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David Vilchez
David Vilchez
CECAD and Institute for Genetics, University of Cologne
Dirección de correo verificada de uni-koeln.de - Página principal
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The role of protein clearance mechanisms in organismal ageing and age-related diseases
D Vilchez, I Saez, A Dillin
Nature communications 5 (1), 5659, 2014
6732014
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
D Vilchez, I Morantte, Z Liu, PM Douglas, C Merkwirth, APC Rodrigues, ...
Nature 489 (7415), 263-268, 2012
4302012
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
D Vilchez, S Ros, D Cifuentes, L Pujadas, J Vallès, B García-Fojeda, ...
Nature neuroscience 10 (11), 1407-1413, 2007
4302007
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11
D Vilchez, L Boyer, I Morantte, M Lutz, C Merkwirth, D Joyce, B Spencer, ...
Nature 489 (7415), 304-308, 2012
4042012
The mechanistic links between proteasome activity, aging and agerelated diseases
I Saez, D Vilchez
Current genomics 15 (1), 38-51, 2014
3282014
Regulation of glycogen synthesis by the laforin–malin complex is modulated by the AMP-activated protein kinase pathway
MC Solaz-Fuster, JV Gimeno-Alcañiz, S Ros, ME Fernandez-Sanchez, ...
Human molecular genetics 17 (5), 667, 2008
1632008
Proteostasis and aging of stem cells
D Vilchez, MS Simic, A Dillin
Trends in cell biology 24 (3), 161-170, 2014
1552014
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
C Kumsta, JT Chang, R Lee, EP Tan, Y Yang, R Loureiro, EH Choy, ...
Nature Communications 10 (1), 5648, 2019
932019
The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
S Koyuncu, I Saez, HJ Lee, R Gutierrez-Garcia, W Pokrzywa, A Fatima, ...
Nature Communications 9 (1), 2886, 2018
902018
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
A Noormohammadi, A Khodakarami, R Gutierrez-Garcia, HJ Lee, ...
Nature communications 7 (1), 13649, 2016
842016
A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
H Ju Lee, D Bartsch, C Xiao, S Guerrero, G Ahuja, C Schindler, ...
Nature communications 8 (1), 1456, 2017
722017
Rewiring of the ubiquitinated proteome determines ageing in C. elegans
S Koyuncu, R Loureiro, HJ Lee, P Wagle, M Krueger, D Vilchez
Nature 596 (7871), 285-290, 2021
702021
DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis
A Thiruvalluvan, EP de Mattos, JF Brunsting, R Bakels, D Serlidaki, ...
Molecular cell 78 (2), 346-358. e9, 2020
642020
Proteostasis of huntingtin in health and disease
S Koyuncu, A Fatima, R Gutierrez-Garcia, D Vilchez
International journal of molecular sciences 18 (7), 1568, 2017
592017
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes
MM Rinschen, P Bharill, X Wu, P Kohli, MJ Reinert, O Kretz, I Saez, ...
Human molecular genetics 25 (7), 1328-1344, 2016
562016
Insights into the ubiquitin-proteasome system of human embryonic stem cells
I Saez, S Koyuncu, R Gutierrez-Garcia, C Dieterich, D Vilchez
Scientific reports 8 (1), 4092, 2018
502018
Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells
A Noormohammadi, G Calculli, R Gutierrez-Garcia, A Khodakarami, ...
Cellular and Molecular Life Sciences 75, 275-290, 2018
492018
FOXO 4 is necessary for neural differentiation of human embryonic stem cells
D Vilchez, L Boyer, M Lutz, C Merkwirth, I Morantte, C Tse, B Spencer, ...
Aging cell 12 (3), 518-522, 2013
482013
Embryonic stem cells: a novel paradigm to study proteostasis?
HJ Lee, R Gutierrez‐Garcia, D Vilchez
The FEBS journal 284 (3), 391-398, 2017
392017
Resveratrol confers neuroprotection against high-fat diet in a mouse model of Alzheimer's disease via modulation of proteolytic mechanisms
S Sarroca, A Gatius, E Rodríguez-Farré, D Vilchez, M Pallàs, ...
The Journal of nutritional biochemistry 89, 108569, 2021
352021
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Artículos 1–20