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Justin EYQUEM
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Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
J Eyquem, J Mansilla-Soto, T Giavridis, SJC van der Stegen, M Hamieh, ...
Nature 543 (7643), 113-117, 2017
16942017
CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade
T Giavridis, SJC van der Stegen, J Eyquem, M Hamieh, A Piersigilli, ...
Nature medicine 24 (6), 731-738, 2018
10672018
Multiplex genome-edited T-cell manufacturing platform for “off-the-shelf” adoptive T-cell immunotherapies
L Poirot, B Philip, C Schiffer-Mannioui, D Le Clerre, I Chion-Sotinel, ...
Cancer research 75 (18), 3853-3864, 2015
6222015
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape
M Hamieh, A Dobrin, A Cabriolu, SJC van der Stegen, T Giavridis, ...
Nature 568 (7750), 112-116, 2019
4842019
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency
J Feucht, J Sun, J Eyquem, YJ Ho, Z Zhao, J Leibold, A Dobrin, A Cabriolu, ...
Nature medicine 25 (1), 82-88, 2019
4192019
Integrating proteomics and transcriptomics for systematic combinatorial chimeric antigen receptor therapy of AML
F Perna, SH Berman, RK Soni, J Mansilla-Soto, J Eyquem, M Hamieh, ...
Cancer cell 32 (4), 506-519. e5, 2017
2742017
Low-dose radiation conditioning enables CAR T cells to mitigate antigen escape
C DeSelm, ML Palomba, J Yahalom, M Hamieh, J Eyquem, ...
Molecular Therapy 26 (11), 2542-2552, 2018
1902018
A platform for rapid prototyping of synthetic gene networks in mammalian cells
X Duportet, L Wroblewska, P Guye, Y Li, J Eyquem, J Rieders, T Rimchala, ...
Nucleic acids research 42 (21), 13440-13451, 2014
1522014
HLA-independent T cell receptors for targeting tumors with low antigen density
J Mansilla-Soto, J Eyquem, S Haubner, M Hamieh, J Feucht, N Paillon, ...
Nature medicine 28 (2), 345-352, 2022
882022
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
BR Shy, VS Vykunta, A Ha, A Talbot, TL Roth, DN Nguyen, WG Pfeifer, ...
Nature biotechnology 41 (4), 521-531, 2023
832023
The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28
YD Muller, DP Nguyen, LMR Ferreira, P Ho, C Raffin, RVB Valencia, ...
Frontiers in immunology 12, 639818, 2021
812021
Multi-chain chimeric antigen receptor and uses thereof
J Smith, A Scharenberg, C Mannioui, J Eyquem
US Patent 10,342,829, 2019
742019
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
J Carnevale, E Shifrut, N Kale, WA Nyberg, F Blaeschke, YY Chen, Z Li, ...
Nature 609 (7925), 174-182, 2022
712022
Antibody with infinite affinity for in vivo tracking of genetically engineered lymphocytes
S Krebs, A Ahad, LM Carter, J Eyquem, C Brand, M Bell, V Ponomarev, ...
Journal of Nuclear Medicine 59 (12), 1894-1900, 2018
422018
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance
ID Ferguson, B Patiño-Escobar, ST Tuomivaara, YHT Lin, MA Nix, ...
Nature communications 13 (1), 4121, 2022
382022
Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells
SJC van der Stegen, PL Lindenbergh, RM Petrovic, H Xie, MP Diop, ...
Nature biomedical engineering 6 (11), 1284-1297, 2022
342022
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
CA Tsuchida, N Brandes, R Bueno, M Trinidad, T Mazumder, B Yu, ...
Cell 186 (21), 4567-4582. e20, 2023
332023
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes
DV Foss, JJ Muldoon, DN Nguyen, D Carr, SU Sahu, JM Hunsinger, ...
Nature Biomedical Engineering 7 (5), 647-660, 2023
302023
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
DB Goodman, CS Azimi, K Kearns, A Talbot, K Garakani, J Garcia, ...
Science translational medicine 14 (670), eabm1463, 2022
292022
An evolved AAV variant enables efficient genetic engineering of murine T cells
WA Nyberg, J Ark, A To, S Clouden, G Reeder, JJ Muldoon, JY Chung, ...
Cell 186 (2), 446-460. e19, 2023
212023
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