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Colin Hockings
Colin Hockings
Department of Chemical Engineering & Biotechnology, University of Cambridge
Correu electrònic verificat a cam.ac.uk
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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ...
Cell 152 (3), 519-531, 2013
6322013
Bax dimerizes via a symmetric BH3: groove interface during apoptosis
G Dewson, S Ma, P Frederick, C Hockings, I Tan, T Kratina, RM Kluck
Cell Death & Differentiation 19 (4), 661-670, 2012
2062012
VDAC2 enables BAX to mediate apoptosis and limit tumor development
HS Chin, MX Li, IKL Tan, RL Ninnis, B Reljic, K Scicluna, LF Dagley, ...
Nature communications 9 (1), 4976, 2018
1262018
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
C Hockings, K Anwari, RL Ninnis, J Brouwer, M O'Hely, M Evangelista, ...
Cell death & disease 6 (4), e1735-e1735, 2015
952015
Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis
S Ma, C Hockings, K Anwari, T Kratina, S Fennell, M Lazarou, MT Ryan, ...
Journal of Biological Chemistry 288 (36), 26027-26038, 2013
842013
A highly porous metal-organic framework system to deliver payloads for gene knockdown
MH Teplensky, M Fantham, C Poudel, C Hockings, M Lu, A Guna, ...
Chem 5 (11), 2926-2941, 2019
772019
Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins
C Hockings, AE Alsop, SC Fennell, EF Lee, WD Fairlie, G Dewson, ...
Cell Death & Differentiation 25 (4), 721-734, 2018
542018
Physiological restraint of Bak by Bcl-xL is essential for cell survival
EF Lee, S Grabow, S Chappaz, G Dewson, C Hockings, RM Kluck, ...
Genes & development 30 (10), 1240-1250, 2016
542016
BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove
MX Li, IKL Tan, SB Ma, C Hockings, T Kratina, MA Dengler, AE Alsop, ...
Proceedings of the National Academy of Sciences 114 (29), 7629-7634, 2017
382017
Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells
CL Novo, EV Wong, C Hockings, C Poudel, E Sheekey, M Wiese, ...
Nature communications 13 (1), 3525, 2022
322022
Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
J Lautenschläger, S Wagner-Valladolid, AD Stephens, ...
Journal of Biological Chemistry 295 (30), 10138-10152, 2020
292020
A waveguide imaging platform for live‐cell TIRF imaging of neurons over large fields of view
IS Opstad, F Ströhl, M Fantham, C Hockings, O Vanderpoorten, ...
Journal of Biophotonics 13 (6), e201960222, 2020
162020
Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport
T Konno, P Parutto, DMD Bailey, V Davì, C Crapart, MA Awadelkareem, ...
bioRxiv, 2021.05. 10.441946, 2021
122021
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
EM Linossi, K Li, G Veggiani, C Tan, F Dehkhoda, C Hockings, DJ Calleja, ...
Nature Communications 12 (1), 7032, 2021
82021
Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion
L Chen-Wichmann, M Shvartsman, C Preiss, C Hockings, R Windisch, ...
Oncogene 38 (2), 261-272, 2019
62019
Illuminating chromatin compaction in live cells and fixed tissues using SiR-DNA fluorescence lifetime
C Hockings, C Poudel, KA Feeney, CL Novo, MS Hamouda, I Mela, ...
BioRxiv, 2020.05. 02.073536, 2020
52020
Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation
C Hockings, S Iyer, RT Uren, RM Kluck
Cell Death & Differentiation 26 (5), 794-795, 2019
22019
BAX requires VDAC2 to mediate apoptosis and to limit tumor development
HS Chin, MF van Delft, RL Ninnis, MX Li, IKL Tan, B Reljic, K Scicluna, ...
BioRxiv, 266668, 2018
12018
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands (vol 4, 7951, 2023)
EM Linossi, K Li, G Veggiani, C Tan, F Dehkhoda, C Hockings, DJ Calleja, ...
NATURE COMMUNICATIONS 14 (1), 2023
2023
Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
EM Linossi, K Li, G Veggiani, C Tan, F Dehkhoda, C Hockings, DJ Calleja, ...
nature communications 14, 2023
2023
En aquests moments el sistema no pot dur a terme l'operació. Torneu-ho a provar més tard.
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