| Identification of the formycin A biosynthetic gene cluster from Streptomyces kaniharaensis illustrates the interplay between biological pyrazolopyrimidine formation and de novo … SA Wang, Y Ko, J Zeng, Y Geng, D Ren, Y Ogasawara, S Irani, Y Zhang, ... Journal of the American Chemical Society 141 (15), 6127-6131, 2019 | 42 | 2019 |
| Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity WC Lu, A Saha, W Yan, K Garrison, C Lamb, R Pandey, S Irani, A Lodi, ... Proceedings of the National Academy of Sciences 117 (23), 13000-13011, 2020 | 37 | 2020 |
| Snapshots of CS cleavage in Egt2 reveals substrate specificity and reaction mechanism S Irani, N Naowarojna, Y Tang, KR Kathuria, S Wang, A Dhembi, N Lee, ... Cell chemical biology 25 (5), 519-529. e4, 2018 | 35 | 2018 |
| Mapping the Phosphorylation Pattern of Drosophila melanogaster RNA Polymerase II Carboxyl-Terminal Domain Using Ultraviolet Photodissociation Mass … JE Mayfield, MR Robinson, VC Cotham, S Irani, WL Matthews, A Ram, ... ACS chemical biology 12 (1), 153-162, 2017 | 30 | 2017 |
| Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb JE Mayfield, S Irani, EE Escobar, Z Zhang, NT Burkholder, MR Robinson, ... Elife 8, e48725, 2019 | 28 | 2019 |
| Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST) NT Burkholder, JE Mayfield, X Yu, S Irani, DK Arce, F Jiang, WL Matthews, ... Journal of Biological Chemistry 293 (43), 16851-16861, 2018 | 22 | 2018 |
| Simplicity is the ultimate sophistication—crosstalk of post-translational modifications on the rna polymerase ii MKV Ramani, W Yang, S Irani, Y Zhang Journal of molecular biology 433 (14), 166912, 2021 | 19 | 2021 |
| Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase S Irani, SD Yogesha, J Mayfield, M Zhang, Y Zhang, WL Matthews, G Nie, ... Science signaling 9 (417), ra24-ra24, 2016 | 19 | 2016 |
| Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its … N Naowarojna, S Irani, W Hu, R Cheng, L Zhang, X Li, J Chen, YJ Zhang, ... ACS catalysis 9 (8), 6955-6961, 2019 | 18 | 2019 |
| Intramolecular cleavage of the hASRGL1 homodimer occurs in two stages W Li, S Irani, A Crutchfield, K Hodge, W Matthews, P Patel, YJ Zhang, ... Biochemistry 55 (6), 960-969, 2016 | 17 | 2016 |
| The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration R Zhou, Q Wu, M Wang, S Irani, X Li, Q Zhang, F Meng, S Liu, F Zhang, ... PLoS Biology 19 (2), e3001122, 2021 | 14 | 2021 |
| Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription S Irani, SN Sipe, W Yang, NT Burkholder, B Lin, K Sim, WL Matthews, ... Journal of Biological Chemistry 294 (21), 8592-8605, 2019 | 10 | 2019 |
| Structural motifs for CTD kinase specificity on RNA polymerase II during eukaryotic transcription MKV Ramani, EE Escobar, S Irani, JE Mayfield, RY Moreno, ... ACS chemical biology 15 (8), 2259-2272, 2020 | 9 | 2020 |
| Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct Tyr1 phosphorylation NT Burkholder, SN Sipe, EE Escobar, M Venkatramani, S Irani, W Yang, ... ACS chemical biology 14 (10), 2264-2275, 2019 | 7 | 2019 |
| Targeted covalent inhibition of small CTD phosphatase 1 to promote the degradation of the REST transcription factor in human cells B Medellin, W Yang, S Konduri, J Dong, S Irani, H Wu, WL Matthews, ... Journal of medicinal chemistry 65 (1), 507-519, 2021 | 4 | 2021 |
| Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity NT Burkholder, B Medellin, S Irani, W Matthews, SA Showalter, YJ Zhang Methods in enzymology 607, 269-297, 2018 | 4 | 2018 |
| Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation S Irani, W Tan, Q Li, W Toy, C Jones, M Gadiya, A Marra, ... The Journal of Clinical Investigation 134 (1), 2024 | 3 | 2024 |
| SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia SA Polyanskaya, RY Moreno, B Lu, R Feng, Y Yao, S Irani, O Klingbeil, ... Cell reports 38 (2), 2022 | 2 | 2022 |
| Electrophoretic Mobility Shift Assay of in vitro Phosphorylated RNA Polymerase II Carboxyl-terminal Domain Substrates JE Mayfield, S Irani, Y Zhang Bio-protocol 10 (12), e3648-e3648, 2020 | 2 | 2020 |
| Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb JE Mayfield, S Irani, EE Escobar, Z Zhang, NT Burkholder, MR Robinson, ... bioRxiv, 652214, 2019 | 2 | 2019 |
