Amaury Pupo
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Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation
A Talavera, R Friemann, S Gómez-Puerta, C Martinez-Fleites, G Garrido, ...
Cancer research 69 (14), 5851-5859, 2009
Connexinopathies: a structural and functional glimpse
IE García, P Prado, A Pupo, O Jara, D Rojas-Gómez, P Mujica, ...
BMC cell biology 17 (1), 71-87, 2016
From hyperactive connexin26 hemichannels to impairments in epidermal calcium gradient and permeability barrier in the keratitis-ichthyosis-deafness syndrome
IE Garcia, F Bosen, P Mujica, A Pupo, C Flores-Munoz, O Jara, ...
Journal of Investigative Dermatology 136 (3), 574-583, 2016
Structural and functional characterization of a recombinant sticholysin I (rSt I) from the sea anemone Stichodactyla helianthus
F Pazos, A Valle, D Martínez, A Ramírez, L Calderón, A Pupo, M Tejuca, ...
Toxicon 48 (8), 1083-1094, 2006
Molecular mechanism underlying β1 regulation in voltage-and calcium-activated potassium (BK) channels
K Castillo, GF Contreras, A Pupo, YP Torres, A Neely, C González, ...
Proceedings of the National Academy of Sciences 112 (15), 4809-4814, 2015
Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor
H Lamdan, JV Gavilondo, Y Munoz, A Pupo, V Huerta, A Musacchio, ...
Molecular BioSystems 9 (8), 2097-2106, 2013
Extracellular cysteine in connexins: role as redox sensors
MA Retamal, IE García, BI Pinto, A Pupo, D Báez, J Stehberg, R Del Rio, ...
Frontiers in physiology 7, 1, 2016
Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: a versatile platform for fine epitope mapping
G Rojas, A Pupo, K Leon, J Avellanet, T Carmenate, S Sidhu
Immunobiology 218 (1), 105-113, 2013
Fine epitope specificity of antibodies against interleukin-2 explains their paradoxical immunomodulatory effects
G Rojas, Y Cabrera Infante, A Pupo, T Carmenate
MAbs 6 (1), 273-285, 2014
Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations
PA Valiente, PR Batista, A Pupo, T Pons, A Valencia, PG Pascutti
Proteins: Structure, Function, and Bioinformatics 73 (2), 440-457, 2008
Engineering the Binding Site of an Antibody against N-Glycolyl GM3: From Functional Mapping to Novel Anti-ganglioside Specificities
G Rojas, A Pupo, S Gómez, U Krengel, E Moreno
ACS Chemical Biology 8 (2), 376-386, 2013
A combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen: application to antibodies against epidermal growth factor
YC Infante, A Pupo, G Rojas
MAbs 6 (3), 637-648, 2014
Pharmacological modulation of proton channel Hv1 in cancer therapy: future perspectives
A Fernández, A Pupo, K Mena-Ulecia, C Gonzalez
Molecular pharmacology 90 (3), 385-402, 2016
Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor
Y Tundidor, CP García-Hernández, A Pupo, YC Infante, G Rojas
MAbs 6 (4), 1013-1025, 2014
Proton channel models: filling the gap between experimental data and the structural rationale
A Pupo, D Baez-Nieto, A Martínez, R Latorre, C González
Channels 8 (3), 180-192, 2014
Carbon monoxide: A new player in the redox regulation of connexin hemichannels
MA Retamal, CG León‐Paravic, M Ezquer, F Ezquer, RD Rio, A Pupo, ...
IUBMB life 67 (6), 428-437, 2015
Calcium binding and voltage gating in Cx46 hemichannels
BI Pinto, A Pupo, IE García, K Mena-Ulecia, AD Martínez, R Latorre, ...
Scientific Reports 7 (1), 15851, 2017
Voltage-dependent BK and Hv1 channels expressed in non-excitable tissues: New therapeutics opportunities as targets in human diseases
FJ Morera, J Saravia, JP Pontigo, L Vargas-Chacoff, GF Contreras, ...
Pharmacological Research 101, 56-64, 2015
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels
IE García, F Villanelo, GF Contreras, A Pupo, BI Pinto, JE Contreras, ...
Journal of General Physiology 150 (5), 697-711, 2018
Charged residues at the first transmembrane region contribute to the voltage dependence of the slow gate of connexins
BI Pinto, IE García, A Pupo, MA Retamal, AD Martínez, R Latorre, ...
Journal of Biological Chemistry 291 (30), 15740-15752, 2016
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