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Jatin Narula
Jatin Narula
Pfizer Inc., Cambridge MA
Dirección de correo verificada de pfizer.com
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Chromosomal arrangement of phosphorelay genes couples sporulation and DNA replication
J Narula, A Kuchina, DL Dong-yeon, M Fujita, GM Süel, OA Igoshin
Cell 162 (2), 328-337, 2015
1032015
Ultrasensitivity of the Bacillus subtilis sporulation decision
J Narula, SN Devi, M Fujita, OA Igoshin
Proceedings of the National Academy of Sciences 109 (50), E3513-E3522, 2012
852012
Bistable responses in bacterial genetic networks: designs and dynamical consequences
A Tiwari, JCJ Ray, J Narula, OA Igoshin
Mathematical biosciences 231 (1), 76-89, 2011
812011
Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate
J Narula, AM Smith, B Gottgens, OA Igoshin
PLoS computational biology 6 (5), e1000771, 2010
762010
Impaired angiogenesis in aging myocardial microvascular endothelial cells is associated with reduced importin alpha and decreased nuclear transport of HIF1 alpha: mechanistic …
A Ahluwalia, J Narula, MK Jones, X Deng, AS Tarnawski
Journal of physiology and pharmacology: an official journal of the Polish …, 2010
572010
Triggering sporulation in Bacillus subtilis with artificial two‐component systems reveals the importance of proper Spo0A activation dynamics
M Vishnoi, J Narula, SN Devi, HA Dao, OA Igoshin, M Fujita
Molecular microbiology 90 (1), 181-194, 2013
562013
Maximum entropy production allows a simple representation of heterogeneity in semiarid ecosystems
SJ Schymanski, A Kleidon, M Stieglitz, J Narula
Philosophical Transactions of the Royal Society B: Biological Sciences 365 …, 2010
412010
Slowdown of growth controls cellular differentiation
J Narula, A Kuchina, F Zhang, M Fujita, GM Süel, OA Igoshin
Molecular systems biology 12 (5), 871, 2016
392016
A novel GUCY2C-CD3 T-cell engaging bispecific construct (PF-07062119) for the treatment of gastrointestinal cancers
D Mathur, AR Root, B Bugaj-Gaweda, S Bisulco, X Tan, W Fang, ...
Clinical Cancer Research 26 (9), 2188-2202, 2020
372020
One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics
W Chen, F Yang, C Wang, J Narula, E Pascua, I Ni, S Ding, X Deng, ...
MAbs 13 (1), 1871171, 2021
342021
Functional requirements of cellular differentiation: lessons from Bacillus subtilis
J Narula, M Fujita, OA Igoshin
Current opinion in microbiology 34, 38-46, 2016
332016
PF-07059013: a noncovalent modulator of hemoglobin for treatment of sickle cell disease
A Gopalsamy, AE Aulabaugh, A Barakat, KC Beaumont, S Cabral, ...
Journal of Medicinal Chemistry 64 (1), 326-342, 2020
312020
Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence
J Narula, CJ Williams, A Tiwari, J Marks-Bluth, JE Pimanda, OA Igoshin
Developmental biology 379 (2), 258-269, 2013
272013
A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins
AM Kierzek, TP Hickling, I Figueroa, JC Kalvass, M Nijsen, K Mohan, ...
CPT: Pharmacometrics & Systems Pharmacology 8 (11), 773, 2019
222019
Importance of feedback and feedforward loops to adaptive immune response modeling
A Rahman, A Tiwari, J Narula, T Hickling
CPT: Pharmacometrics & Systems Pharmacology 7 (10), 621-628, 2018
162018
Thermodynamic models of combinatorial gene regulation by distant enhancers
J Narula, OA Igoshin
IET Systems Biology 4 (6), 393-408, 2010
162010
Role of autoregulation and relative synthesis of operon partners in alternative sigma factor networks
J Narula, A Tiwari, OA Igoshin
PLoS Computational Biology 12 (12), e1005267, 2016
142016
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors
AR Root, G Guntas, M Katragadda, JR Apgar, J Narula, CS Chang, ...
MAbs 13 (1), 1850395, 2021
122021
Quantitative systems pharmacology modeling provides insight into inter‐mouse variability of anti‐CTLA4 response
W Qiao, L Lin, C Young, J Narula, F Hua, A Matteson, A Hooper, ...
CPT: Pharmacometrics & Systems Pharmacology 11 (7), 880-893, 2022
72022
Maximum entropy production allows a simple representation of heterogeneity in semiarid ecosystems, Philos
SJ Schymanski, A Kleidon, M Stieglitz, J Narula
TR Soc. B, 365, 1545, 1449–1455, 2010
72010
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Artículos 1–20