden, J Staunton, PF Leadlay
Journal of Biological Chemistry 269 (11), 8524-8528, 1994
1151994
Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents
P Caffrey, JF Aparicio, F Malpartida, SB Zotchev
Current topics in medicinal chemistry 8 (8), 639-653, 2008
1022008
Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus
B Byrne, M Carmody, E Gibson, B Rawlings, P Caffrey
Chemistry & biology 10 (12), 1215-1224, 2003
852003
Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques
M Carmody, B Byrne, B Murphy, C Breen, S Lynch, E Flood, S Finnan, ...
Gene 343 (1), 107-115, 2004
712004
An acyl‐carrier‐protein – thioesterase domain from the 6‐deoxyerythronolide B synthase of Saccharopolyspora erythraea High‐level production, purification and …
P Caffrey, B Green, LC Packman, BJ Rawlings, J Staunton, PF Leadlay
European journal of biochemistry 195 (3), 823-830, 1991
681991
Engineered synthesis of 7-oxo-and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics
P Power, T Dunne, B Murphy, LN Lochlainn, D Rai, C Borissow, ...
Chemistry & biology 15 (1), 78-86, 2008
562008
Purification and N-terminal sequence of the alpha subunit of antigen 43, a unique protein complex associated with the outer membrane of Escherichia coli
P Caffrey, P Owen
Journal of bacteriology 171 (7), 3634-3640, 1989
551989
The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity
R Aggarwal, P Caffrey, PF Leadlay, CJ Smith, J Staunton
Journal of the Chemical Society, Chemical Communications, 1519-1520, 1995
501995
Identification and partial characterization of a novel bipartite protein antigen associated with the outer membrane of Escherichia coli
P Owen, P Caffrey, LG Josefsson
Journal of bacteriology 169 (8), 3770-3777, 1987
491987
Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies
P Caffrey, E De Poire, J Sheehan, P Sweeney
Applied microbiology and biotechnology 100, 3893-3908, 2016
482016
Redesign of polyene macrolide glycosylation: engineered biosynthesis of 19-(O)-perosaminyl-amphoteronolide B
E Hutchinson, B Murphy, T Dunne, C Breen, B Rawlings, P Caffrey
Chemistry & biology 17 (2), 174-182, 2010
482010
The system can't perform the operation now. Try again later.
Articles 1–20