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Macarena Martínez-Bailén
Macarena Martínez-Bailén
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Year
Tuning of β-glucosidase and α-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules
M Martinez-Bailen, AT Carmona, E Moreno-Clavijo, I Robina, D Ide, ...
European Journal of Medicinal Chemistry 138, 532-542, 2017
282017
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry …
M Martinez-Bailen, AT Carmona, F Cardona, C Matassini, A Goti, M Kubo, ...
European Journal of Medicinal Chemistry 192, 112173, 2020
192020
Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition
M Martinez-Bailen, AT Carmona, AC Patterson-Orazem, RL Lieberman, ...
Bioorganic chemistry 86, 652-664, 2019
182019
Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning
F Clemente, C Matassini, C Faggi, S Giachetti, C Cresti, A Morrone, ...
Bioorganic Chemistry 98, 103740, 2020
162020
Antimicrobial activity of phenolics isolated from the pruning wood residue of European plum (Prunus domestica L.)
J Ortega-Vidal, A Cobo, E Ortega-Morente, A Gálvez, M Martínez-Bailén, ...
Industrial Crops and Products 176, 114296, 2022
152022
GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders
M Martínez-Bailén, F Clemente, C Matassini, F Cardona
Pharmaceuticals 15 (7), 823, 2022
142022
Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars
M Martinez-Bailen, E Jimenez-Ortega, AT Carmona, I Robina, ...
Bioorganic Chemistry 89, 103026, 2019
142019
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono-and divalent pyrrolidine iminosugars
V Pingitore, M Martínez-Bailén, AT Carmona, Z Mészáros, N Kulik, ...
Bioorganic Chemistry 120, 105650, 2022
122022
Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)
F Clemente, C Matassini, S Giachetti, A Goti, A Morrone, ...
The Journal of Organic Chemistry 86 (18), 12745-12761, 2021
122021
Multivalent glycosystems for human lectins
M Martínez-Bailén, J Rojo, J Ramos-Soriano
Chemical Society Reviews, 2023
112023
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
J Franco, F Piacente, M Walter, S Fratta, M Ghanem, A Benzi, I Caffa, ...
Pharmaceuticals 15 (7), 855, 2022
102022
Exploring Multi‐Subsite Binding Pockets in Proteins: DEEP‐STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
S Monaco, S Walpole, H Doukani, R Nepravishta, M Martínez‐Bailén, ...
Chemistry–A European Journal 26 (44), 10024-10034, 2020
72020
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease
M Velueta-Viveros, M Martínez-Bailén, A Puerta, LL Romero-Hernández, ...
Bioorganic Chemistry, 105983, 2022
52022
Regioselectivity of the 1, 3-dipolar cycloaddition of organic azides to 7-heteronorbornadienes. Synthesis of β-substituted furans/pyrroles
E Gil de Montes, M Martı́nez-Bailén, AT Carmona, I Robina, ...
The Journal of Organic Chemistry 85 (14), 8923-8932, 2020
52020
Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors
MG Davighi, F Clemente, C Matassini, A Morrone, A Goti, ...
Molecules 25 (19), 4526, 2020
52020
Synthesis of a new β-galactosidase inhibitor displaying pharmacological chaperone properties for GM1 gangliosidosis
F Clemente, M Martínez-Bailén, C Matassini, A Morrone, S Falliano, ...
Molecules 27 (13), 4008, 2022
42022
Preparation of water-soluble glycopolymers derived from five-membered iminosugars
M Martinez-Bailen, E Galbis, AT Carmona, MV de-Paz, I Robina
European Polymer Journal 119, 213-221, 2019
32019
Stereoselective Synthesis of Heavily Hydroxylated Azepane Iminosugars via Osmium-Catalyzed Tethered Aminohydroxylation
M Martínez-Bailén, C Matassini, F Clemente, C Faggi, A Goti, F Cardona
Organic Letters 25 (31), 5833-5837, 2023
2023
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