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Patrick M. Buck
Patrick M. Buck
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Dirección de correo verificada de umich.edu
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Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties
L Li, S Kumar, PM Buck, C Burns, J Lavoie, SK Singh, NW Warne, ...
Pharmaceutical research 31, 3161-3178, 2014
1272014
Highly viscous antibody solutions are a consequence of network formation caused by domain–domain electrostatic complementarities: Insights from coarse-grained simulations
PM Buck, A Chaudhri, S Kumar, SK Singh
Molecular pharmaceutics 12 (1), 127-139, 2015
1162015
Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions
P Nichols, L Li, S Kumar, PM Buck, SK Singh, S Goswami, B Balthazor, ...
MAbs 7 (1), 212-230, 2015
952015
Computational tool for the early screening of monoclonal antibodies for their viscosities
NJ Agrawal, B Helk, S Kumar, N Mody, HA Sathish, HS Samra, PM Buck, ...
MAbs 8 (1), 43-48, 2016
892016
Computational methods to predict therapeutic protein aggregation
PM Buck, S Kumar, X Wang, NJ Agrawal, BL Trout, SK Singh
Therapeutic proteins: Methods and protocols, 425-451, 2012
652012
On the role of aggregation prone regions in protein evolution, stability, and enzymatic catalysis: insights from diverse analyses
PM Buck, S Kumar, SK Singh
PLoS computational biology 9 (10), e1003291, 2013
542013
Agitation-induced aggregation and subvisible particulate formation in model proteins
M Jayaraman, PM Buck, AA Ignatius, KR King, W Wang
European Journal of Pharmaceutics and Biopharmaceutics 87 (2), 299-309, 2014
422014
Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations
X Wang, S Kumar, PM Buck, SK Singh
Proteins: Structure, Function, and Bioinformatics 81 (3), 443-460, 2013
372013
Consequences of glycan truncation on Fc structural integrity
PM Buck, S Kumar, SK Singh
MAbs 5 (6), 904-916, 2013
352013
Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics
PM Buck, S Kumar, SK Singh
Protein Engineering, Design & Selection 26 (3), 195-206, 2013
192013
Toward computationally designed self-reporting biosensors using leave-one-out green fluorescent protein
Y Huang, S Banerjee, DE Crone, CD Schenkelberg, DJ Pitman, PM Buck, ...
Biochemistry 54 (40), 6263-6273, 2015
142015
Simulating protein folding initiation sites using an alpha‐carbon‐only knowledge‐based force field
PM Buck, C Bystroff
Proteins: Structure, Function, and Bioinformatics 76 (2), 331-342, 2009
72009
Biopharmaceutical informatics: applications of computation in biologic drug development
S Kumar, RH Robins, PM Buck, TP Hickling, AM Thangakani, L Li, ...
Developability of Biotherapeutics: Computational Approaches, 3-34, 2015
62015
Constraining local structure can speed up folding by promoting structural polarization of the folding pathway
PM Buck, C Bystroff
Protein Science 20 (6), 959-969, 2011
52011
Computational tool for the early screening of monoclonal antibodies for their viscosities. mAbs 2016; 8: 43-8; PMID: 26399600
NJ Agrawal, B Helk, S Kumar, N Mody, HA Sathish, HS Samra, PM Buck, ...
2
PIH51 NON-CLINICAL FACTORS ARE THE KEY BARRIER FOR PATIENT ACCESS TO PENILE PROSTHESIS IN EMPLOYER-SPONSORED HEALTH INSURANCE
https://www.valueinhealthjournal.com/article/S1098-3015(20)30634-3/fulltext, 2020
2020
PHP255-EUROPEAN “REAL-WORLD” EVIDENCE FOR DRUGS AND DEVICES: 2017 LITERATURE REVIEWED
M Mordin, C Castro, PM Buck, MM Fernandez, KA Hollis, ME Ritchey
Value in Health 21, S193, 2018
2018
What does “Real World” Evidence Mean? A Review of 2017 Literature
M Mordin, PM Buck, C Castro, MM Fernandez, KA Hollis, ME Ritchey
Value in Health 21, S108, 2018
2018
Applications of Computation in Biologic Drug Development
S Kumar, RH Robins, PM Buck, TP Hickling, AM Thangakani, L Li, ...
Developability of Biotherapeutics: Computational Approaches, 1, 2015
2015
Biopharmaceutical informatics: Understanding behavior of highly concentrated antibody solutions at molecular level via coarse-grained modeling and simulations
DS Tomar, P Buck, S Kumar, S Singh
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 249, 2015
2015
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Artículos 1–20