IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation KM Lin, W Hu, TD Troutman, M Jennings, T Brewer, X Li, S Nanda, ... Proceedings of the National Academy of Sciences 111 (2), 775-780, 2014 | 314 | 2014 |
Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis JS Seidman, TD Troutman, M Sakai, A Gola, NJ Spann, H Bennett, ... Immunity 52 (6), 1057-1074. e7, 2020 | 285 | 2020 |
Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity M Sakai, TD Troutman, JS Seidman, Z Ouyang, NJ Spann, Y Abe, KM Ego, ... Immunity 51 (4), 655-670. e8, 2019 | 264 | 2019 |
Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K TD Troutman, JF Bazan, C Pasare Cell cycle 11 (19), 3559-3567, 2012 | 239 | 2012 |
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt TD Troutman, W Hu, S Fulenchek, T Yamazaki, T Kurosaki, JF Bazan, ... Proceedings of the National Academy of Sciences 109 (1), 273-278, 2012 | 206 | 2012 |
Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function VM Link, SH Duttke, HB Chun, IR Holtman, E Westin, MA Hoeksema, ... Cell 173 (7), 1796-1809. e17, 2018 | 159 | 2018 |
TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation RA Irizarry-Caro, MM McDaniel, GR Overcast, VG Jain, TD Troutman, ... Proceedings of the National Academy of Sciences 117 (48), 30628-30638, 2020 | 148 | 2020 |
Neutralization of oxidized phospholipids ameliorates non-alcoholic steatohepatitis X Sun, JS Seidman, P Zhao, TD Troutman, NJ Spann, X Que, F Zhou, ... Cell metabolism 31 (1), 189-206. e8, 2020 | 138 | 2020 |
Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment W Hu, TD Troutman, R Edukulla, C Pasare Immunity 35 (6), 1010-1022, 2011 | 134 | 2011 |
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages ED Muse, S Yu, CR Edillor, J Tao, NJ Spann, TD Troutman, JS Seidman, ... Proceedings of the National Academy of Sciences 115 (20), E4680-E4689, 2018 | 98 | 2018 |
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells KA Allison, E Sajti, JG Collier, D Gosselin, TD Troutman, EL Stone, ... Elife 5, e10134, 2016 | 80 | 2016 |
Heterogeneity of HSC s in a Mouse Model of NASH SB Rosenthal, X Liu, S Ganguly, D Dhar, MP Pasillas, E Ricciardelli, RZ Li, ... Hepatology 74 (2), 667-685, 2021 | 79 | 2021 |
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages DZ Eichenfield, TD Troutman, VM Link, MT Lam, H Cho, D Gosselin, ... elife 5, e13024, 2016 | 71 | 2016 |
BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic Th17 cell differentiation K Deason, TD Troutman, A Jain, DK Challa, R Mandraju, T Brewer, ... Journal of Experimental Medicine 215 (9), 2413-2428, 2018 | 54 | 2018 |
Epigenetic regulation of kupffer cell function in health and disease H Bennett, TD Troutman, M Sakai, CK Glass Frontiers in Immunology 11, 609618, 2021 | 44 | 2021 |
Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice SM Moore, JS Seidman, J Ellegood, R Gao, A Savchenko, TD Troutman, ... Translational psychiatry 9 (1), 24, 2019 | 37 | 2019 |
Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease TD Troutman, E Kofman, CK Glass Molecular cell 81 (19), 3888-3903, 2021 | 35 | 2021 |
Mannose-containing oligosaccharides of non-specific human secretory immunoglobulin A mediate inhibition of Vibrio cholerae biofilm formation AK Murthy, BKR Chaganty, T Troutman, MN Guentzel, JJ Yu, SK Ali, ... PLoS One 6 (2), e16847, 2011 | 35 | 2011 |
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis K Arimoto, S Miyauchi, TD Troutman, Y Zhang, M Liu, SA Stoner, ... Nature Communications 14 (1), 251, 2023 | 18 | 2023 |
Breaking down the complex pathophysiology of eosinophilic esophagitis B Underwood, TD Troutman, JT Schwartz Annals of Allergy, Asthma & Immunology 130 (1), 28-39, 2023 | 17 | 2023 |